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1.
Crit Rev Food Sci Nutr ; 60(13): 2265-2276, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31257904

RESUMEN

The human gut contains trillions of microorganisms with a great diversity that are associated with various health benefits. Recent studies have reported an increasing correlation between diet, gut microbiota, and human health, indicating rapid development in the field of gut health. Diet is an important factor that determines the gut microbiota composition. The gut comprises great diversities of microbes involved in immune modulation and other functions. In particular, Akkermansia muciniphila is a mucin-degrading bacterium is believed to have several health benefits in humans. Several studies have evaluated the prebiotic effects of various dietary components on A. muciniphila and their association with various ailments, such as diabetes mellitus, atherosclerosis, and cancer. Hence, this review aims to provide a plausible mechanistic basis for the interactions between dietary components, and A. muciniphila and for the therapeutic benefits of this interaction on various illnesses.


Asunto(s)
Dieta Saludable , Microbioma Gastrointestinal , Salud , Verrucomicrobia , Akkermansia , Humanos , Prebióticos
2.
Crit Rev Food Sci Nutr ; 60(17): 2914-2925, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31552753

RESUMEN

Background: Cardiovascular diseases (CVDs) commonly denote the disorders that generally occur as a result of unhealthy food habits. Heart failure, cerebrovascular illness, rheumatic heart disease are the common CVDs. The prevalence of CVD is increased considerably in recent decades upon unhealthy food habits and varied alternative factors such as diabetes, smoking and excessive use of alcohol. A change into a healthy food habit can reverse the strategy during a course of time.Objectives of the study: The objective of this review is to summarize the research findings and elaborate the relationship between the diet, gut microbiota, and CVD.Results: The dietary products containing the least saturated, trans-fat and cholesterol have the tendency to scale back the burden of CVDs, for instance, vegetables and fruits. The potential reason for the cardioprotective activity of the diet ought to be its high-unsaturated fatty acid composition and less saturated fat. Recent studies have found that gut microbiota plays a key role in mediating disease prevention. The metabolism of dietary products into varied bioactive metabolites is regulated by gut microbiota. The contributory role of gut microbiota in dietary metabolism and CVD prevention studies are increasing with promising outcomes.Conclusion: Hence, the review was proposed to reach the researchers within this field of study and share the available knowledge in gut microbiota-mediated CVD prevention. In our current review, we have updated all the research findings within the field of diet-mediated cardiovascular prevention through gut microbiota.


Asunto(s)
Enfermedades Cardiovasculares , Diabetes Mellitus , Microbioma Gastrointestinal , Microbiota , Enfermedades Cardiovasculares/prevención & control , Dieta , Humanos
3.
Neurosignals ; 20(4): 237-51, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-23172129

RESUMEN

Nuclear factor of activated T cells 5 (NFAT5) has been implicated in regulating several genes that are thought to be neuroprotective in ischemic injury. Because of the embryonic lethality of NFAT5 knockout (NFAT5(-/-)) mice, the heterozygous (NFAT5(+/-)) mice were used to study the in vivo role of NFAT5 in hypoxia/ischemia (H/I) condition. The NFAT5(+/-) mice exhibited more severe neurological deficits, larger infarct area and edema formation associated with increased aquaporin 4 expressions in the brain. Under in vitro H/I condition, increased apoptotic cell death was found in NFAT5(-/-) neurons. Moreover, SMIT, a downstream to NFAT5, was upregulated in NFAT5(+/+) neurons, while the SMIT level could not be upregulated in NFAT5(-/-) neurons under H/I condition. The elevation of reactive oxygen species generation in NFAT5(-/-) neurons under H/I condition further confirmed that NFAT5(-/-) neurons were more susceptible to oxidative stress. The present study demonstrated that activation of NFAT5 and its downstream SMIT induction is important in protecting neurons from ischemia-induced oxidative stress.


Asunto(s)
Isquemia Encefálica/genética , Isquemia Encefálica/patología , Muerte Celular/genética , Muerte Celular/fisiología , Neuronas/patología , Factores de Transcripción/deficiencia , Animales , Barrera Hematoencefálica/fisiología , Western Blotting , Células Cultivadas , Soluciones Hipertónicas , Inmunohistoquímica , Etiquetado Corte-Fin in Situ , Infarto de la Arteria Cerebral Media/patología , Ataque Isquémico Transitorio/patología , L-Lactato Deshidrogenasa/metabolismo , Luciferasas/metabolismo , Ratones , Ratones Endogámicos C57BL , Ratones Noqueados , Presión Osmótica , Especies Reactivas de Oxígeno/metabolismo , Reacción en Cadena en Tiempo Real de la Polimerasa , Simportadores/biosíntesis , Simportadores/genética , Factores de Transcripción/genética , Factores de Transcripción/fisiología
4.
Am J Physiol Cell Physiol ; 299(3): C643-53, 2010 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-20573996

RESUMEN

Hyperglycemia is an indication of poor outcome for heart attack patients, even for nondiabetic patients with stress-induced hyperglycemia. Previous studies showed that inhibition of aldose reductase, the first and rate-limiting enzyme of the polyol pathway, attenuated contractile dysfunction in diabetic animals, but the mechanism is unclear. We therefore wanted to find out whether the polyol pathway also contributes to acute hyperglycemia-induced cardiac contractile dysfunction, and determine the mechanism involved. Rat hearts were isolated and retrogradely perfused with Krebs buffer containing either normal or high concentrations of glucose for 2 h. Short exposure to high-glucose medium led to contractile dysfunction as indicated by decreased -dP/dt(max), as well as elevation in left ventricular end-diastolic pressure. Cardiomyocytes incubated in high-glucose medium showed abnormal Ca2+ signaling, most likely because of decreased activity of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) inactivated by oxidative stress. Inhibition of aldose reductase or sorbitol dehydrogenase, the second enzyme in the polyol pathway, ameliorated contractile dysfunction, attenuated oxidative stress, and normalized Ca2+ signaling and SERCA activity caused by high glucose, indicating that the polyol pathway is the major contributor to acute hyperglycemia-induced oxidative stress leading to the inactivation of SERCA and contractile dysfunction.


Asunto(s)
Aldehído Reductasa/fisiología , Corazón/fisiopatología , Hiperglucemia/metabolismo , Estrés Oxidativo , ATPasas Transportadoras de Calcio del Retículo Sarcoplásmico/metabolismo , Transducción de Señal , Enfermedad Aguda , Animales , Señalización del Calcio , Glucosa/farmacología , Glutatión/metabolismo , Hiperglucemia/fisiopatología , Técnicas In Vitro , Ácido Láctico/metabolismo , Masculino , Contracción Miocárdica , Miocardio/metabolismo , Oxidación-Reducción , Perfusión , Ácido Peroxinitroso/metabolismo , Ácido Pirúvico/metabolismo , Ratas , Ratas Sprague-Dawley , Superóxidos/metabolismo , Tirosina/metabolismo
5.
Free Radic Biol Med ; 45(5): 602-10, 2008 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-18549825

RESUMEN

Recent studies have shown that the polyol pathway is involved in ischemia-reperfusion (I/R)-induced myocardial infarction, but the mechanism is unclear. We previously found that lack of aldose reductase (AR), the first enzyme of the polyol pathway, attenuated the increase in transferrin (Tf) level in I/R brain, suggesting that AR contributes to iron-catalyzed free radical-induced damage. We therefore investigated if this mechanism occurs in I/R hearts. We found that inhibition of AR or sorbitol dehydrogenase (SDH), the second enzyme of the polyol pathway, both attenuated the I/R-mediated increases in HIF-1alpha, Tf, TfR, and intracellular iron content and reduced the I/R-induced infarct area of the heart. Further, administration of niacin, which replenishes NAD+, the cofactor for SDH, also normalized TfR and HIF-1alpha levels in I/R hearts. These results suggest that during I/R polyol pathway activity increases the cytosolic NADH/NAD+ ratio. This activates HIF-1alpha that induces the expression of TfR, which in turn increases Tf uptake and iron accumulation and exacerbates oxidative damage that increases the lipid peroxidation. This was confirmed by the fact that administration of the iron chelator deferoxamine attenuated the I/R-induced myocardial infarction.


Asunto(s)
Hierro/metabolismo , Daño por Reperfusión Miocárdica/metabolismo , Estrés Oxidativo , Polímeros/metabolismo , Transducción de Señal , Aldehído Reductasa/metabolismo , Animales , Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo , L-Iditol 2-Deshidrogenasa/metabolismo , Masculino , Malondialdehído/metabolismo , Daño por Reperfusión Miocárdica/patología , Daño por Reperfusión Miocárdica/prevención & control , Niacina/farmacología , Ratas , Ratas Sprague-Dawley , Receptores de Transferrina/metabolismo , Superóxidos/metabolismo , Transferrina/metabolismo
6.
Eur J Pharmacol ; 829: 112-120, 2018 Jun 15.
Artículo en Inglés | MEDLINE | ID: mdl-29665363

RESUMEN

Among the foremost common flavonoids within the human diet, quercetin glycosides possess neuroprotective, cardioprotective, anti-oxidative, chemopreventive, and anti-allergic properties. Isoquercetin is one such promising candidate with anti-diabetic potential. However, complete studies of its molecular action on insulin signaling pathway and carbohydrate metabolizing enzymes remain unclear. Hence, we have designed this study to accumulate the experimental evidence in support of anti-diabetic effects of isoquercetin. Male albino Wistar rats were divided into seven groups. Rats (Groups 3-7) were administered a single intraperitoneal injection of streptozotocin (STZ; 40 mg/kg b.w) to induce diabetes mellitus. As an extension, STZ rats received isoquercetin at three different doses (20, 40 and 80 mg/kg b.w), and Group 7 rats received glibenclamide (standard drug) (600 µg/kg b.w). The results showed that STZ exaggerated blood sugar, decreased insulin, altered metabolizing enzymes, and impaired the mRNA expression of insulin signaling genes and carbohydrate metabolizing enzyme genes. Supplementation with isoquercetin significantly normalized blood sugar levels, insulin and regulated the mRNA expression of insulin signaling genes and carbohydrate metabolizing enzyme genes. The results achieved with isoquercetin are similar to that of standard drug glibenclamide. The findings suggest isoquercetin could be a possible therapeutic agent for treating diabetes mellitus in the near future.


Asunto(s)
Glucemia/metabolismo , Diabetes Mellitus Experimental/complicaciones , Hiperglucemia/complicaciones , Hiperglucemia/tratamiento farmacológico , Insulina/metabolismo , Quercetina/análogos & derivados , Transducción de Señal/efectos de los fármacos , Animales , Biomarcadores/metabolismo , Regulación Enzimológica de la Expresión Génica/efectos de los fármacos , Hemoglobina Glucada/metabolismo , Glucógeno/metabolismo , Hiperglucemia/enzimología , Hiperglucemia/genética , Hipoglucemiantes/farmacología , Hipoglucemiantes/uso terapéutico , Hígado/efectos de los fármacos , Hígado/metabolismo , Masculino , Quercetina/farmacología , Quercetina/uso terapéutico , ARN Mensajero/genética , ARN Mensajero/metabolismo , Ratas , Ratas Wistar
7.
Biomed Pharmacother ; 103: 1012-1017, 2018 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-29710658

RESUMEN

Psidium guajava (PG) is a short shrub or tree cultivated in tropical and subtropical regions around the world. The leaf extract of PG (guava leaf) has been used historically to cure many ailments. However, mechanisms of action of guava leaf in treating diabetes are not fully understood. Effects and underlying mechanisms of guava leaf on gluconeogenesis and glycogenesis in hepatocytes, insulin signaling proteins, liver function markers, and lipid profile in streptozotocin (STZ) injected diabetic Wistar rats were investigated within the current study. PG was given orally at the dose of 100, 200, and 400 mg/kg b.w to diabetic rats for the period of 45 days. The results reveal that oral administration of PG (200 mg/kg b.w) has considerably raised the levels of insulin, glycogen, hexokinase, glucose-6-phosphatase dehydrogenase and significant (p < 0.05) belittled hepatic markers, gluconeogenic enzymes, and OGTT fasting blood glucose levels. OGTT has shown least statistical significance between the group 5 (200 mg/kg b.w) and group 6 and vital difference between group 5 and group 4 (400 mg/kg). PG has attenuated the triglycerides, total cholesterol, phospholipids, free fatty acid, and LDL levels and raised HDL levels. PG considerably (p < 0.05) activated IRS-1, IRS-2, Akt, p-Akt, PI3K, GLUT2, AMPK, p-AMPK, and p-ACC, which are the key effector molecules of the PI3K/Akt pathway in STZ rats. The results of our study specify that treatment with PG ameliorated glucose-metabolism and lipid profile in STZ evoked diabetic rats; the rationale ought to be the activation of PI3K/Akt, phosphorylation of AMPK pathway in liver and therefore has beneficial anti-diabetic activity.


Asunto(s)
Acetil-CoA Carboxilasa/metabolismo , Diabetes Mellitus Experimental/tratamiento farmacológico , Gluconeogénesis/efectos de los fármacos , Glucógeno/biosíntesis , Hipoglucemiantes/farmacología , Hígado/efectos de los fármacos , Extractos Vegetales/farmacología , Proteínas Quinasas/metabolismo , Psidium/química , Quinasas de la Proteína-Quinasa Activada por el AMP , Animales , Diabetes Mellitus Experimental/metabolismo , Hipoglucemiantes/aislamiento & purificación , Hipoglucemiantes/uso terapéutico , Hígado/metabolismo , Masculino , Extractos Vegetales/aislamiento & purificación , Extractos Vegetales/uso terapéutico , Hojas de la Planta/química , Ratas Wistar , Transducción de Señal , Estreptozocina
8.
Biomed Res Int ; 2018: 4601649, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-29670899

RESUMEN

Traditional Chinese medication has been utilized by Chinese medical practitioners to treat the varied symptoms of diabetes mellitus (DM). Notably, guava leaf has been used to treat diabetes in Asia. Our present study has been designed to analyze the action of guava leaf extract (GLE) at the molecular level in treating DM. A low dose of streptozotocin (STZ) was used to induce experimental diabetes in animals. Rats were treated with GLE at different concentrations (100, 200, and 400 mg/kg b.w.). The standard drug glibenclamide (GB) (600 µg/kg b.w.) was used for comparison. The diabetic rats showed a reduced level of insulin, accompanied by exaggerated levels of blood glucose, lipid peroxidation product, and augmented expressions of inflammatory cytokines, and showed reduced levels of antioxidants compared to the control rats. Supplementation with GLE counteracted the consequences of STZ. It suppresses the oxidative stress and inhibits the state of inflammation and the results are almost similar to that of standard drug group (GB group 5). Our present research, therefore, provides useful data concerning guava leaf extract by a thorough assessment in diabetes management. Being a natural product, additional analysis on GLE can shed light on finding effective phytochemicals within the field of diabetes mellitus.


Asunto(s)
Diabetes Mellitus Experimental/tratamiento farmacológico , Hiperglucemia/tratamiento farmacológico , Inflamación/tratamiento farmacológico , Células Secretoras de Insulina/patología , FN-kappa B/metabolismo , Estrés Oxidativo , Extractos Vegetales/uso terapéutico , Psidium/química , Animales , Antioxidantes/metabolismo , Biomarcadores/metabolismo , Glucemia/metabolismo , Muerte Celular/efectos de los fármacos , Cromatografía Líquida de Alta Presión , Diabetes Mellitus Experimental/patología , Flavonoides/análisis , Hiperglucemia/patología , Inflamación/patología , Insulina/sangre , Células Secretoras de Insulina/efectos de los fármacos , Células Secretoras de Insulina/metabolismo , Peroxidación de Lípido/efectos de los fármacos , Masculino , Especificidad de Órganos , Estrés Oxidativo/efectos de los fármacos , Fenoles/análisis , Extractos Vegetales/farmacología , Hojas de la Planta/química , Ratas Wistar , Transducción de Señal/efectos de los fármacos , Solventes , Estreptozocina
9.
J Nutr Biochem ; 61: 101-110, 2018 11.
Artículo en Inglés | MEDLINE | ID: mdl-30196242

RESUMEN

The ß-glucans are the glucose polymers present in the cells walls of yeast, fungi and cereals. ß-Glucans are the major compositions of various nutritional diets such as oats, barley, seaweeds and mushrooms. Various biological activities of ß-glucans have been reported such as anticancer, antidiabetic, anti-inflammatory and immune-modulating effects. The importance of ß-glucans in food processing industries such as bread preparation, yogurt and pasta have been well elucidated. In recent findings on food science research gut microbiota plays a significant role and vastly studied for its intermediate role in regulating health. Several reports have suggested that ß-glucans should have a significant impact on the gut microbiota changes and in turn on human health. The review was aimed to accumulate the evidence on types of ß-glucans, their functional properties and the mechanism by how the ß-glucans regulate the gut microbiota and human health. The various in vitro, in vivo and clinical studies, have been summarized, in particular, the changes happening upon the ß-glucans supplementation on the gut microbiota. Overall, this review updates the recent studies on ß-glucans and gut microbiota and also inputs the demanding questions to be addressed in ß-glucans-microbiota research in the future.


Asunto(s)
Microbioma Gastrointestinal/fisiología , beta-Glucanos/química , beta-Glucanos/farmacología , Animales , Anticarcinógenos/química , Anticarcinógenos/farmacología , Cardiotónicos/química , Cardiotónicos/farmacología , Neoplasias del Colon/microbiología , Neoplasias del Colon/prevención & control , Fibras de la Dieta/farmacología , Microbioma Gastrointestinal/efectos de los fármacos , Humanos , Factores Inmunológicos/química , Factores Inmunológicos/farmacología
10.
Sci China Life Sci ; 58(6): 521-30, 2015 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-25985753

RESUMEN

Ischemia occurs in diabetic retinopathy with neuronal loss, edema, glial cell reactivity and oxidative stress. Epacs, consisting of Epac1 and Epac2, are cAMP mediators playing important roles in maintenance of endothelial barrier and neuronal functions. To investigate the roles of Epacs in the pathogenesis of ischemic retinopathy, transient middle cerebral artery occlusion (tMCAO) was performed on Epac1-deficient (Epac1 (-/-)) mice, Epac2-deficient (Epac2 (-/-)) mice, and their wild type counterparts (Epac1 (+/+) and Epac2 (+/+)). Two-hour occlusion and 22-hour reperfusion were conducted to induce ischemia/reperfusion injury to the retina. After tMCAO, the contralateral retinae displayed similar morphology between different genotypes. Neuronal loss, retinal edema and increase in immunoreactivity for aquaporin 4 (AQP4), glial fibrillary acidic protein (GFAP), peroxiredoxin 6 (Prx6) were observed in ipsilateral retinae. Epac2 (-/-) ipsilateral retinae showed more neuronal loss in retinal ganglion cell layer, increased retinal thickness and stronger immunostaining of AQP4, GFAP, and Prx6 than those of Epac2 (+/+). However, Epac1 (-/-) ipsilateral retinae displayed similar pathology as those in Epac1 (+/+) mice. Our observations suggest that Epac2-deficiency led to more severe ischemic retinopathy after retinal ischemia/reperfusion injury.


Asunto(s)
Factores de Intercambio de Guanina Nucleótido/genética , Infarto de la Arteria Cerebral Media/metabolismo , Isquemia/metabolismo , Neuroglía/patología , Estrés Oxidativo , Retina/patología , Enfermedades de la Retina/metabolismo , Animales , Acuaporina 4/genética , Femenino , Genotipo , Proteína Ácida Fibrilar de la Glía , Factores de Intercambio de Guanina Nucleótido/deficiencia , Factores de Intercambio de Guanina Nucleótido/fisiología , Inmunohistoquímica , Masculino , Ratones , Ratones Endogámicos C57BL , Ratones Transgénicos , Proteínas del Tejido Nervioso/metabolismo , Peroxiredoxina VI/genética , Daño por Reperfusión/metabolismo , Retina/metabolismo
11.
PLoS One ; 6(11): e26994, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-22096514

RESUMEN

Endothelin-1 (ET-1) is a potent vasoconstrictor involved in the regulation of vascular tone and implicated in hypertension. However, the role of small blood vessels endothelial ET-1 in hypertension remains unclear. The present study investigated the effect of chronic over-expression of endothelial ET-1 on arterial blood pressure and vascular reactivity using transgenic mice approach. Transgenic mice (TET-1) with endothelial ET-1 over-expression showed increased in ET-1 level in the endothelial cells of small pulmonary blood vessels. Although TET-1 mice appeared normal, they developed mild hypertension which was normalized by the ET(A) receptor (BQ123) but not by ET(B) receptor (BQ788) antagonist. Tail-cuff measurements showed a significant elevation of systolic and mean blood pressure in conscious TET-1 mice. The mice also exhibited left ventricular hypertrophy and left axis deviation in electrocardiogram, suggesting an increased peripheral resistance. The ionic concentrations in the urine and serum were normal in 8-week old TET-1 mice, indicating that the systemic hypertension was independent of renal function, although, higher serum urea levels suggested the occurrence of kidney dysfunction. The vascular reactivity of the aorta and the mesenteric artery was altered in the TET-1 mice indicating that chronic endothelial ET-1 up-regulation leads to vascular tone imbalance in both conduit and resistance arteries. These findings provide evidence for the role of spatial expression of ET-1 in the endothelium contributing to mild hypertension was mediated by ET(A) receptors. The results also suggest that chronic endothelial ET-1 over-expression affects both cardiac and vascular functions, which, at least in part, causes blood pressure elevation.


Asunto(s)
Células Endoteliales/metabolismo , Endotelina-1/metabolismo , Hipertensión/metabolismo , Animales , Arterias/metabolismo , Arterias/fisiología , Presión Sanguínea/fisiología , Electrocardiografía , Endotelina-1/genética , Corazón/fisiología , Hipertensión/genética , Hibridación in Situ , Técnicas In Vitro , Pulmón/metabolismo , Masculino , Ratones , Ratones Transgénicos , Tamaño de los Órganos
12.
J Cereb Blood Flow Metab ; 29(12): 1891-902, 2009 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-19707218

RESUMEN

Transgenic mice overexpressing endothelin-1 (ET-1) in astrocytes (GET-1) displayed more severe brain edema and neurologic dysfunction after experimental ischemic stroke. However, it was not clear whether astrocytic ET-1 contributed to cytotoxic or vasogenic edema associated with stroke. In this study, the role of astrocytic ET-1 in cytotoxic edema and brain injury was investigated. Upon acute water intoxication, the GET-1 mice had a lower survival rate and more severe neurologic deficits. Such an exacerbated condition in the GET-1 mice may be a result of a significant increase in cerebral water content and increased expression of the water channel protein, aquaporin 4 (AQP-4). The GET-1 mice treated with OPC-31260, a nonpeptide arginine vasopressin V(2) receptor antagonist, were alleviated from the cerebral water accumulation and neurologic deficit during the early time period after water intoxication. In addition, a significant reduction of AQP-4 expression was observed in astrocytic end-feet AQP-4 in the hippocampus of the GET-1 mice treated with OPC-31260. Therefore, ET-1-induced AQP-4 expression and cerebral water accumulation are the key factors in brain edema associated with acute water intoxication. The V(2) receptor antagonist, OPC-31260, may be one of the effective drugs for the early treatment of ET-1-induced cytotoxic edema and brain injury.


Asunto(s)
Astrocitos/metabolismo , Edema Encefálico/fisiopatología , Endotelina-1/metabolismo , Regulación hacia Arriba , Animales , Antagonistas de los Receptores de Hormonas Antidiuréticas , Acuaporina 4/genética , Acuaporina 4/metabolismo , Benzazepinas/uso terapéutico , Encéfalo/fisiopatología , Edema Encefálico/inducido químicamente , Endotelina-1/genética , Proteína Ácida Fibrilar de la Glía/genética , Proteína Ácida Fibrilar de la Glía/metabolismo , Ratones , Ratones Transgénicos , Agua/metabolismo , Intoxicación por Agua/inducido químicamente , Intoxicación por Agua/tratamiento farmacológico
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