Asunto(s)
Demencia , Trastorno Depresivo Mayor , Servicios de Salud Mental , Anciano , Demencia/terapia , Trastorno Depresivo Mayor/terapia , Femenino , Francia , HumanosAsunto(s)
Violación , Adulto , Coito , Testimonio de Experto , Femenino , Humanos , Trastornos del Humor , Personalidad , Violación/legislación & jurisprudencia , Conducta Sexual , ViolenciaRESUMEN
The action of bromazepam was assessed in 30 patients whose dominant symptom was anxiety in clinical presentations of neurosis, depression, drug-addiction or alcoholism, senile dementia or oligophrenia. The doses administered ranged from 6 to 12 mg/day and in some cases from 18 to 36 mg/day. Distinct improvement was noted in 20 patients, the effects of the drug on anxiety being manifested within 2 to 3 days. The somatic symptoms of anxiety and sleep disturbances were also improved. However, depressive and psychotic symptoms remained unchanged and it was necessary to combine diazepam with other drugs. Side-effects consisted of daytime somnolence in 2 cases and feeling of dizziness in 3 cases.
Asunto(s)
Ansiolíticos/uso terapéutico , Trastornos de Ansiedad/tratamiento farmacológico , Bromazepam/uso terapéutico , Adulto , Anciano , Trastornos de Ansiedad/psicología , Bromazepam/efectos adversos , Evaluación de Medicamentos , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
A total of 186 patients who met the DSM-III criteria for schizophrenia were admitted to a double-blind randomized multicentre trial in which the efficacy and safety of remoxipride at two dose levels was compared with those of haloperidol. Over a period of six weeks the patients received remoxipride 100-300 mg/day (n = 60), remoxipride 200-600 mg/day (n = 61), or haloperidol 10-30 mg/day (n = 64). There was no significant difference between the three treated groups with regard to the Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression (CGI) scores obtained. Remoxipride, at both dosage ranges used, thus had comparable therapeutic efficacy to that of haloperidol. In contrast, extrapyramidal symptoms occurred significantly more frequently in the group treated with haloperidol. Laboratory tests and cardiovascular investigations showed no specific drug effect in any of the treated patients. Remoxipride is thus effective in acute treatment of schizophrenia at both dosage levels and has an advantage over haloperidol in neurological acceptability.