[Our attitude in esophageal and gastric post-caustic lesions]. / Atitudinea noastra în leziunile esofagiene si/sau gastrice post caustice.

The authors present the experience of the surgery section in patients treatment with oesophagian or gastric lesions after caustic substances ingestion. From a group of 70 patients who were treated in a conservative way (with medicines and dilatations) 60 of them returned to the surgery for nourishment gastrostomy. In two cases, the oesophagian and gastric lesions was established preoperations trough radiologic examination and in thirteen cases the lesions were found intraoperation. The adopted attitude is exemplified presenting a case. Under a general anaesthesia is done a limited resection (about 3 cm) with termino-terminal anastomosis of the stenosed antral area keeping the vascular arches of the little and big gastric curvature. A minimal a la Gavriliu gastrostomy is mounted on the vertical area of the little curvature. Through the gastrostomy (Petzzer) probe is put a tube of perfusor to the first jejununal ansa. In the first 48 hours the Petzeer is used for the gastric drainage in the perfusor probe for feeding. After 48 hours the jejununal probe is taken away and the gastrostomic feeding begins. After six mouths from the caustic ingestion 25 patients come back again for oesophagian reconstruction. For 24 patients the Gavriliu I, II proceeding is applied and for a case it is used the small intestine ansa. They lost 3 patients (2 with gastric tube and 1 with intestinal ansa). The evolution in 24 years time was very good.

[Simon's posterior vertical lombotomy in the conservative treatment of upper lumbar renal and ureteral lithiasis]. / Lombotomia verticala posterioara Simon in tratamentul conservator al litiazei renale si a ureterului lombar superior.

The authors present their experience accumulated in the treatment of 107 cases in which they have applied posterior vertical lombotomies as a conservative method of renal lithiasis and of the upper lumbal urether, and they re-actualize ore of the less used approaches. From the very beginning it is evident that vertical posterior lombotomy can be used as a narrow approach and, at the same time it can be created or it may be widended, just as a classical lombotomy. A secure technique, that of intra-sinusal pyelotomy, will determine, together with the type of the lithiasis, a choice of posterior lombotomy, with a sufficiently wide access pathway, which only in exceptional conditions will necessitate a cranial or caudal extension. This type of lombotomy, without fatalities, intra-surgical hemorrhagic accidents, severe complications after surgery, and especially, lacking the risk of lithiasis relapse, allows for an in situ kidney surgery and will protect the tissues to the utmost.

[Fluorescent antibody method in the study of an antiviral agent: 5-sulfamido--isatin-thiosemicarbazone]. / Metoda anticorpilor fluorescenti în studiul unei substante antivirale: 5-sulfamide-isatin-tiosemicarbazona

Direct immunofluorescence supplied evidence of the antiviral action of a new synthetic derivative (5-sulfamido-ITSC) against vaccina virus in HeLa cell cultures. The antiviral potential of the new derivative is expressed by a 10-18 delay in the appearance of the viral antigen and by the quantitative reduction of synthesis. Administered in a single dose of 40 uM/ml, after infection of the HeLa cells, 5-sulfamido-ITSC does not arrest the infection and bring about elimination of the virus from the cell, in the course of a single viral multiplication cycle. Direct immunofluorescence is a rapid, specific method for detection of the in vitro antiviral action of synthetic derivatives.

[Relations between the principal classes of serum immunoglobulins and serodiagnostic tests in viroses. I. Influenza infection]. / Relatia dintre principalele clase de imunoglobuline serice si reactiile de serodiagnostic în viroze. I. Infectia gripala

The relationship between the main serum immunoglobulin classes (IgM, IgG) and the positive diagnostic serologic tests (hemagglutination-inhibition and complement fixation) followed up in 30 paired serum samples from patients in the course of a primary influenza infection with B virus strain, before and after treatment with 2-ME, showed actual participation of the IgM molecules sensitive to 2-ME in the CF test. HI with the serum fractions of patients and convalescents of influenza B, in the presence of virus strains A and B, that had circulated earlier in the area, showed anamnestic responses by the presence of IgG and IgA antibodies in the patients' sera; HI and CF with the same serum fractions in the presence of virus B/Iasi/74 of the epidemic, showed the presence of IgM, IgG and IgA in the convalescent sera, as also demonstrated by immunoprecipitation in agar gel with specific IgM, and IgA antisera and by treatment with 2-ME. Separation of these sera on a Sephadex G-200 column revealed filtration of IgM antibodies at the same peak as the IgG and IgA antibodies, possessing a closely resembling molecular weight (7S) and probably being IgM subunits with an immunologic behaviour similar to that of the intact molecule sensitive to 2-ME.

Atypic adenomatous hyperplasiae of the endometrium. Cytologic and histopathologic confrontations.

By cytologic and histopathologic confrontations performed in uterine curettage products, 34 atypic adenomatous hyperplasiae were comparatively analysed with 38 malignant proliferations of the endometrium. The confrontation was made with the aim of knowing the diagnosis significance of some atypic adenomatous hyperplasiae lesions, finally correlated with the diagnosis established on histerectomy pieces. The significance of anomalies and/or atypies generated by disorders occurred in the cytodifferentiation of glandular cells and of those of the covering epithelium of the endometrium are discussed as well as the value of methods for the early diagnosis of the malignant process at the level of endometrium.

Comparative behaviour of antithrombin III antigen and antithrombin III activity in cardiovascular patients.

Antithrombin III-functional (AT III F) and immunoprotein (AT III I) assessed by two comparative methods in various cardiovascular conditions, showed significant differences between the two parameters, namely: a simultaneous decrease of both AT III F and AT III I during acute embolic episodes of only AT III F in transient ischemic attacks (with normal level of AT III I) and increase of AT III I (with apparently normal AT III F) in patient with mitral valve prosthesis. It is considered that in condition of "hypercoagulability" various patterns of AT III F/AT III I ratio can be obtained: decompensated, compensated and hypercompensated consumption.

[A study on periodontal implications of the therapy for dento-maxillary anomalies]. / Studiu privind implicatiile parodontale ale terapiei anomaliilor dentomaxilare.

Dento-maxillary anomalies are the results of a deviation of growth processes, or of the development of the dento-maxillary apparatus. From the viewpoint of their frequencies the dento-maxillary anomalies hold the third place in the list of stomatological affections. The great variety of clinical manifestations of dento-maxillary anomalies has determined definition of therapeutical attitudes, in the frame of which therapy with orthodontal devices has an important place. This type of therapy exerts its effects also by implicating the parodontium, and this by at least two different mechanisms:-the induction of changes in the structures of the dento-maxillary apparatus by a direct parodontal mechanisms; as an element in the overall regulation of the growth of the dento-maxillary apparatus. The treatment with orthodontial devices should be conceived in such a way that it will protect the parodontium from the deleterious effects of these devices. The data presented further were obtained from 2 groups of patients and concern the improvement of the efficiency of treatments with orthodontal devices, and the protection of the parodontium during treatment. The first group was investigated in 1988, and criteria for the selection of participants in the second group were established. In the first group a total of 109 subjects were included, aged between 5 and 20 years, in whom stomatologic procedures were started in January 1988. These subjects were followed until the month of November of the same year. The most frequently encountered anomaly was maxillary compression (endalvellia) in 70 subjects. With regard to the condition of the marginal parodontium clinical exploration showed that 57 subjects had not underwent changes.(ABSTRACT TRUNCATED AT 250 WORDS)

[Contribution of immediate orthopedic-orthodontic treatment in maxillo-palatine-labial clefts]. / Aportul tratamentului asociate ortopedico-ortodontic în despicaturile labio-maxilo-palatine.

Labio-maxillo-palatine clefts are pathological conditions accompanied by severe handicaps, congenital malformations of particular interest for medical assistance because of several reasons, including the following: they are the most frequent congenital malformations of the bucco-maxillo-facil region: in certain cases there are other teratologic conditions in other parts of the organism that are associated to these clefts; there are no disturbances from the intellectual viewpoint; there are efficient possibilities for therapy as a result of a multidisciplinary approach, and the progress achieved in each of the fields involved may contribute to continuous improvement of the therapeutical prognosis; because of the therapeutical problems that these pathological conditions may raise, and because of the long duration of the treatment, the pathology involved in labio-maxillo-palatine clefts has a special social character which renders necessary the support of extra-medical factors (special schooling, special conditions for work, etc.). All these aspects explain the world-wide interest for this type of pathology, as it is also reflected in the large number of scientific manifestations dedicated exclusively, or in association to this problem, aimed at achieving a permanent therapeutic progress in this field. In the period between 1986 and 1987 the authors have selected 60 patients out of those hospitalized for this defect in the Clinic. The patients were aged between 2 and 43 years. Orthodontal therapy is the type of therapy which takes the longest time in these patients. This is achieved by the successive application of orthodontal devices, which necessitate a long-term therapeutic strategy. In the course of this therapy a permanent cooperation is necessary between the specialist in orthodontics and the maxillofacial surgeon. A common approach is beneficial for both specialties. The number of specialists in orthodontics involved in the orthodontal therapy of labio-maxillo-palatine clefts is alarmingly low, and thus there is no possibility to evolve a special program for their further special education. Another difficulty is the fact that patients from all over the country demand the services of the same specialist, and a series of aspects evolve from this situation, as follows: the patients (usually accompanied by one of the parents) have to perform long trips, which are also expensive; when incidents occur, in relation with the use of a orthodontal device these patients cannot require immediately the assistance of specialized services, and, as a result, the number of recidives is alarmingly high.(ABSTRACT TRUNCATED AT 400 WORDS)

[The clinical and technological particularities of using Gaudent "S" and Gaudor alloys in the conjoint treatment of extensive edentation]. / Studiul particularitatilor clinice si tehnologice ale utilizarii aliajelor Gaudent S si Gaudor în terapia conjuncta a edentatiilor întinse.

The present paper forms part of a longitudinal study on prostheses restaurations with Romanian non-noble alloys for establishing the clinical, technological and biological implications of their utilization in mass assistance. The large contact surface with biological structures and the buccal medium of total conjoint restaurations permitted chacking of previous data regarding the biological behaviour of these alloys. In the group of 58 patients with total bridges followed up for 2 to 5 years there were no adverse reactions in which the alloy used could be incriminated. The iatrogenic aspects observed consequent to the application of prostheses were common to the use of any other metal alloy. The surface colour changes in a reduced number of cases depended upon the technologic preparation of the alloys and particularly upon the patient's limited ability to keep the plate under bacterial control. The study demonstrated that casting of a total Gaudent S bridge under present conditions does not give correct adaptation of the cervical limits which means more accurate compliance with the technology and homologation of the specific of this alloy.