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Characteristics of 24,516 Patients Diagnosed with COVID-19 Illness in a National Clinical Research Network: Results from PCORnet
Jason P Block; Keith A. Marsolo; Kshema Nagavedu; L Charles Bailey; Henry Cruz; Christopher B. Forrest; Kevin Haynes; Adrian F. Hernandez; Rainu Kaushal; Abel Kho; Kathleen M. McTigue; Vinit P. Nair; Richard Platt; Jon Puro; Russell L. Rothman; Elizabeth Shenkman; Lemuel Russell Waitman; Mark G. Weiner; Neely Williams; Thomas W. Carton.
Afiliação
  • Jason P Block; Harvard Pilgrim Health Care Institute/Harvard Medical School
  • Keith A. Marsolo; Duke University
  • Kshema Nagavedu; Harvard Pilgrim Health Care Institute
  • L Charles Bailey; Childrens Hospital of Philadelphia
  • Henry Cruz; PCORnet
  • Christopher B. Forrest; Childrens Hospital of Philadelphia
  • Kevin Haynes; HealthCore
  • Adrian F. Hernandez; Duke Clinical Research Institute
  • Rainu Kaushal; Weill Cornell Medicine
  • Abel Kho; Northwestern University
  • Kathleen M. McTigue; University of Pittsburgh
  • Vinit P. Nair; PRACnet
  • Richard Platt; Harvard Pilgrim Health Care Institute/Harvard Medical School
  • Jon Puro; OCHIN, Inc
  • Russell L. Rothman; Vanderbilt University Medical Center
  • Elizabeth Shenkman; College of Medicine, University of Florida
  • Lemuel Russell Waitman; University of Kansas Medical Center
  • Mark G. Weiner; Weill Cornell Medicine
  • Neely Williams; Community Partners Network Inc
  • Thomas W. Carton; Louisiana Public Health Institute
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20163733
ABSTRACT
BackgroundNational data from diverse institutions across the United States are critical for guiding policymakers as well as clinical and public health leaders. This study characterized a large national cohort of patients diagnosed with COVID-19 in the U.S., compared to patients diagnosed with viral pneumonia and influenza. Methods and FindingsWe captured cross-sectional information from 36 large healthcare systems in 29 U.S. states, participating in PCORnet(R), the National Patient-Centered Clinical Research Network. Patients included were those diagnosed with COVID-19, viral pneumonia and influenza in any care setting, starting from January 1, 2020. Using distributed queries executed at each participating institution, we acquired information for patients on care setting (any, ambulatory, inpatient or emergency department, mechanical ventilator), age, sex, race, state, comorbidities (assessed with diagnostic codes), and medications used for treatment of COVID-19 (hydroxychloroquine with or without azithromycin; corticosteroids, anti-interleukin-6 agents). During this time period, 24,516 patients were diagnosed with COVID-19, with 42% in an emergency department or inpatient hospital setting; 79,639 were diagnosed with viral pneumonia (53% inpatient/ED) and 163,984 with influenza (41% inpatient/ED). Among COVID-19 patients, 68% were 20 to <65 years of age, with more of the hospitalized/ED patients in older age ranges (23% 65+ years vs. 12% for COVID-19 patients in the ambulatory setting). Patients with viral pneumonia were of a similar age, and patients with influenza were much younger. Comorbidities were common, especially for patients with COVID-19 and viral pneumonia, with hypertension (32% for COVID-19 and 46% for viral pneumonia), arrhythmias (20% and 35%), and pulmonary disease (19% and 40%) the most common. Hydroxychloroquine was used in treatment for 33% and tocilizumab for 11% of COVID-19 patients on mechanical ventilators (25% received azithromycin as well). Conclusion and RelevancePCORnet leverages existing data to capture information on one of the largest U.S. cohorts to date of patients diagnosed with COVID-19 compared to patients diagnosed with viral pneumonia and influenza.
Licença
cc_by_nc_nd
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Cohort_studies / Observational_studies / Prognostic_studies / Rct Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Cohort_studies / Observational_studies / Prognostic_studies / Rct Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint