[Effect of thyrocalcitonin on the functions of the intact and hypertrophied myocardium]. / Vliianie tirokaltsitonina na funktsii intaktnogo i gipertrofirovannogo miokarda.

Examination of 20 individuals without any pathological conditions of the cardiovascular system and 8 patients with myocardial hypertrophy has shown that the hypocalciemic hormone of the thyroid gland thyrocalcitonin has a certain negative inotropic effect and does not possess chrono- and dromotropic affects. The mechanism of the cardiac effect of thyrocalcitonin is evidently due to its effect on the metabolism of calcium and its transportation in the myocardial structures.

[The effect of single and long-term thyrocalcitonin administration on glucose tolerance and insulin secretion]. / Vliianie odnokratnogo i dlitel'nogo vvedeniia tirokal'tsitonina na tolerantnost' k gliukoze i sekretsiiu insulina

In male rats, i. m. administration of thyrocalcitonin (TCT)--2 and 10 units/kg for 1, 5, 10 and 15 days, reduced calcium level in the blood serum. In the TCT-treated rats the glucose-tolerance curves after i. p. injection of glucose became diabetoid-like. TCT inhibited the increase of insulin-like activity of the serum after glucose injection. The data suggest that TCT, lowering the calcium content of blood serum, inhibited the glucose-induced secretion of insulin.

[The effect of hormones regulating calcium metabolism on the growth and metastasis of experimental tumors]. / Vliianie gormonov, reguliruiushchikh obmen kal'tsiia, na rost i metastazirovanie opukholei v éksperimente

Injection of parathormone and thyrocalcitonin into rats with DMBA induced sarcomas resulted in a considerable stimulation of the metastasization process. It was found that the level of total Ca++ in tumor tissue was reduced under the influence of PTH. Under conditions of chronic exogenous hyperparathyroidism autoimmunereactions were suppressed. A prolonged administration of TCT did not alter considerable the total Ca++ content in tumor and markedly activated the autoantibody production in immunocompetent cells.