Prevalence of cardiovascular risk factors in superior vestibular neuritis: A cross-sectional study following STROBE guidelines.

OBJECTIVE: To compare the prevalence of cardiovascular risk factors (CVRF) in patients with superior vestibular neuritis (SVN) versus the general French population, and to examine the possibility of vascular etiology in acute superior vestibular deficit. MATERIAL AND METHODS: A single-center retrospective study compared the prevalence of hypercholesterolemia, hypertension, diabetes, smoking, cardiovascular disease and atrial fibrillation between patients with SVN and the French general population. Inclusion criteria comprised: rotatory vertigo lasting several days, without hearing impairment or neurological signs, with anterior and lateral semicircular canal involvement on video-Head-Impulse-Test (vHIT). A senior radiologist analyzed superior vestibular nerve and inner ear structure enhancement on cerebellopontine MRI. RESULTS: One hundred and eighteen cases of SVN were included from May 2016 to February 2020. Statistical analyses concerned 106 cases. The SVN population had significantly less hypercholesterolemia (RR=0.40) than the general French population. There was no significant difference concerning other CVRFs. Superior vestibular nerve enhancement was observed on 84% of MRIs. CONCLUSION: Prevalence of CVRF was not higher in patients with SVN than in the general population. The present study highlighted involvement of the superior vestibular nerve more than of the anterior vestibular artery in SVN.

Vestibulo-ocular reflex and balance maturation in healthy children aged from six to twelve years.

OBJECTIVES: Because both the vestibulo-ocular and vestibulospinal pathways depend on neurological maturation during childhood, the purpose of this study was to evaluate the vestibulo-ocular reflexes (VOR) and balance parameters of children aged from 6 to 12 years. METHODS: 147 healthy children were included in the study. The visual vestibulo-ocular reflex (VVOR) and VOR were recorded during sinusoidal rotation (videonystagmography), with calculation of the gain. The sensory organization on postural control was studied using computerized dynamic posturography (EquiTest), with equilibrium scores (ES) and sensory organization tests. RESULTS: Data were analyzed according to age groups: group a from 6 to 8 years, group b from 9 to 10 years, and group c from 11 to 12 years. Whereas VVOR gain was comparable in the three groups, VOR gain was lower in groups b and c compared to group a. Global ES increased with age. Analyzing each sensory component for postural control, the only score that increases with age is the vestibular one. Somesthetic and visual scores remained comparable in the three groups. CONCLUSIONS: Our results in a large cohort of children confirm previous ones: VOR gain is higher in young children, whereas ES is lower. Moreover, it seems that the 10- to 12-year-old children use their vestibular inputs more compared to younger ones. From these results it can be suggested that both the vestibulo-ocular and vestibulospinal pathways are still maturing between 6 and 12 years.

Wegener's granulomatosis of the temporal bone and skull base that mimicked an inflammatory myofibroblastic tumour: a case report.

OBJECTIVE: To compare two potential diagnoses of a temporal bone pseudotumour: an inflammatory myofibroblastic tumour and Wegener's granulomatosis. METHODOLOGY: A case of Wegener's granulomatosis that mimicked an inflammatory myofibroblastic tumour is reported. The clinical presentation, staging of the disease, histology, and follow-up are analysed. RESULTS: Histopathology of the temporal bone failed to provide an accurate diagnosis, even after immunocytochemical analyses. The diagnosis of Wegener's granulomatosis was suspected after biopsy of a pulmonary mass and was confirmed by the presence of anti-neutrophil cytoplasmic antibodies in blood samples. CONCLUSION: Irrespective of the aetiology, a pseudotumour of the temporal bone should always be investigated by biology and radiology. Radiological investigations will allow staging of the disease and specific localisation for biopsies.

Consensus statement. Corticosteroid therapy in ENT in the context of the COVID-19 pandemic.

This consensus statement about the indications and modalities of corticosteroid treatment in the context of the COVID-19 pandemic was jointly written by experts from the French Association of Otology and Oto-Neurology (AFON) and from the French Society of Otorhinolaryngology, Head and Neck Surgery (SFORL). There is currently not enough data in favour of danger or benefit from corticosteroids in COVID-19, so until this matter is resolved it is advisable to limit their indications to the most serious clinical pictures for which it is well established that this type of treatment has a positive impact on the progression of symptoms. In Grade V and VI Bell's palsy according to the House-Brackmann grading system, a week's course of oral corticosteroids is recommended. Corticosteroid therapy is also recommended in cases of sudden hearing loss of more than 60dB, either in the form of intratympanic injections or a week's course of oral medication. In rhinology, there is no indication for systemic corticosteroid therapy in the current situation. However, patients are advised to continue with their local corticosteroid therapy in the form of a nasal spray or by inhalation. Treatments with corticosteroid nasal sprays can still be prescribed if there is no alternative. Finally, systemic or local corticosteroid therapy is not indicated for bacterial ENT infections.

French Society of ENT (SFORL) guidelines. Management of acute Bell's palsy.

AQFThe authors present the guidelines of the French Society of ENT and Head and Neck Surgery (SFORL) regarding the management of Bell's palsy in adults. After a literature review by a multidisciplinary workgroup, guidelines were drawn up based on retrieved articles and group-members' experience, then read over by an independent group to edit the final version. Guidelines were graded A, B, C or "expert opinion" according to decreasing level of evidence. Thorough ENT and neurological clinical examination is recommended in all patients presenting with peripheral facial palsy to confirm diagnosis of Bell's palsy. MRI with gadolinium enhancement should explore the entire course of the facial nerve, if possible within the first month. ENMG should be performed to assess prognosis for recovery. In confirmed Bell's palsy, corticosteroid therapy should be implemented as early as possible (ideally within 72h) at a dose of 1mg/kg/day for 7-10 days. Antiviral therapy should be associated to steroids in patients with severe and early-onset disease and in Ramsay-Hunt syndrome. Isolated antiviral therapy is not recommended. To date, there is no evidence that surgical facial nerve decompression provides benefit.

Do farming conditions influence brominated flame retardant levels in pig and poultry products?

Brominated flame retardants (BFR) are primarily used as flame retardant additives in insulating materials. These lipophilic compounds can bioaccumulate in animal tissues, leading to human exposure via food ingestion. Although their concentration in food is not yet regulated, several of these products are recognised as persistent organic pollutants; they are thought to act as endocrine disruptors. The present study aimed to characterise the occurrence of two families of BFRs (hexabromocyclododecane (HBCDD) and polybrominated diphenyl ethers (PBDE)) in hen eggs and broiler or pig meat in relation to their rearing environments. Epidemiological studies were carried out on 60 hen egg farms (34 without an open-air range, 26 free-range), 57 broiler farms (27 without an open-air range, 30 free-range) and 42 pig farms without an open-air range in France from 2013 to 2015. For each farm, composite samples from either 12 eggs, five broiler pectoral muscles or three pig tenderloins were obtained. Eight PBDE congeners and three HBCDD stereoisomers were quantified in product fat using gas chromatography-high-resolution mass spectrometry, or high-performance liquid chromatography-tandem mass spectrometry, respectively. The frequencies of PBDE detection were 28% for eggs (median concentration 0.278 ng/g fat), 72% for broiler muscle (0.392 ng/g fat) and 49% for pig muscle (0.403 ng/g fat). At least one HBCDD stereoisomer was detected in 17% of eggs (0.526 ng/g fat), 46% of broiler muscle (0.799 ng/g fat) and 36% of pig muscle (0.616 ng/g fat). Results were similar in concentration to those obtained in French surveillance surveys from 2012 to 2016. Nevertheless, the contamination of free-range eggs and broilers was found to be more frequent than that of conventional ones, suggesting that access to an open-air range could be an additional source of exposure to BFRs for animals. However, the concentration of BFRs in all products remained generally very low. No direct relationship could be established between the occurrence of BFRs in eggs and meat and the characteristics of farm buildings (age, building materials). The potential presence of BFRs in insulating materials is not likely to constitute a significant source of animal exposure as long as the animals do not have direct access to these materials.

[Replacement of the trachea using surgical reconstruction: current state of research]. / Remplacement de trachée par reconstructions chirurgicales: état actuel de la recherche.

OBJECTIVE: To review the main studies and the recent surgical procedures in tracheal reconstruction. MATERIAL AND METHOD: The literature search was conducted using the key words "tracheal reconstruction", "grafts", and "tissue engineering" and by selecting references from the articles reviewed as well as the experience of the authors in this field. RESULTS: Surgical reconstruction for tracheal replacement without using biomaterials involves tissue grafts (auto- or allografts) and tissue engineering. Among the many procedures already described, three new techniques have emerged these past few years employing autologous mesenchymal stem-cell-derived chondrocytes, autologous cultured epithelial cells, and a matrix derived from tracheal graft; costal cartilage, recipient mucosa, and local or free flaps, and an aortic graft. These procedures have been proposed in humans with apparently good results but with a still limited follow-up. CONCLUSIONS: Tracheal reconstruction techniques have recently progressed and replacing a long segment of trachea can be envisaged for the future. Moreover, these reconstructions, in conjunction with biomaterial development, would facilitate the design and the implantation of a laryngeal prosthesis.

Cochleovestibular manifestations in Fabry disease: Importance of screening and systematic ENT evaluation.

OBJECTIVES: Fabry disease (FD) is an X-linked inherited lysosomal storage disease. It is a multisystem pathology that can include ENT disorders. The aim of the present study was to investigate the cochleovestibular manifestations of FD, in order to show the importance of screening and systematic ENT evaluation. MATERIAL AND METHODS: A single-center retrospective study included 14 male and 23 female FD patients. Hearing impairment was defined as hearing loss greater than the 90th percentile for at least one frequency. Vestibular impairment was defined by lateral semicircular canal dysfunction. Age, ongoing enzyme replacement therapy (ERT) and organic (renal, cardiac and cerebrovascular) complications were used as severity markers. RESULTS: Hearing impairment was found in 62.6% of cases, mostly at high frequencies, and was associated with age, ERT, and cardiac and cerebrovascular disorder. It affected 46.7% of asymptomatic adult patients. Vestibular impairment was found in 56% of cases, associated with age; it affected two-thirds of ERT patients, more than 60% of patients with organic complications, and 50% of asymptomatic adult patients. CONCLUSIONS: More than half of patients had ENT involvement. All FD patients should undergo early ENT screening for diagnostic, prognostic and therapeutic purposes. Systematic complete ENT follow-up with auditory and vestibular evaluation should be performed regularly, even for heterozygous women.

Influence of diet and manure management on ammonia and greenhouse gas emissions from dairy barns.

Dairy systems are a source of pollutant emissions, such as greenhouse gases (GHG) and NH3 that are associated with impacts on the environment. Gas emissions in barns are related mainly to diet intake and chemical composition, N excretion and manure management. A reduction in dietary N is known to be an effective way to reduce N excretion and the resulting NH3 emissions. However, most studies consider manure in liquid form with frequent removal from the barn. In deep litter systems, several processes can occur during the accumulation of solid manure that result in variable gas emissions. The objective of this experiment was to investigate the influence of the interaction between dietary CP (low or high) and manure management (liquid or solid) on gas emissions (NH3, N2O, CH4) at the barn level. Dietary treatments provided either low (LowN; 12% CP) or high (HighN; 18% CP) degradable protein to modify the amount of total ammonia nitrogen (TAN) excreted. The cows were housed for two 8-week periods in two mechanically ventilated rooms equipped to manage manure either in liquid (LM; slurry) or solid form (SM; deep litter). In the LM treatment, N balance was measured for 4 days. As expected, animals fed the LowN diet ingested 35% less N and excreted 65% less N in their urine, with no reduction in faecal N excretion and N secretion in milk. On the LowN diet, excretion of urea-N and NH3-N emissions were reduced regardless of the manure management. On the HighN diet, urinary urea-N excretion was three times as high, while NH3-N emissions were 3.0 and 4.5 times as high in LM and SM, respectively. Manure management strongly influenced CH4-C emissions, which were 30% higher in SM than in LM, due to the accumulation of litter. Moreover, gas emissions from solid manure increased over the accumulation period, except for NH3 on the LowN diet. Finally, our results suggest that methods used for national inventories would become more accurate by considering the variability in TAN excretion, which is the primary factor that influences NH3 emissions.

French Society of ENT (SFORL) guidelines. Indications for cochlear implantation in adults.

The authors present the guidelines of the French Society of ENT and Head and Neck Surgery (SFORL) regarding indications for cochlear implantation in adults. After a literature review by a multidisciplinary workgroup, guidelines were drawn up based on retrieved articles and group-members' experience, then read over by an independent reading group to edit the final version. Guidelines were graded A, B, C or "expert opinion" according to decreasing level of evidence. There is no upper age limit to cochlear implantation in the absence of proven dementia and if autonomy is at least partial. Bilateral implantation may be proposed if unilateral implantation fails to provide sufficiently good spatial localization, speech perception in noise and quality of life, and should be preceded by binaural hearing assessment. Rehabilitation by acoustic and electrical stimulation may be proposed when low-frequency hearing persists. Quality of life should be assessed before and after implantation.

Guidelines (short version) of the French Society of Otorhinolaryngology (SFORL) on pediatric cochlear implant indications.

OBJECTIVES: The authors present the guidelines of the French Society of Otorhinolaryngology - Head and Neck Surgery (Société française d'oto-rhino-laryngologie et de chirurgie de la face et du cou - SFORL) on the indications for cochlear implantation in children. METHODS: A multidisciplinary work group was entrusted with a review of the scientific literature on the above topic. Guidelines were drawn up, based on the articles retrieved and the group members' individual experience. They were then read over by an editorial group independent of the work group. The guidelines were graded as A, B, C or expert opinion, by decreasing level of evidence. RESULTS: The SFORL recommends that children with bilateral severe/profound hearing loss be offered bilateral cochlear implantation, with surgery before 12months of age. In sequential bilateral cochlear implantation in children with severe/profound hearing loss, it is recommended to reduce the interval between the two implants, preferably to less than 18months. The SFORL recommends encouraging children with unilateral cochlear implants to wear contralateral hearing aids when residual hearing is present, and recommends assessing perception with hearing-in-noise tests. It is recommended that the surgical technique should try to preserve the residual functional structures of the inner ear as much as possible.

Pathology of the facial nerve.

A good examination in facial nerve imaging (CT or MR imaging) depends on a good knowledge of anatomy. Two clinical situations must be considered: imaging of patients with or without facial palsy. CT and MR imaging are very useful when the symptoms are atypical or progressive: MR imaging gives very good information about the facial nerve inflammation but may also discover a schwannoma, a hemangioma, a meningioma, or a primitive or secondary cholesteatoma. In malignant tumors of the parotid gland, a study of the fallopian canal must always be performed to delineate an extension in the mastoid, tympanic, or intrameatic parts. In some rare cases, a metastasis in the temporal bone may occur, especially in the region of the geniculate ganglion. Particular attention must be paid to children with facial palsy, considering the possibility of a histiocytosis or metastasis of a neuroblastoma.

[CT imaging of the anterior ethmoidal artery: anatomic correlation]. / Imagerie tomodensitométrique de l'artère ethmoïdale antérieure: confrontation radio-anatomique.

PURPOSE: To identify the anterior ethmoidal artery (AEA) of a skull specimen on CT prior to transnasal endoscopic surgical management of anterior epistaxis. MATERIALS AND METHODS: From a medial canthotomy approach, the AEA was located and a marker placed on 9 skull specimens (18 AEA). CT with 2D reformations was then performed. The AEA were then dissected using an endoscopic anterior ethmoidectomy approach. The presence of AEA procidence was recorded. RESULTS: Correlation between CT and surgical findings allowed identification of 2 criteria predictive of AEA procidence: 1) presence of an ethmoid bulla above the AEA canal 2) AEA canal located below (not within) the ethmoid roof, anterior to the bulla. CONCLUSION: High resolution CT depiction of the AEA provides information regarding its accessibility for endoscopic ligation in patients with severe anterior epistaxis as an alternative to external ligation while demonstrating the upper limit of the anterior ethmoid.

[Case report on a nasal glioma: review of the literature]. / A propos d'un cas clinique de gliome nasal: revue de la littérature.

A nasal glioma was discovered during routine examination of the nasal cavity patency of a newborn. An excision of the lesion was done by an intranasal approach under general anaesthesia. The intranasal endoscopic approach is strongly recommended for the removal of intranasal gliomas. Angled (30 or 70 degrees) endoscopy allows visualisation of the cribriform plate which helps to rule out an intracranial extension.

Lateral semicircular canal plugging: a simple and effective surgical treatment against incapacitating Menière's disease.

OBJECTIVES: To present lateral semicircular canal plugging (LCP) technique and late results dedicated to patients with incapacitating Menière's disease. METHOD: In a prospective case-controlled baseline study, patients with unilateral incapacitating Menière's disease were treated either by LCP (n = 11) or by vestibular neurotomy (VN) (n = 11). LCP was performed by retro auricular approach, vestibular neurotomy by retro sigmoid approach. According to Menière's disease therapeutic evaluation guidelines, disability and hearing loss were assessed before and after both surgical treatments, with a 2 years followup at least. After LCP, a CT and MRI scan analyse was performed on the inner ear RESULTS: LCP was effective (A or B class) in 82% of cases (n = 9/11), 91% after VN (n = 10/11). When treatment was effective, 100% of patients regained a normal life after LCP (postoperative functional level I or 2, n = 9/9), versus 50% after VN (n = 5/10). After LCP, postoperative hearing level was unchanged in 82% of cases, n = 9/11 (73% after VN, n = 8/11), and decreased of about 30 dB in 18% (n = 2/11). There was no surgical complication. The endolymph interruption area was well visualized on MRI, allowing determining the optimal plugging area to be as far as possible from the ampulla. CONCLUSION: LCP is a simple and safe new treatment that could be very useful to control vertigo in Menière's disease. Early and late tolerance are excellent. This prospective study will go on to evaluate the potential of this innovating treatment: LCP could be recommended as an alternative to VN or chemical labyrinthectomy, except in case of drop attacks.

[Cine-MRI contribution to assess swallowing mechanism and oro-pharyngeal dysphagia]. / Etude de la déglutition et des dysphagies oro-pharyngées par ciné-IRM.

OBJECTIVE: This study aimed at evaluating the performance of Cine-MRI to assess swallowing in patients previously treated for head and neck cancer. MATERIALS AND METHODS: 10 healthy control subjects and a cohort of 10 patients with 8 partial glossectomies, 1 total laryngectomy and 1 glossolaryngectomy underwent imaging from October 2005 to February 2007. The MRI examinations were performed on a 1.5 Tesla system (Siemens Avanto), with True-Fisp sequences (TR = 170 ms, TE = 1 ms, slice thickness = 10 mm) at a rate of 8 pictures per second, during dry swallowing. RESULTS: Results are relevant for real-time spatial resolution from lips to larynx and dynamic motions analyses of tongue, velum, posterior pharyngeal wall and larynx during dry swallowing. Oro-pharyngo-laryngeal occlusion deficiency induces aspiration in case of partial glossectomy. Total laryngectomy modifies tongue, velum and pharynx landmarks. CONCLUSION: Cine-MRI i) provides functional insight from the oral cavity to the larynx, ii) gives accurate informations about impairments due to the pathology and its treatment, iii) completes others investigations like fiberoptic endoscopy or transit time, iiii) allows a precise analysis of the muscular movements involved in the deficient swallowing mechanism, in order to optimize rehabilitative strategies and results.

[Bilateral vocal cords paralysis in newborn]. / Paralysies bilatérales des cordes vocales chez le nouveau-né.

OBJECTIVE: This study aims at analyzing medical and surgical management as well as long-term follow-up of newborn (n=8) suffering from bilateral vocal cord paralysis. METHODS: This retrospective study reports information regarding pregnancy and birth history, family history, initial and delayed clinical features, treatment and follow-up of these infants. The following laryngeal procedures have been performed: Laser cordectomy (n=3), arytenoidopexy by external approach (n=2), botulinum toxin injection alone or associated with surgical treatments (n=6), enlargement laryngoplasty (n=1), endolaryngeal prostheses insertion (n=2). RESULTS: Any spontaneous recovery has been noticed. Four patients experiencing swallowing disorders required a gastrostomy in proportion to neurologic diseases and association of anomalies. Electromyograms performed were unremarkable. Botulinum toxin injected alone in laryngeal adductor muscles was not effective. The best results were observed when both arytenoidopexy and botulinum toxin injection were carried out. Bilateral cordectomies have been disappointing because of persistent vocal cord adduction. CONCLUSION: The low probability of spontaneous recovery and the drawbacks of tracheotomy encourage us to perform vocal cords adduction procedures as soon as possible.

Acute submaxillitis: Etiological data and etiological management.

OBJECTIVES: The objective of the present study was to test the hypothesis that acute submaxillitis involves salivary duct obstruction. Obstacle characteristics and treatment were analyzed. MATERIAL AND METHODS: Patients presenting with an episode of acute submaxillitis between 2009 and 2015 were retrospectively included. All underwent salivary duct imaging and/or sialendoscopy, with pathologic examination if the salivary gland was removed for etiologic diagnosis. For etiological treatment, if the causal lesion could not be treated by isolated sialendoscopy, surgery used a direct approach assisted by sialendoscope. In case of failure of these procedures, submaxillectomy was indicated. RESULTS: Twenty-nine patients were included, 28 of whom showed salivary duct abnormality. At least 1 calculus was found in 27 patients; calculi were usually single (n=20), situated in the mid-third (n=21), and large (mean 7.7mm). Ten patients showed stenosis, associated with salivary calculus in 9 cases. Twenty-five patients with salivary duct obstruction underwent sialendoscopy. Isolated sialendoscopy was used in 5 cases, and a combined approach in 13 cases. CONCLUSION: An episode of submaxillitis requires salivary duct exploration by sialendoscopy, to enable early treatment given the prevalence of associated calculi and high success rate of conservative management by sialendoscopy.

Differentiation of vestibular schwannomas from meningiomas of the internal auditory canal using perilymphatic signal evaluation on T2-weighted gradient-echo fast imaging employing steady state acquisition at 3T.

BACKGROUND: Our aim was to confirm the usefulness of the perilymphatic signal changes on T2-weighted (T2W) gradient-echo sequence to differentiate vestibular schwannomas from internal auditory canal (IAC) meningiomas, through a compartmental analysis of inner ear fluids signal intensity. METHODS: A total of 203 patients with all criteria for typical vestibular schwannoma on T1-weighted contrast-enhanced sequences were retrospectively enrolled (190 schwannomas and 13 meningiomas). All patients underwent a T2W gradient-echo steady state free precession (SSFP) acquisition at 3T. Two radiologists analysed the signal intensity of the perilymph (cistern and cochlea) and endolymph (saccule and utricle) using a region of interest-based method for obtaining ratios between the analysed structures and the cerebrospinal fluid (CSF). RESULTS: Obstructive vestibular schwannomas showed a markedly decreased perilymphatic signal in both cistern and cochlea; the cistern/CSF ratio (Ci/CSF) was 0.62. The decrease was more moderate in IAC meningiomas (Ci/CSF = 0.81). For Ci/CSF > 0.70, the tumour was more likely a meningioma, with a 92% sensitivity and 83% specificity. No endolymphatic signal changes were observed. CONCLUSION: The pronounced decrease in perilymphatic signal on a T2W SSFP sequence in obstructive vestibular schwannoma provides a new tool to differentiate schwannomas from IAC meningiomas, which may be useful to overcome the insufficiencies of morphological analysis.

[Osteointegrated cranio-facial implants: 49 patients report]. / Implants ostéointégrés cranio-faciaux. A propos de 49 patients.

OBJECTIVES: To analyze the results obtained in the total implanted population in Strasbourg, in order to assess the reliability of this technique over the long-term, especially in children and in irradiated patients. METHODS: This is a retrospective study including all the cases of cranio-facial epitheses implanted in the department of Otorhinolaryngology, head and neck surgery at the University Hospital of Strasbourg since 1992, date of the first epithesis implantation. The results (rate of osseo-integration, cutaneous complications, degree of satisfaction) are presented according to the site of implantation and the antecedent of irradiation. The results obtained in children (16 years of age and less) are specified. RESULTS: The study involved 50 patients (including 11 children), that is 51 epitheses, auricular, orbito-palpebral or naso-maxillary. 142 implants were fixed, including 49 in irradiated patients. The average rate of osseo-integration was 95.7% in the absence of irradiation, and 81.6% following irradiation, with significant differences according to the site of the implant (worse in the nasal site). Radiotherapy being a factor which reduces the rate of osseo-integration. The success rate in children was comparable to the one obtained in adults. CONCLUSION: The extraoral osseous implantology has made it possible for the facial epitheses to be considered as a forerunner in the strategies of rehabilitation in facial loss of substance, with the surgical rehabilitation techniques. It is particularly interesting in oncology, as it allows easy clinical monitoring of the operation site.