Asunto(s)
Albuminuria/etiología , Albuminuria/orina , Anemia de Células Falciformes/complicaciones , Peptidil-Dipeptidasa A/orina , Factores de Edad , Albuminuria/diagnóstico , Anemia de Células Falciformes/diagnóstico , Enzima Convertidora de Angiotensina 2 , Biomarcadores , Niño , Susceptibilidad a Enfermedades , Humanos , Sistema Renina-AngiotensinaAsunto(s)
Enfermedad de la Hemoglobina SC/complicaciones , Patrón de Herencia , Bazo/patología , Enfermedades del Bazo/prevención & control , Talasemia alfa/complicaciones , Niño , Estudios de Seguimiento , Humanos , Recién Nacido , Pronóstico , Estudios Retrospectivos , Factores de Riesgo , Enfermedades del Bazo/etiología , Enfermedades del Bazo/patologíaRESUMEN
Aim: The aim of this study was to compare novel kidney injury biomarkers in sickle cell anemia (SCA) children with and without albuminuria or glomerular hyperfiltration. Materials & methods: A total of 358 Brazilian children with SCA were studied. Fifteen kidney injury biomarkers in urine were measured. Albuminuria was defined as urine albumin/creatinine ratio >100 mg/g. Glomerular hyperfiltration was defined as estimated glomerular filtration rate ≥140 ml/min/1.73 m2. Results: After adjustment for age, sex and modifying therapies in use, EGF and collagen IV urinary levels were associated with albuminuria. Renin and clusterin levels were associated with hyperfiltration. Conclusion: Levels of novel kidney injury biomarkers were associated with albuminuria and hyperfiltration in Brazilian children with SCA, suggesting concomitant structural and functional abnormalities.