RESUMEN
Breakthrough invasive mold infections (IMIs) that occur during posaconazole or voriconazole prophylaxis are rare complications for which epidemiological data are lacking. This retrospective analysis comparing 24 microbiologically documented breakthrough with 66 nonbreakthrough IMIs shows a shift towards non-Aspergillus molds with a significantly increased proportion of rare multidrug-resistant molds.
Asunto(s)
Antifúngicos/administración & dosificación , Azoles/administración & dosificación , Hongos/efectos de los fármacos , Infecciones Fúngicas Invasoras/epidemiología , Infecciones Fúngicas Invasoras/prevención & control , Adulto , Antifúngicos/farmacología , Aspergilosis/epidemiología , Aspergilosis/prevención & control , Azoles/farmacología , Farmacorresistencia Fúngica , Femenino , Hongos/patogenicidad , Humanos , Infecciones Fúngicas Invasoras/microbiología , Infecciones Fúngicas Invasoras/mortalidad , Masculino , Pruebas de Sensibilidad Microbiana , Persona de Mediana Edad , Mucormicosis/epidemiología , Mucormicosis/prevención & control , Estudios RetrospectivosAsunto(s)
Infecciones por Coronavirus/prevención & control , Infecciones por Coronavirus/transmisión , Fallo Renal Crónico/cirugía , Trasplante de Riñón/ética , Donadores Vivos , Nefritis Lúpica/cirugía , Pandemias/prevención & control , Neumonía Viral/prevención & control , Neumonía Viral/transmisión , Adulto , Betacoronavirus , COVID-19 , Ética Médica , Femenino , Accesibilidad a los Servicios de Salud , Humanos , Riesgo , SARS-CoV-2 , Telemedicina , Obtención de Tejidos y Órganos , Resultado del Tratamiento , IncertidumbreAsunto(s)
Acanthamoeba , Encéfalo/patología , Confusión/parasitología , Cefalea/parasitología , Encefalitis Infecciosa/parasitología , Anciano , Encéfalo/diagnóstico por imagen , Resultado Fatal , Trasplante de Corazón , Humanos , Encefalitis Infecciosa/diagnóstico , Imagen por Resonancia Magnética , Masculino , Receptores de TrasplantesRESUMEN
At the start of the COVID-19 pandemic, there was an increase in the use of antibiotics for the treatment of community-acquired respiratory tract infection (CA-ARI) in patients admitted for suspected or confirmed COVID-19, raising concerns for misuse. These antibiotics are not under the usual purview of the antimicrobial stewardship unit (ASU). Serum procalcitonin, a biomarker to distinguish viral from bacterial infections, can be used to guide antibiotic recommendations in suspected lower respiratory tract infection. We modified our stewardship approach, and used a procalcitonin-guided strategy to identify "high yield" interventions for audits in patients admitted with CA-ARI. With this approach, there was an increase in the proportion of patients with antibiotics discontinued within 4 days (16.5% vs. 34.9%, p < 0.001), and the overall duration of antibiotic therapy was significantly shorter [7 (6−8) vs. 6 (3−8) days, p < 0.001]. There was a significant decrease in patients with intravenous-to-oral switch of antibiotics to "complete the course" (45.3% vs. 34.4%, p < 0.05). Of the patients who had antibiotics discontinued, none were restarted on antibiotics within 48 h, and there was no-30-day readmission or 30-day mortality attributed to respiratory infection. This study illustrates the importance of the antimicrobial stewardship during the pandemic and the need for ASU to remain attuned to prescriber's practices, and adapt accordingly to address antibiotic misuse to curb antimicrobial resistance.
RESUMEN
Early diagnosis of dengue has been made easier in recent years owing to the advancement in diagnostic technologies. The rapid non-structural protein 1 (NS1) test strip is widely used in many developed and developing regions at risk of dengue. Despite the relatively high specificity of this test, we recently encountered two cases of false-positive dengue NS1 antigen in patients with underlying hematological malignancies. We reviewed the literature for causes of false-positive dengue NS1.