RESUMEN
Examination of 20 individuals without any pathological conditions of the cardiovascular system and 8 patients with myocardial hypertrophy has shown that the hypocalciemic hormone of the thyroid gland thyrocalcitonin has a certain negative inotropic effect and does not possess chrono- and dromotropic affects. The mechanism of the cardiac effect of thyrocalcitonin is evidently due to its effect on the metabolism of calcium and its transportation in the myocardial structures.
Asunto(s)
Calcitonina/uso terapéutico , Cardiomegalia/tratamiento farmacológico , Corazón/efectos de los fármacos , Adulto , Anciano , Cardiomegalia/fisiopatología , Ensayos Clínicos como Asunto , Relación Dosis-Respuesta a Droga , Evaluación de Medicamentos , Prueba de Esfuerzo , Femenino , Corazón/fisiología , Frecuencia Cardíaca/efectos de los fármacos , Humanos , Masculino , Persona de Mediana Edad , Contracción Miocárdica/efectos de los fármacos , Factores de TiempoRESUMEN
In male rats, i. m. administration of thyrocalcitonin (TCT)--2 and 10 units/kg for 1, 5, 10 and 15 days, reduced calcium level in the blood serum. In the TCT-treated rats the glucose-tolerance curves after i. p. injection of glucose became diabetoid-like. TCT inhibited the increase of insulin-like activity of the serum after glucose injection. The data suggest that TCT, lowering the calcium content of blood serum, inhibited the glucose-induced secretion of insulin.
Asunto(s)
Glucemia/metabolismo , Calcitonina/farmacología , Insulina/metabolismo , Islotes Pancreáticos/metabolismo , Animales , Calcitonina/administración & dosificación , Femenino , Secreción de Insulina , Masculino , RatasRESUMEN
Injection of parathormone and thyrocalcitonin into rats with DMBA induced sarcomas resulted in a considerable stimulation of the metastasization process. It was found that the level of total Ca++ in tumor tissue was reduced under the influence of PTH. Under conditions of chronic exogenous hyperparathyroidism autoimmunereactions were suppressed. A prolonged administration of TCT did not alter considerable the total Ca++ content in tumor and markedly activated the autoantibody production in immunocompetent cells.