TERTp mutation is associated with a shorter progression free survival in patients with aggressive histology subtypes of follicular-cell derived thyroid carcinoma.

PURPOSE: Evaluate the impact of TERTp mutation on the outcomes after initial treatment of 45 patients with thyroid carcinomas derived from follicular cells (TCDFC) with aggressive histology, in which the role of this mutation is not yet well defined. METHODS: Analysis of the presence of TERTp (-124C > T and -146C > T), BRAF (V600E), and NRAS (Q 61R) mutations by Sanger sequencing and analysis of their correlation with the patient's outcomes. RESULTS: Forty-five patients with aggressive histopathologic variants were included in the study. Of these, 68.9% had aggressive variants of papillary thyroid cancer (PTC), 22.2% had poorly differentiated thyroid carcinoma (PDTC)/insular carcinoma, and 8.9% had invasive follicular thyroid cancer (FTC) with Hurthle cell features (Hurthle cell carcinoma). Lymph node metastases were present in 46.7% and distant metastases in 54.6%. The response to the initial therapy was excellent in 45.5% and structurally incomplete in 50%. During the follow-up period (median of 56 months; 5-360 months), 47.7% presented with disease progression and 17.8% experienced disease-related death. In 53.3% of the cases at least one molecular alteration (TERTp in 33.4%, BRAF in 24.5%, RAS in 8.9%) was detected. In the multivariate analysis, TERTp mutation was the factor associated with the highest risk (6 times) of having structural disease after initial therapy (p = 0.01), followed by vascular invasion (p = 0.02), gross extrathyroidal extension (ETE) (p = 0.02) and distant metastasis (p = 0.04). Regarding mutational status, only TERTp mutation was associated with disease progression, and diminished disease progression-free survival (PFS). The presence of distant metastasis, vascular invasion and gross ETE were significantly associated with the risk of disease progression. CONCLUSIONS: TERTp mutation appears be an indicator of both persistence and progression of structural disease after initial therapy in aggressive variants of TCDFC, and associates with a shorter progression free survival regardless of the therapy employed.

Validación cognitiva de un protocolo instruccional de reexperimentación emocional en adultos víctimas de violencia política en Colombia / Cognitive validation of an instructional protocol for emotional disclosure in adult victims of political violence in Colombia

Resumen La re experimentación emocional (RE) permite dar sentido a hechos traumáticos o estresantes mediante un proceso dirigido por instrucciones verbales o escritas, y por ello puede generar beneficios en el bienestar psicológico y la salud física autoinformada. El objetivo del presente estudio fue evaluar la comprensión de tres tipos de instrucciones experimentales (RE tradicional, RE con claves de aceptación y compromiso, y RE psicosocial) y una instrucción para el grupo control (RE trivial), mediante técnicas de validación cognitiva (pruebas centradas en el significado y verbalización de pensamiento) en personas expuestas a hechos de violencia política en Colombia. Para ello, se desarrolló un estudio de tipo cualitativo con corte instrumental, en el que se entrevistó a 42 colombianos víctimas de violencia política, en su mayoría mujeres, elegidos con un muestro por conveniencia. Las entrevistas fueron transcritas y codificadas mediante un análisis categorial mixto que tomó como referente procedimientos del Movimiento de Aspectos Cognitivos de la Metodología de Encuestas. Como resultado, los participantes comprendieron de manera diferencial las instrucciones dadas en cada protocolo, enfocándose en aspectos como el contexto sociopolítico en el caso del protocolo psicosocial, y en respuestas asociadas a la aceptación en el protocolo con claves de aceptación y compromiso. Se identificaron dificultades en la comprensión de algunas secciones de los protocolos, las cuales fueron ajustadas. Finalmente, se enfatiza la importancia de implementar técnicas de validación cognitiva para verificar la comprensión de instrucciones, protocolos o instrumentos, dado que el desempeño de los participantes y la calidad de las medidas de las intervenciones pueden verse afectados por la comprensión e interpretación de las instrucciones propuestas.

Abstract Emotional disclosure (ED) allows making sense of traumatic or stressful events through a process guided by verbal or written instructions, and thus may generate benefits in psychological well-being and self-reported physical health. The aim of the present study was to evaluate the understanding of three types of experimental instructions (traditional ED, ED with acceptance and commitment cues, and psychosocial ED) and one instruction for the control group (trivial ED), trough cognitive validation techniques (tests focused on meaning and verbalización of thought), in people exposed to events of political violence in Colombia. For this purpose, a qualitative study with an instrumental approach was developed, in which 42 Colombian victims of political violence, mostly women, were interviewed, chosen through convenience sampling. The interviews were transcribed and analyzed by means of a mixed categorical analysis that used as a reference procedures from the Cognitive Aspects of the Survey Methodology Movement. As a result, participants differentially understood the instructions given in each protocol, focusing on aspects such as the sociopolitical context in the case of the psychosocial protocol, and on responses associated with acceptance in the protocol with acceptance and commitment cues. Difficulties were identified in the understanding of some sections of the protocols, which were adjusted. Finally, the importance of implementing cognitive validation techniques to verify the understanding of instructions, protocols or instruments is emphasized, given that the performance of the participant and the quality of the measures of the experiments may be affected by the understanding and interpretation of the proposed instructions.

Spanish adaptation of the subjective value inventory / Adaptación española del Subjective Value Inventory

BACKGROUND: Different studies have highlighted the importance of subjective outcomes in negotiations. The Subjective Value Inventory (SVI) is the only existing instrument for measuring this aspect. The aim of this research was to analyze the psychometric properties and gender factorial invariance of the SVI in a Spanish sample. METHOD: A double back-translation of the original tool was carried out and it was then applied to a diverse sample of 345 university students and professionals of both genders. Analysis of factorial validity, reliability, and factorial invariance of the model across gender were carried out. RESULTS: A model of sixteen items grouped into four factors, equivalent to the original, was confirmed. All the factors of the model, except the Self, demonstrated adequate psychometric indices. The configural invariance across gender is acceptable. CONCLUSIONS: The Spanish version of the SVI matches the original scale. However, this study proposes using the scale without the Self factor. Lastly, the scale shows configural invariance across gender

ANTECEDENTES: diferentes estudios han destacado la importancia de los resultados subjetivos en las negociaciones. El Subjective Value Inventory (SVI) es el único instrumento para medir este aspecto. El objetivo de esta investigación fue analizar las propiedades psicométricas y la invarianza factorial de género del SVI en una muestra española. MÉTODO: se realizó la doble traducción de la herramienta original y luego se aplicó a una muestra de 345 universitarios y profesionales de ambos géneros. Se realizaron análisis de validez factorial, de fiabilidad y de invarianza factorial del modelo en relación al género. Todos los factores del modelo, excepto el Self, mostraron unos índices psicométricos adecuados. La invarianza configural en relación al género es aceptable. RESULTADOS: se confirmó un modelo de dieciséis ítems agrupados en cuatro factores, equivalente al original. CONCLUSIONES: la versión española del SVI se ajusta a la escala original. Sin embargo, en este estudio se propone utilizar la escala sin el factor Self. Finalmente, la escala muestra invarianza configural en relación al género