Objective:
To investigate differences in
serum uric acid levels between
elderly patients with
prostate cancer and
patients with
benign prostatic hyperplasia(BPH).
Methods:
A total of 300
prostate cancer patients admitted to the
urology department of our
hospital between Feb.2010 and Jun.2019 were retrospectively analyzed.During the same period, 240 BPH
patients and 400
elderly men with normal
prostate size were enrolled as the
control group.
Serum uric acid and
prostate-specific antigen(PSA)levels,
C-reactive protein(CRP),
neutrophil count and
lymphocyte count were determined.
Serum uric acid concentrations were monitored in
prostate cancer patients with different clinicopathological characteristics.
Results:
CRP and Neu/Lym levels were higher in the
prostate cancer group than in the BPH and
control groups( P<0.05). The
serum uric acid level was (327.0±58.3)μmol/L in the
prostate cancer group, lower than in the BPH group(375.2±68.4)μmol/L and the
control group(377.8±73.2)μmol/L( F=55.69, P<0.001). Multivariable
Logistic regression analysis indicated that
serum uric acid was a
protective factor for
prostate cancer( OR=0.593, 95% CI 0.542-0.718, P=0.004). There were significant differences in
serum uric acid levels between
prostate cancer patients with different ages and pathological grades( t=-4.63, F=12.73, P<0.001). However,
serum uric acid levels were not significantly correlated with clinical staging or
lymph node metastasis( F=-2.72 and 0.77, P=0.068 and 0.460).
Conclusions:
Compared with BPH
patients and healthy
males,
serum uric acid levels are reduced and inflammatory markers are increased in
prostate cancer patients, indicating that
serum uric acid may be a
risk factor for the occurrence and progression of
prostate cancer in the
elderly.