RESUMEN
PURPOSE: Pain is a major physiological stressor that can worsen critical medical conditions in many ways. Currently, there is no reliable monitoring tool which is available for pain monitoring in the deeply sedated ± curarized critically ill patients. This study aims to assess the effectiveness of the multiparameter nociception index (NOL®) in the critical care setting. We compared NOL with traditionally used neurovegetative signs and examined its correlation with sedation depth measured by bispectral index (BIS®) electroencephalographic (EEG) monitoring. METHODS: This retrospective monocentric cohort study was conducted in a general intensive care unit, including patients who required moderate-to-deep levels of sedation with or without continuous neuromuscular blockade. The performance of NOL was evaluated both in the entire studied population, as well as in two subgroups: curarized and non-curarized patients. RESULTS: NOL demonstrated greater accuracy than all other indicators in pain detection in the overall population. In the non-curare subgroup, all indices correctly recognized painful stimulation, while in the patients subjected to neuromuscular blocking agent's infusion, only NOL properly identified nociception. In the former group, EEG's relation to nociception was on the border of statistical significance, whereas in the latter BIS showed no correlation with NOL. CONCLUSION: NOL emerges as a promising device for pain assessment in the critical care setting and exhibits its best performance precisely in the clinical context where reliable pain assessment methods are most lacking. Furthermore, our research confirms the distinction between sedation and analgesia, highlighting the necessity for distinct monitoring instruments to accurately assess them.
RESUMEN
Monopulmonary patients undergoing major abdominal surgery represent a high-risk population. While general anesthesia is typically the standard approach, mechanical ventilation can cause significant complications, particularly in patients with pre-existing lung conditions. Tailored anesthesia strategies are essential to mitigate these risks and preserve respiratory function. We present the case of a 71-year-old female with a history of prior right pneumonectomy for lung cancer. She was scheduled for combined left nephrectomy and left hemicolectomy laparotomic surgery because of extended colon cancer. The patient was prepared according to the local Enhanced Recovery After Surgery (ERAS) protocol and underwent thoracic neuraxial anesthesia with sedation maintaining spontaneous breathing, so avoiding general anesthesia and mechanical ventilation. Anesthesia in the surgical field was effective, and no respiratory problems occurred intraoperatively. The patient's rapid recovery and early discharge underscore the success of our "tailored anesthesia strategy." Our experience highlights the feasibility and benefits of tailored anesthesia in monopulmonary patients undergoing major abdominal surgery. By avoiding general anesthesia and mechanical ventilation, we mitigated risks and optimized patient outcomes, emphasizing the importance of individualized approaches in high-risk surgical populations.