RESUMEN
Primary localized cutaneous nodular amyloidosis is a rare plasma cell dyscrasia in which an amorphous material consisting of light chain amyloid is produced and deposited in the dermis, with varied clinical presentation. We describe the case with unusual and tumor lush clinical presentation in the face with no progression to systemic disease and no evidence of extracutaneous commitment.
Asunto(s)
Amiloidosis Familiar/patología , Dermis/patología , Dermatosis Facial/patología , Enfermedades Cutáneas Genéticas/patología , Adulto , Amiloidosis Familiar/cirugía , Dermis/cirugía , Dermatosis Facial/cirugía , Humanos , Masculino , Recurrencia , Enfermedades Cutáneas Genéticas/cirugía , Resultado del TratamientoRESUMEN
A 73-year-old male patient developed a poorly differentiated squamous cell carcinoma in the anal canal nine months ago. He was treated with two cycles of 5-fluorouracil and cisplatin and concomitant radiotherapy (6 MeV linear photon accelerator, total dose of 54 Gy), with complete remission. Since forty-five days he presentes a painful perianal and intergluteal erosion with circinate pustular borders. Light microscopy showed pseudoepitheliomatous hyperplasia of the epidermis with microabscesses of inflammatory cells (neutrophils and eosinophils) and acantholytic keratinocytes . Indirect immunofluorescence was positive for IgG, with an intercellular pattern, 1:80 titer. The diagnosis of radiotherapy-induced pemphigus vegetans was established and there was significant regression with oral prednisone (40 mg) and topical betamethasone.
Asunto(s)
Pénfigo , Anciano , Humanos , Hiperplasia , Masculino , Pénfigo/diagnóstico , Pénfigo/tratamiento farmacológico , Pénfigo/etiología , SupuraciónRESUMEN
Hailey-Hailey disease, or familial benign pemphigus, is a rare bullous genodermatosis that usually presents with flaccid blisters, erosions, and maceration limited to flexural areas, resulting in increased morbidity and reduced quality of life for affected patients. The authors report an unusual case of generalized Hailey-Hailey disease with erythroderma and fatal outcome.
Asunto(s)
Dermatitis Exfoliativa/patología , Pénfigo Familiar Benigno/patología , Acantólisis/patología , Infecciones Relacionadas con Catéteres , Dermatitis Exfoliativa/complicaciones , Dermatitis Exfoliativa/tratamiento farmacológico , Resultado Fatal , Femenino , Humanos , Persona de Mediana Edad , Pénfigo Familiar Benigno/complicaciones , Pénfigo Familiar Benigno/tratamiento farmacológicoRESUMEN
We present the case of an HIV-negative man with asymptomatic penile erythematoviolaceous papules associated with similar slightly verrucous papules in the interdigital space of the right foot. A biopsy of the penile lesion confirmed Kaposi's sarcoma. No other causes of immunosuppression were observed. Penile lesions of KS are rare in HIV-negative individuals but it should also be considered in the differential diagnosis. Careful follow-up is recommended.
Asunto(s)
Infecciones por VIH , Herpesvirus Humano 8 , Neoplasias del Pene , Sarcoma de Kaposi , Neoplasias Cutáneas , Diagnóstico Diferencial , Infecciones por VIH/complicaciones , Infecciones por VIH/diagnóstico , Humanos , Masculino , Neoplasias del Pene/diagnóstico , Sarcoma de Kaposi/diagnóstico , Neoplasias Cutáneas/diagnósticoRESUMEN
Annular epidermolytic ichthyosis is a rare subtype of epidermolytic ichthyosis that is characterized by erythematous, polycyclic, and migratory scaly plaques accompanied by palmoplantar keratoderma. This report presents the case of an 8-year-old girl who developed migratory, erythematous, scaly plaques associated with palmoplantar keratoderma. The initial hypothesis was erythrokeratodermia variabilis et progressiva; however, the finding of epidermolytic hyperkeratosis in histopathological examination led to the diagnosis of annular epidermolytic ichthyosis.
Asunto(s)
Hiperqueratosis Epidermolítica , Niño , Exantema , Femenino , Humanos , Queratodermia Palmoplantar , PielAsunto(s)
Artritis Reumatoide , Paniculitis , Piperidinas , Pirimidinas , Pirroles , Humanos , Piperidinas/uso terapéutico , Pirimidinas/uso terapéutico , Artritis Reumatoide/tratamiento farmacológico , Paniculitis/tratamiento farmacológico , Paniculitis/patología , Resultado del Tratamiento , Femenino , Pirroles/uso terapéutico , Neutrófilos/patología , Inhibidores de Proteínas Quinasas/uso terapéutico , Persona de Mediana Edad , BiopsiaAsunto(s)
Esporotricosis , Síndrome de Sweet , Humanos , Esporotricosis/patología , Síndrome de Sweet/patología , Masculino , Femenino , Biopsia , Persona de Mediana EdadRESUMEN
Verrucous hemangioma is a rare vascular skin disorder with an immune profile similar to vascular neoplasms, but with behavior and evolution of vascular malformations. Its main differential diagnosis is angiokeratoma circumscriptum neviforme, with an almost indistinguishable clinical presentation because both diseases appear as erythematous patches that evolve to violaceous plaques, becoming scaly and even verrucous, most commonly affecting the lower limbs. Histopathology is crucial for the correct diagnosis: while in angiokeratoma the vascular alterations are limited to the papillary dermis, verrucous hemangioma extends deep into the dermis, reaching the subcutaneous tissue.
Asunto(s)
Angioqueratoma/patología , Hemangioma/patología , Neoplasias Cutáneas/patología , Angioqueratoma/diagnóstico , Preescolar , Diagnóstico Diferencial , Femenino , Hemangioma/diagnóstico , Humanos , Neoplasias Cutáneas/diagnósticoRESUMEN
Zoon vulvitis or vulvitis chronica plasmacellularis is a rare, chronic benign inflammation of the vulvar mucosa, diagnosed histologically, with variable therapeutic responses. It is important to be diagnosed because it mimics the presentation of other genital conditions, such as lichen planus and squamous cell carcinoma, which require specific treatment. We report a case of a female patient with three asymptomatic shallow ulcers on the labia minora. Laboratory tests ruled out infectious diseases and the biopsy was consistent with Zoon Vulvitis.
Asunto(s)
Vulva/patología , Vulvitis/patología , Biopsia , Diagnóstico Diferencial , Femenino , Humanos , Persona de Mediana Edad , Células Plasmáticas/patologíaRESUMEN
Abstract A 73-year-old male patient developed a poorly differentiated squamous cell carcinoma in the anal canal nine months ago. He was treated with two cycles of 5-fluorouracil and cisplatin and concomitant radiotherapy (6 MeV linear photon accelerator, total dose of 54 Gy), with complete remission. Since forty-five days he presentes a painful perianal and intergluteal erosion with circinate pustular borders. Light microscopy showed pseudoepitheliomatous hyperplasia of the epidermis with microabscesses of inflammatory cells (neutrophils and eosinophils) and acantholytic keratinocytes . Indirect immunofluorescence was positive for IgG, with an intercellular pattern, 1:80 titer. The diagnosis of radiotherapy-induced pemphigus vegetans was established and there was significant regression with oral prednisone (40 mg) and topical betamethasone.
RESUMEN
Melanocytic nevi result from the proliferation of melanocytes at the dermal-epidermal junction and/or in the dermis and very rarely affect the nail matrix and bed. Intradermal nevi are tumors often diagnosed in routine clinical dermatological practice, with typical clinical and histopathologic aspects, and found in a wide variety of skin sites. We report a case of intradermal melanocytic nevus of the proximal nail fold with uncommon intraoperative gross findings and without involvement of the nail bed or matrix, showing intradermal component only, which draws our attention to the possible different presentation of melanocytic lesions. No description of intradermal nevi at this site has been reported in the literature so far.
RESUMEN
Abstract We present the case of an HIV-negative man with asymptomatic penile erythematoviolaceous papules associated with similar slightly verrucous papules in the interdigital space of the right foot. A biopsy of the penile lesion confirmed Kaposi's sarcoma. No other causes of immunosuppression were observed. Penile lesions of KS are rare in HIV-negative individuals but it should also be considered in the differential diagnosis. Careful follow-up is recommended.
Asunto(s)
Humanos , Masculino , Neoplasias del Pene , Sarcoma de Kaposi/diagnóstico , Neoplasias Cutáneas/diagnóstico , Infecciones por VIH/complicaciones , Infecciones por VIH/diagnóstico , Herpesvirus Humano 8 , Diagnóstico DiferencialRESUMEN
Abstract Hailey-Hailey disease, or familial benign pemphigus, is a rare bullous genodermatosis that usually presents with flaccid blisters, erosions, and maceration limited to flexural areas, resulting in increased morbidity and reduced quality of life for affected patients. The authors report an unusual case of generalized Hailey-Hailey disease with erythroderma and fatal outcome.