RESUMEN
A histological mapping procedure was used to study 32 stomachs bearing small cancers and 23 stomachs bearing ulcers. Over 80 per cent of gastric cancers and peptic ulcers occurred within 2 cm of both a mucosal junction and the lesser curvature. They showed slight differences in their longitudinal relationship to the pyloric junction. There were differential characteristics between the groups of cancers arising at each of the three mucosal junctions. Cancers at the pylorus and cardia were more common in males (M:F--2.6:1) and were predominantly well differentiated, whereas those from the intermediate zone were more common in females (M:F--1:1.8) with a relatively higher proportion of undifferentiated cancers. These and other features suggest that gastric cancers should be subdivided according to the junction of origin.
Asunto(s)
Neoplasias Gástricas/patología , Úlcera Gástrica/patología , Estómago/patología , Femenino , Mucosa Gástrica/patología , Humanos , MasculinoRESUMEN
Of 31 cases of haemorrhage from oesophageal varices treated by sclerotherapy eight came to necropsy. The oesophagus and proximal stomach were studied by means of a serial block technique and the histopathological findings in each case were recorded on two full-scale maps: one representing superficial tissues including the submucosa and the other the deeper tissues. The patterns of thrombosis, ulceration, necrosis, and fibrosis were studied in relation to the time interval since injection. Thrombosis and tissue necrosis were present within 24 hours of sclerotherapy, ulceration after seven days, and fibrosis after a month. Fibrosis was sometimes associated with stricture formation, which readily responded to dilatation. Patients with fibrosis had a reduced incidence of rebleeding.
Asunto(s)
Várices Esofágicas y Gástricas/terapia , Esófago/patología , Alcoholes Grasos/uso terapéutico , Tetradecil Sulfato de Sodio/uso terapéutico , Enfermedades del Esófago/inducido químicamente , Enfermedades del Esófago/patología , Hemorragia Gastrointestinal/terapia , Humanos , Necrosis , Tetradecil Sulfato de Sodio/efectos adversos , Trombosis/patología , Úlcera/inducido químicamente , Úlcera/patologíaRESUMEN
Before the introduction of endoscopy, four out of 720 cases of gastric cancer were diagnosed before the cancer had breached the muscularis propia, an incidence of 0.5%. Using endoscopy and endoscopic biopsy, 10 out of 101 cases of gastric cancer were diagnosed at this "early" stage, an incidence of 10%. Their clinical, morphological, and histological characteristics are compared with those of Japanese "early gastric cancers" and reveal a remarkable similarity. The results of this study suggest that a higher proportion of British gastric cancers could be diagnosed at an "early" stage by more intensive investigation of dyspeptic patients using up to date radiological techniques, fibreoptic endoscopy, and endoscopic biopsy.