[Comparative analysis of quinolinic acid and L-kynurenine action on the electrically controlled membrane ion channels of mollusk neurons]. / Sravnitel'nyi analiz deistviia khinolinovoi kisloty i L-kinurenina na élektroupravliaemye ionnye kanaly membrany neironov molliuska.

Extrasynaptic effects of kynurenines (chynoline acid and L-kynurenin) on the membrane electrosensitive ionic channels were studied in experiments using isolated somata from the c. n. s. of mollusc Lymnaea stagnalis. The kynurenines either blocked or induced biphasic dose-dependent effect on amplitudes of the membrane ionic currents.

[A hypothesis of the possible mechanism of the action of analgesic agents at the neuronal level]. / Gipotez o vozmozhnom mekhanizme deistviia boleutoliaiushchikh sredstv na urovne neirona.

The opiate analgetic promedol and non-opiate analgetics analgin, clonidine, baclofen, tolibut, vasopressin and calcitonin given in adequate doses block the inward electrosensitive sodium transmembrane ionic current of neurons. Like some drugs which do not exhibit any analgetic effect, promedol, analgin, clonidine, vasopressin and calcitonin also block the electrosensitive delayed potassium current. It is assumed that the blocking of the sodium ionic current may be one of the potential analgetic mechanisms at the neuronal level.

[The extrasynaptic effect of the neuropeptides vasopressin, oxytocin and vasotocin on the electrically controlled ion channels of the membrane in mollusk neurons]. / Vnesinapticheskoe vliianie neiropeptidov vazopressina, oksitotsina i vazototsina na élektroupravliaemye ionnye kanaly membrany neironov molliuska.

Extrasynaptic effects of vasopressin, oxytocin, vasotocin on the membrane electrosensitive ionic channels were studied in model experiments using isolated somata from the CNS of mollusc Lymnaea stagnalis. The neuropeptide in concentrations of 1.10(-16)-1.10(-6) mol/l either blocked or induced biphasic dose-dependent effect on amplitudes of the membrane ionic currents.

[A new mechanism of action of vasopressin on the neuronal membrane]. / Novyi mekhanizm deistviia vazopressina na membranu neironov.

It is shown in this work that vasopressin at the concentrations of 1 x 10(-16) to 1 x 10(-6) mol/l decreased statistically significant the amplitude of the electrosensitive sodium and calcium ionic currents of the mollusc's Lymnaea stagnalis neuronal membrane. This peptide increased the amplitude of the fast potassium current at the concentration of 1 x 10(-16) and 1 x 10(-15) mol/l. It decreased the fast potassium current and did not change the slow potassium current at the concentrations more than 1 x 10(-9) mol/l.