[Condition of the tissue oxygen regime of patients with essential hypertension with different types of hemodynamics]. / Sostoianie kislorodnogo rezhima tkanei u bol'nykh gipertonicheskoi bolezn'iu s razlichnymi tipami gemodinamiki.

Systemic and regional hemodynamic parameters were investigated using echocardiography, venous-occlusion plethysomography, and tissue oxygen regimen was studied polargraphically, in 51 patients with essential hypertension. Tissue oxygen supply becomes increasingly inadequate as the disease progresses, as reflected in limited oxygen delivery to tissues, its reduced utilization, and smaller reserve capacities of oxygen transport at the microcirculatory level. In patients with hyperkinetic circulation, increased blood stroke volume was combined with a significant increase in baseline tissue oxygen tension and the capillary-to-tissue oxygen diffusion rate, while changes in the resistive vascular element were basically functional. Changes in regional hemodynamics and tissue oxygen supply were particularly severe in patients with hypokinetic circulation.

[Evaluation of the adequacy of hypotensive therapy based on the status of the tissue oxygen system and serum lactate dehydrogenase and cytochrome oxidase activities in patients with hypertension]. / Otsenka adekvatnosti gipotenzivnoi terapii po sostoianiiu kislorodnogo rezhima tkanei i aktivnosti laktatdegidrogenazy i tsitokhromoksidazy v syvorotke krovi u bol'nykh gipertonicheskoi bolezn'iu.

Parameters of tissue oxygen regime measured by polarography and serum lactate dehydrogenase (LDG) and cytochrome oxidase (CO), oxidation-reduction enzymes, were studied in 23 patients with stable hypertension of various hemodynamic types. The nature of the tissue oxygen regime and changes observed in the isoenzymic spectra of LDG and CO were found to be associated with BP levels, hemodynamic types and BP reduction degree. The time course of these values may be useful in assessing whether the antihypertensive therapy is appropriate and in determining an optimal level of BP decrease.

[Changes in regional hemodynamics and tissue oxygenation in heart failure patients as affected by nifedipine (corinfar)]. / Izmenenie regionarnoi gemodinamiki i oksigenatsii tkani u bol'nykh s serdechnoi nedostatochnost'iu pod vliianiem nifedipina (korinfara).

Regional hemodynamics using plethysmography and tissue oxygen tension at the basal level and during corinfar administration were investigated in 38 patients with heart failure against a background of rheumatic heart valvular diseases, dilatation cardiomyopathy and coronary heart disease. A considerable decrease in regional vascular resistance (RVR) and improvement of tissue oxygenation were noted in persons with a raised basal RVR level. A value of an acute test with corinfar for administration of regular therapy was determined.

[Effect of ethacizine on indices of the oxygen regimen and blood perfusion of the skin in psoriasis patients]. / Vliianie étatsizina na pokazateli kislorodnogo rezhima i gemoperfuzii kozhi u bol'nykh psoriazom.

Oxygen regimen and hemoperfusion of affected and visually unchanged skin were studied in 35 patients with psoriasis universalis using methods of H and O polarography. Latent disorders of the microcirculatory system detected by functional tests were noted in visually unaffected skin zones. Sharp changes of oxygen regimen and hemoperfusion indices were noted in affected skin, especially during progression of disease. Course therapy with etatsizin at a daily dose of 150 mg resulted in a positive time course of a skin process in 91% of the patients; indices of microcirculation and tissue metabolism were significantly improved.

[The state of microcirculation, hemoperfusion and tissue oxygen consumption in patients with ischemic heart disease and angina pectoris]. / Sostoianie mikrotsirkuliatornogo rusla, gemoperfuzii i kislorodnogo rezhima tkani u bol'nykh ishemicheskoi bolezn'iu serdtsa so stenokardiei.

In patients with associated coronary heart disease and angina pectoris functional classes II-IV, microcirculatory disorders are linked with the gravity of the patients' clinico-functional status. Application of the functional tests (inhalation of 100% moistened oxygen, regional occlusion of the vessels of the limb under study) revealed the presence of latent deficiency of oxygen transport to the cellular substrate. In functional classes III and IV of disease, an appreciable reduction in the level of tissue hemoperfusion, of tissue oxygen supply, and an increase in the summary conjunctival index were recorded.

[Combined study of central hemodynamics and microcirculation in circulatory failure patients]. / Kompleksnoe izuchenie tsentral'noi gemodinamiki i mikrotsirkuliatsii u bol'nykh s nedostatochnost'iu krovoobrashcheniia.

The status of the central hemodynamics and microcirculatory bed was studied in 50 patients (aged 25-60 years) with coronary heart disease complicated by circulatory failure. The local tissue blood flow was investigated by the H-clearance method with an automatized apparatus made in the USSR, the capillaroscopic picture was observed with a TM-1 telecapillaroscope. The paper presents a discussion of the fact that with an increase in circulatory failure the changes in the central hemodymamics are accompanied by functional and morphologic disturbances in the microcirculatory bed.

[Complex study of the state of the microcirculatory bed at different stages of circulatory failure]. / Kompleksnoe izuchenie sostoianiia mikrotsirkuliatornogo rusla u bol'nykh s raznymi stadiiami nedostatochnosti krovoobrashcheniia.

The state of microcirculation was studied on 103 patients with the 1st-3rd degree of circulatory failure due to post-myocardial infarction cardiosclerosis and rheumatic valvular heart disease. The dynamics of the local blood flow in the skin of the left forearm (by the H-clearance method) as well as platelet aggregation ability were studied, conjunctival biomicroscopy and T-V capillaroscopy were performed. Already at early stages, patients with circulatory failure were observed to have changes in the microcirculation accompanied by a decrease in the volume velocity of the tissue (capillary) blood flow. As the circulatory failure developed, the aggravation of morphofunctional disturbances was accompanied by a significant retardation both of linear and volume velocity of the capillary blood flow as well as by an increase in aggregation properties of platelets.

[Disorders of oxygenation and skin capillary blood flow rate in psoriasis and correction of them with ethacizine]. / Narusheniia oksigenatsii i ob"emnoi skorosti kapilliarnogo krovotoka kozhi pri psoriaze i korrektsiia ikh étatsizinom.

Oxygen and hydrogen polarography has revealed functional changes of the oxygen regimen and hemoperfusion of both involved and apparently intact skin in patients with common psoriasis. These changes developed by stages and their intensity varied. Ethacizine therapy has been effective in 91% of the patients, improving the parameters of the skin capillary blood oxygenation and volumetric rate both during the stationary and progressive forms of the disease.