RESUMEN
Bone density testing is safe, accurate, and useful. Specific clinical indications and the types of equipment available to assess them are reviewed. A positive effect on the practice of a clinical rheumatologist with resultant improved patient care appears likely in light of the information available.
Asunto(s)
Densidad Ósea , Absorciometría de Fotón , Fracturas Óseas/etiología , Humanos , Osteoporosis/complicaciones , Osteoporosis/diagnóstico , Reumatología/métodos , Tomografía Computarizada por Rayos XRESUMEN
Flurbiprofen and ibuprofen were compared in a six-week double-blind randomized study in 208 patients with rheumatoid arthritis. Daily dosages were 120 mg flurbiprofen and 2400 mg ibuprofen for six weeks. Both drugs were effective in providing partial control of RA symptoms. Either or both drugs produced statistically significant improvement in mean values of time of onset of fatigue, grip strength and tender and swollen joint counts. All other standard endpoints of efficacy (except ESR) were improved but not at a statistically significant level. Slightly more than half of the patients improved during the trial. There was no statistically significant difference in the efficacy of the drugs. The incidence of side effects was low with both drugs. Most side effects were related to gastrointestinal tract irritation.
Asunto(s)
Artritis Reumatoide/tratamiento farmacológico , Flurbiprofeno/uso terapéutico , Ibuprofeno/uso terapéutico , Fenilpropionatos/uso terapéutico , Propionatos/uso terapéutico , Artritis Reumatoide/fisiopatología , Ensayos Clínicos como Asunto , Evaluación de Medicamentos , Femenino , Flurbiprofeno/efectos adversos , Humanos , Ibuprofeno/efectos adversos , Masculino , Persona de Mediana Edad , Cooperación del PacienteRESUMEN
Retinal lesions occur in 25 to 30% of patients with systemic lupus erythematosus (SLE). Visual loss, however, is rare. A patient who developed central retinal vein occlusion and blindness during the course of active SLE is described. The pertinent literature is reviewed with attention to possible pathophysiologic mechanisms.
Asunto(s)
Isquemia/etiología , Lupus Eritematoso Sistémico/complicaciones , Vena Retiniana , Adolescente , Ceguera/etiología , Humanos , Masculino , Hemorragia Retiniana/etiologíaRESUMEN
Our data demonstrate that adequate control of uric acid production and serum acid concentration in primary gout arrests further deterioration of renal function and in some instances permits subsequent improvement in renal hemodynamic function even when renal impairment is clearly established. In considering the nature of the lesions of urate nephropathy, our study suggests that control of serum uric acid with drug therapy before renal involvement is apparent might prevent or significantly delay the morbidity and mortality of this complication of primary gout.