Molecular regulatory pathways associated with posterior capsular opacification / 眼科新进展

ABSTRACT

Cataract surgery is one of the most common and mature eye surgeries in the world,and the procedures include the removal of turbid lens and intraocular lens (IOL) implantation,which can better restore the patient' s vision.Posterior capsular opacification (PCO),also known as secondary cataract,is one of the most coramon complications after cataract surgery,seriously affecting the surgical efficacy.Two to five years after cataract surgery,PCO-induced loss of vision accounted for 20％-40％ of patients.PCO is a fibrotic disease,and its mechanism has become an important medical topic.It has been demonstrated that the residual lens epithelial cells (LECs) in the equatorial and anterior capsule region after surgery have become fibroblasts and myofibroblasts via proliferation,migration and epithelial-mesenchymal transition (EMT) accompanied by extracellular matrix (ECM) synthesis,eventually leading to the occurrence of PCO.A series of growth factors and signaling pathways participate and play a key role in the initiation and development of PCO.In this review,recent advances in molecular regulation pathways associated with PCO will be summarized,and the possible methods interfering with PCO will be explored.