[Implementation of hygiene procedures, microbial and physical controls and environmental monitoring in radiopharmacy department]. / Mise en oeuvre de procédures d'hygiène et de contrôles physiques et microbiologiques d'environnement au sein d'une unité de radiopharmacie.

Preparation of radiopharmaceuticals for injection involves compliance with the regulations for pharmaceutical drugs and radionuclides. The microbiological quality must be ensured, radiation exposure limited, and radioactive contamination of personnel and the environment prevented. Based on work concerning compliance and in accordance with changes in recent regulations, the facilities of the radiopharmacy department of the Louis Mourier Hospital have been optimized. Physical and microbiological controls of equipment and facilities have been implemented to monitor workstations and their environment with respect to microbiological quality. Three hygiene guidelines have also been implemented: improving hygiene practices, personal clothing, practical training on hygiene and its evaluation.

[Drugs and closed-angle glaucoma risk]. / Médicaments et risque de glaucome par fermeture de l'angle.

Closed-angle glaucomas arise among predisposed patients (narrow iridocorneal angle) in response to various stimuli. Most of the attacks are of iatrogenic origin: all the topical and systemic mydriatic drugs can provoke an angle closure glaucoma attack. Dangerous active ingredients with closed-angle glaucoma are active substances with anticholinergic activity (peripheral action, central action, with anticholinergic side-effects), active ingredients with sympathomimetic alpha activity (alpha 1, alpha and beta with indirect effects), and the active ingredients with parasympathomimetic activity (anticholinesterases). The proprietary medicine, whether or not they are included in the French dictionary Vidal((R)), are classified according to the administration route and their different indications. The closed-angle glaucoma risk after administration of these drugs is noted in the items'contraindications and precautions in the summary of the product characteristics enclosed in the marketing authorization.