Nicotinamide N-methyltransferase overexpression may be associated with poor prognosis in ovarian cancer.

Ovarian cancer is the fifth leading cause of cancer-related mortality in women. Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme and there is growing evidence to suggest that it plays an important role in cancer progression. This is the first study to examine the expression of NNMT in serous ovarian cystadenomas, serous borderline tumours, low grade serous carcinomas (LGSC) and high grade serous carcinomas (HGSC) and investigate the potential independent association of NNMT expression with survival. Tissue samples were analysed immunohistochemically for NNMT expression. The stromal NNMT score was significantly higher in HGSC compared to serous cystadenomas and serous borderline tumours (p < .001, p < .043, respectively). The mean stromal NNMT score of patients with HGSC was significantly higher than patients with LGSC (p = .043). Patients with low expression of NNMT had a significantly higher mean recurrence-free survival than patients with high expression (p = .036). NNMT may support tumour progression in ovarian cancer by promoting desmoplastic stromal tumour reaction. NNMT overexpression may be associated with poor prognosis and can be a therapeutic target in ovarian cancer.IMPACT STATEMENTWhat is already known on this subject? Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that is overexpressed in many malignancies. Its overexpression was shown to lead to histone hypomethylation, which in turn can decrease and increase the expression of tumour suppressor proteins and onco-proteins, respectively. NNMT was also shown to play a role in epithelial-to-mesenchymal transition, which is critical in tumour progression and the stromal tumour reaction. The stromal tumour reaction was recently targeted with promising therapeutic results in ovarian cancer.What do the results of this study add? The expression of NNMT in various ovarian neoplasms including serous cystadenomas, borderline tumours and serous carcinomas has not been studied and independently associated with poor survival, previously. This study suggests that NNMT is progressively overexpressed in the stroma of ovarian neoplasms from benign cysts to HGSCs. NNMT overexpression appears to be independently associated with poor survival in ovarian cancer.What are the implications of these findings for clinical practice and/or further research? The implications of these findings are that NNMT may play an important role in the stromal tumour reaction, and therefore its overexpression may contribute to poor survival. NNMT overexpression may be an important target of ovarian cancer therapy.

Is striae gravidarum a sign of spontaneous premature birth?

BACKGROUND: This study aimed to investigate the association of striae gravidarum (SG) and preterm delivery. MATERIAL AND METHODS: This prospective cross-sectional study was performed between November 2018 and February 2019. In addition to demographic variables, SG score of the abdomen, presence of striae on breasts, arms, hips, and thighs were recorded. Davey's scoring system was used to define the severity of SG in the abdomen by the same investigators. Patients with cervical dilatation of 6 cm or more were included in the preterm labor group. RESULTS: A total of 292 women were included in the study. Of these, 176 (60.3%) had no SG, 20 (6.8%) had mild SG, and 96 (32.9%) had severe SG. Davey's score was lower in the group of patients with preterm birth than in the term birth groups (p = .002). SG in the breasts was more common in the preterm labor group than in the term birth group (p = .007). Also, the presence of SG in the legs was less common in the preterm labor group than in the term birth group (p < .001). In a logistic regression model, stria in the breasts revealed most significant in preterm delivery. CONCLUSIONS: No difference was found in the pregnancy length in gestational weeks among groups of different SG severity. The Davey's score and the presence of striae in the legs and breasts were found different between the preterm and term birth groups, and the term birth subgroups.

Effect of re-approximation of the rectus muscles on diastasis recti abdominis at cesarean section - a prospective cross-sectional study.

OBJECTIVES: Caesarean section (CS) is one of the most frequently performed surgical procedures in the world and Turkey. In this study, we aimed to investigate the relationship between re-approximation of the rectus muscles during CS and the severity of diastasis recti abdominis in the first postoperative month. To investigate the relationship between re-approximation of the rectus muscles during CS and the severity of diastasis recti abdominis in the first postoperative month. MATERIAL AND METHODS: The study was designed as a prospective cross-sectional study. Patients were divided into two groups: parietal peritoneum closure only (Group 1), and closure of the parietal peritoneum and re-approximation of rectus muscle (Group 2). The distance between the rectus muscles and the thickest rectus muscle thickness were measured one month after CS from three anatomic regions using superficial ultrasonography by the same blinded physician. The anatomic regions were described as xiphoid, 3 cm above the umbilicus, and 2 cm below the umbilicus. The relation of the measurements between the groups was evaluated. RESULTS: There was a total of 128 patients, 64 in Group 1 and 64 in Group 2. There were no statistical differences between the groups in terms of the distance between rectus muscles and the thickness of rectus muscle at the described anatomic regions (p > 0.05). CONCLUSION: Re-approximation of rectus muscles has no effect on the prevention of diastasis recti, which is an important cosmetic problem.