Detalles de la búsqueda
1.
Exploring flavylium-based SWIR emitters: Design, synthesis and optical characterization of dyes derivatized with polar moieties.
Bioorg Chem
; 148: 107462, 2024 May 17.
Artículo
Inglés
| MEDLINE | ID: mdl-38776650
2.
Discovery of a septin-4 covalent binder with antimetastatic activity in a mouse model of melanoma.
Bioorg Chem
; 144: 107164, 2024 Mar.
Artículo
Inglés
| MEDLINE | ID: mdl-38306824
3.
Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein.
Molecules
; 27(23)2022 Dec 03.
Artículo
Inglés
| MEDLINE | ID: mdl-36500607
4.
Inflammasome Inhibitors.
Molecules
; 26(22)2021 Nov 16.
Artículo
Inglés
| MEDLINE | ID: mdl-34834004
5.
Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor.
Molecules
; 26(13)2021 Jun 29.
Artículo
Inglés
| MEDLINE | ID: mdl-34209843
6.
Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients: Rescue by α-Ketoglutarate and TET-TDG Functional Reactivation.
Circ Res
; 122(1): 31-46, 2018 01 05.
Artículo
Inglés
| MEDLINE | ID: mdl-29158345
7.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7.
Molecules
; 25(13)2020 Jun 28.
Artículo
Inglés
| MEDLINE | ID: mdl-32605268
8.
Development of covalent NLRP3 inflammasome inhibitors: Chemistry and biological activity.
Arch Biochem Biophys
; 670: 116-139, 2019 07 30.
Artículo
Inglés
| MEDLINE | ID: mdl-30448387
9.
In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition.
Pharmacol Res
; 103: 132-43, 2016 Jan.
Artículo
Inglés
| MEDLINE | ID: mdl-26621246
10.
Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents.
Bioorg Med Chem
; 21(7): 2107-16, 2013 Apr 01.
Artículo
Inglés
| MEDLINE | ID: mdl-23394865
11.
NLRP3 monomer functional dynamics: From the effects of allosteric binding to implications for drug design.
Int J Biol Macromol
; 246: 125609, 2023 Aug 15.
Artículo
Inglés
| MEDLINE | ID: mdl-37394218
12.
Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation.
Eur J Med Chem
; 257: 115542, 2023 Sep 05.
Artículo
Inglés
| MEDLINE | ID: mdl-37290185
13.
Multitarget Antioxidant NO-Donor Organic Nitrates: A Novel Approach to Overcome Nitrates Tolerance, an Ex Vivo Study.
Antioxidants (Basel)
; 11(1)2022 Jan 16.
Artículo
Inglés
| MEDLINE | ID: mdl-35052670
14.
Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades.
Oxid Med Cell Longev
; 2020: 9219825, 2020.
Artículo
Inglés
| MEDLINE | ID: mdl-32832010
15.
Furoxan-, alkylnitrate-derivatives and related compounds as anti-trypanosomatid agents: mechanism of action studies.
Bioorg Med Chem
; 16(17): 7900-7, 2008 Sep 01.
Artículo
Inglés
| MEDLINE | ID: mdl-18706821
16.
A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation.
Front Pharmacol
; 9: 1405, 2018.
Artículo
Inglés
| MEDLINE | ID: mdl-30559669
17.
α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis.
Cell Death Dis
; 9(7): 756, 2018 07 09.
Artículo
Inglés
| MEDLINE | ID: mdl-29988033
18.
Nitric oxide donor beta2-agonists: furoxan derivatives containing the fenoterol moiety and related furazans.
J Med Chem
; 50(20): 5003-11, 2007 Oct 04.
Artículo
Inglés
| MEDLINE | ID: mdl-17845020
19.
Nonsteroidal Anti-Inflammatory Drugs: Exploiting Bivalent COXIB/ TP Antagonists for the Control of Cardiovascular Risk.
Curr Med Chem
; 24(30): 3218-3230, 2017.
Artículo
Inglés
| MEDLINE | ID: mdl-28571535
20.
Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease.
J Med Chem
; 60(9): 3656-3671, 2017 05 11.
Artículo
Inglés
| MEDLINE | ID: mdl-28410442