[Cordaron and nonachlasine in treatment of chronic coronary insufficiency]. / Kordaron i nonakhlazin v lechenii bol'nykh s khronicheskoi koronarnoi nedostatochnost'iu

In a double blind study of the clinical effect of Cordaron conducted in 55 patients with chronic ischaemic heart disease a positive effect was obtained in 80.4% of the cases, an effect of placebo-in 24.3%. Cordaron was especially effective in patients with localized stenoses of the coronary arteries. Nonachlasine (an activator of the cardiac beta-adrenergic receptors) proved effective in 10 of 13 patients with chronic ischaemic heart disease.

[Comparative study of the effectiveness of korinfar, izoptin and obzidan in patients with variant stenocardia combined with effort stenocardia]. / Sravnitel'noe izuchenie éffektivnosti korinfara, izoptina i obzidana u bol'nykh s variantnoi stenokardiei, sochetaiushcheisia so stenokardiei napriazheniia.

Twelve patients with variant angina combined with angina of effort were examined. Repeated exercise tests prior to the administration of antianginal drugs revealed the spontaneous variability of the patients' tolerance to the exercise and of the pulse-pressure index at the exercise peak which may serve as an indirect sign of the angiospastic factor involvement in clinical manifestations of angina of effort. The treatment of such patients with corinfar and isoptin was associated with the elimination and significant reduction of spontaneous attacks of angina attended by a considerable increase in the exercise tolerance and in the pulse-pressure index at the exercise peak. The treatment with obsidan in these cases was less effective: the incidence of spontaneous anginal attacks changed insignificantly, the tolerance to exercise increased with the reduction of the maximum value of the pulse-pressure index.

[The state of microcirculation, hemoperfusion and tissue oxygen consumption in patients with ischemic heart disease and angina pectoris]. / Sostoianie mikrotsirkuliatornogo rusla, gemoperfuzii i kislorodnogo rezhima tkani u bol'nykh ishemicheskoi bolezn'iu serdtsa so stenokardiei.

In patients with associated coronary heart disease and angina pectoris functional classes II-IV, microcirculatory disorders are linked with the gravity of the patients' clinico-functional status. Application of the functional tests (inhalation of 100% moistened oxygen, regional occlusion of the vessels of the limb under study) revealed the presence of latent deficiency of oxygen transport to the cellular substrate. In functional classes III and IV of disease, an appreciable reduction in the level of tissue hemoperfusion, of tissue oxygen supply, and an increase in the summary conjunctival index were recorded.

[Progression of coronary arteriosclerosis based on the data from repeat coronary angiography and the clinical course of ischemic heart disease]. / Progressirovanie ateroskleroza koronarnykh arterii serdtsa po dannym povtornoi koronarografii i klinicheskoe techenie ishemicheskoi bolezni serdtsa.

The clinical and instrumental studies data are compared with the repeated coronarography data in 16 patients with coronary heart disease associated with stable angina pectoris. Repeated coronarography was performed within 4 to 8 years (5.2 years on the average). In 14 out of the 16 patients (87.5%), repeated coronarography revealed the development of coronary atherosclerosis which was accompanied clinically by the patients' status deterioration, the decreased exercise tolerance, the occurrence of new cases of myocardial infarction, appearance of the symptoms of heart insufficiency and heart rhythm disorders.