[Features of secondary prevention of cardiovascular disease in elderly individuals with high cardiovascular risk.]

Studied the causes of the ineffectiveness of follow-up of elderly patients with pathology of the cardiovascular system with high cardiovascular risk. The necessity of an individual approach, the individual preventive counseling in the usual patient conditions, learning to use tools of self-control belonging to that particular patient. Conducting a «pharmacological control¼ every visit to an elderly patient at home or a visit to the clinic.

[Oral diseases structure in patients with diffuse liver lesions before and after transplantation]. / Osobennosti struktury stomatologicheskikh zabolevanii u patsientov s diffuznymi porazheniiami pecheni do i posle transplantatsii.

Purpose of the study was to identify dental risk factors for complications at the stage of rehabilitation adaptation in patients with diffuse liver lesions. The study included 52 patients with diffuse liver lesions aged 25-55 years, who were divided between two groups of 26 persons with different dental status, depending on the main disease stage of treatment. RESEARCH METHODS: Clinical, x-ray, morphological, analytical, statistical. RESULTS: It has been reliably established that low level of oral hygiene, high intensity and prevalence of caries and its complications (foci of odontogenic infection), inflammatory periodontal diseases joined with severe teeth hyperesthesia, dominate in patients before liver transplantation, which confirms low level of sanitation on stages of preparation for surgical treatment. Chronic odontogenic infection in periodontal tissues with phenomena of epithelial cells dystrophy, candidiasis of the oral mucosa, foci of odontogenic infection, low level of oral hygine, tendency to precancerous diseases development are the risk factors for complications arise on the stage of rehabilitation adaptation in patients with diffuse liver lesions. CONCLUSION: The revealed relationship between diffuse liver lesions and dental status of patients, at the stages of preparation and after liver transplantation indicates, that a low level of oral cavity sanitation, the presence of odontogenic infection and periodontal disease worsen the course of the main disease, increase the risk of transplant rejection and require the creation of a dental rehabilitation system for this category of patients.

[Vitamin D deficiency as a risk factor for chronic non-infectious diseases.]

Vitamin D deficiency is an important risk factor for a number of chronic non-infectious diseases. The results of the study showed a high prevalence of vitamin D deficiency in patients with cardiovascular and bronchial obstruction diseases. Patients with coronary artery disease in association with hypertension were diagnosed with a vitamin D deficiency in 60% of cases, a pronounced deficiency in 40%; in patients with arterial hypertension - a vitamin D deficiency in 80%, and a pronounced deficit - in 20%; in patients with chronic obstructive pulmonary disease - vitamin D deficiency in 33%, and a pronounced deficit - in 67%; in patients with bronchial asthma - vitamin D deficiency in 75%, a severe deficit in 25%, and a vitamin D deficiency in 25% of the subjects. According to the received results, vitamin D deficiency is associated with intensity of chronic heart failure, arterial hypertension in patients with cardiovascular diseases, and also with the degree of respiratory failure accompanying glucocorticoid therapy in patients with bronchial obstructive pathology. The intensity of hypovitaminosis of vitamin D is aggravated with age and the duration of menopause in women. The article shows that patients with chronic non-infectious diseases have a high risk of osteoporotic fractures, most patients with bronchial obstructive and cardiovascular diseases need anti-osteoporotic therapy and osteodensitometry.

[The problem of osteoporosis in patients with cardiovascular and broncho-obstructive disease].

The article deals with the problem of osteoporosis in patients with cardiovascular and broncho-obstructive disease. The risk factors and clinical functional features of osteoporosis are analyzed in patients with coronary heart disease, hypertension, chronic obstructive pulmonary disease, bronchial asthma. Indicators of bone mineral density in patients with cardiovascular and broncho-obstructive disease on average meet the criteria for osteopenia. Most examinees had a high risk of osteoporotic fractures as a result of significant reduction in bone mineral density. The presence of osteoporosis in patients with cardiovascular and broncho-obstructive pathology from the point of co-morbidity results in a syndrome of mutual aggravation that determines the need for a comprehensive diagnosis, treatment and prevention.

[Clinical and functional characteristics of chronic obstructive pulmonary disease in association with pathology of the cardiovascular system in persons of advanced age].

The study was aimed at clinic-functional features of chronic obstructive pulmonary disease (COPD) in association with an arterial hypertension and an ischemic heart disease in persons of advanced age. 69 women and 82 men have been examined through clinic-laboratory, functional and tool methods of inspection. Distinctions in frequency of combined pathologies in the group of women of advanced age have been revealed in comparison with men. Presence of combined pathologies in women of advanced age with chronic obstructive illness of lungs aggravates its clinical current. The accompanying ischemic heart trouble influences the clinical picture of COPD in a greater extent.

[Experience of studies of longevity phenomenon in Tiumen'. Health status of long-livers: influence of hereditary, ecological, climatic and social factors on life span]. / Opyt izucheniia fenomena dolgozhitel'stva dolgozhitelei: vliianie nasledstvennykh, ékologo-klimaticheskikh, sotsial'nykh faktorov na prodolzhitel'nost' zhizni.

Aging of population in Tyumen region and a growing number of long livers, marked in last decade, make research of medical and social aspects of this age persons actual. Complex examination of 84 persons (age 90-102 years) was made. High longevity of parents, absence of chronic internal diseases complications in them, mechanisms of adaptation to severe climatic conditions due to the long living in Tyumen region are important factors for determination of longevity phenomenon.

[Functional polymorphism of p53 and CCR5 genes in the long-lived of the Siberian region]. / Funktsional'nyi polimorfizm genov p53 i CCR5 u dolgozhitelei Sibirskogo regiona.

The P53 protein is a key regulator of modified-cell apoptosis. The functional oligonucleotide polymorphism of the p53 gene causes the substitution of arginine (Arg) for praline (Pro) in the codon 72. A reduced apoptotic activity of p53 and, as a consequence, development of oncology pathology is associated with the above polymorphism. CCR5 is a compound transmembrane receptor-protein, which apart from chemokines, binds with some molecules and is a coreceptor for HIV-1. 32 bp deletion within the CCR5 encoding region results in the loss of the protein's receptor function. It has been demonstrated that the transmission of the "external" (in respect to cell) stimulus, via the CCR5 system, induces expression of the p53 gene and initiates apoptosis. Allele variants and p53 and CCR5 genotypes (separately and in combinations) were investigated, within the present case study, for 131 long-livers from Novosibirsk and Tyumen Regions. A trend was detected towards accumulation of the p53 Pro alleles in association with the CCR5del32 allele in the study group, which, as the authors believe, can enhance the genome resistance to variable factors that cut the life span.

[Cell-membrane aspects of the pathogenesis of hypoxia in vibration disease induced by local vibration]. / Kletochno-membrannye aspekty patogeneza gipoksii pri vibratsionnoi bolezni ot vozdeistviia lokal'noi vibratsii.

A study was made of the blood and tissue oxygen regime in patients with vibratory disease (VD) induced by local vibration and of the importance of lipid peroxidation (LPO) in oxygenation disorders. Venous hyperoxia, a decrease of the arteriovenous difference according to oxygen, the percentage of oxygen utilization by tissues, shift of the acid-base balance towards metabolic acidosis were established, attesting to tissue hypoxia that increased with the gravity of VD. The importance of a steady activation of LPO and depression of the antioxidant system in the pathogenesis of hypoxia associated with VD was supported by the correlation analysis data on oxygen balance and LPO, the functional and metabolic characteristics of red blood cells (according to the viscosity of red blood cell suspension and the content in the cells of SH-groups, lipoproteins and histidine) and platelets (according to aggregation in response to ADP and thrombin) as well as by the level of blood serum fluorescence. The authors provide evidence for the use of antioxidants (a complex of alpha-tocopherol with ascorbic acid and methionine and calcium antagonists of the nifedipine group), giving a membranostabilizing effect, in multimodality treatment of patients afflicted with VD.

[Treatment of vibration-induced disease with corinfar]. / Lechenie vibratsionnoi bolezni korinfarom.

Examination results of corinphar efficacy in the treatment of 25 patients with vibration disease caused by local vibration of mean- and high-frequency range were described. The daily dose of corinphar was 30 mg, the course of treatment lasted 17-21 days. Positive effect was noted in 23 patients. During the treatment course peripheric hemodynamics, microhemocirculation and transcapillary metabolism improved, intensity of lipid peroxidation reactions decreased because of vasodilating, desaggregate and antioxidant impact of the preparation.