Evaluation of the effect of gluten-free diet and Mediterranean diet on autoimmune system in patients with Hashimoto's thyroiditis.

Hashimoto's thyroiditis is an autoimmune disease in which thyroid cells are attacked through cell-and antibody-mediated immune processes. A gluten-free diet reduces antibody concentration and regulates thyroid autoimmunization. Mediterranean diet reduces oxidative stress. This study evaluates the short-term effects of Mediterranean, gluten-free, and Mediterranean gluten-free dietary patterns on thyroid function and autoantibody levels of patients. The 40 patients with Hashimoto's thyroiditis included in the study were randomly divided into four groups (defined as gluten-free, Mediterranean, Mediterranean gluten-free, and controls) for 12 weeks. Thyroid function tests, autoantibody levels, and food consumption were recorded at the beginning and end of the study. There was no statistically significant difference in TSH levels of the groups before the intervention, but a statistically significant difference was found afterward (p < 0.05). Free T3 hormone levels showed a statistically significant difference across the groups before and after the intervention (p < 0.05). Free T3 hormone levels increased significantly in all intervention groups after the intervention, with the highest increase in the Mediterranean group (p < 0.05). In the intervention groups, anti-TPO and anti-Tg levels decreased after the intervention; however, this difference was not significant across groups (p > 0.05). In addition, body weight, body mass index, waist and hip circumference averages decreased significantly in all intervention groups compared with controls (p < 0.05). The study achieved an increase in Free T3 hormone levels in the intervention groups. The most marked difference was seen in the Mediterranean gluten-free diet model, which may be due to the anti-inflammatory effect of both Mediterranean and gluten-free diets and the loss of body weight as a result of the intervention.

Results from phase 1 of the MANIFEST clinical trial to evaluate the safety and tolerability of pelabresib in patients with myeloid malignancies.

Pelabresib (CPI-0610), a BET protein inhibitor, is in clinical development for hematologic malignancies, given its ability to target NF-κB gene expression. The MANIFEST phase 1 study assessed pelabresib in patients with acute leukemia, high-risk myelodysplastic (MDS) syndrome, or MDS/myeloproliferative neoplasms (MDS/MPNs) (NCT02158858). Forty-four patients received pelabresib orally once daily (QD) at various doses (24-400 mg capsule or 225-275 mg tablet) on cycles of 14 d on and 7 d off. The most frequent drug-related adverse events were nausea, decreased appetite, and fatigue. The maximum tolerated dose (MTD) was 225 mg tablet QD. One patient with chronic myelomonocytic leukemia (CMML) showed partial remission. In total, 25.8% of acute myeloid leukemia (AML) patients and 38.5% of high-risk MDS patients had stable disease. One AML patient and one CMML patient showed peripheral hematologic response. The favorable safety profile supports the ongoing pivotal study of pelabresib in patients with myelofibrosis using the recommended phase 2 dose of 125 mg tablet QD.CLINICAL TRIAL REGISTRATION: NCT02158858.

Can Dietary Fiber Knowledge Level Be a Determinant of Dietary Fiber Intake in Adolescents? Turkey Example / ¿Puede el nivel de conocimiento de la fibra dietética ser un factor determinante de la ingesta de fibra dietética en los adolescentes? Ejemplo de Turquía

Objective: This study aims to determine the relationshipbetween dietary fiber knowledge level, nutritional status, anddietary fiber in adolescents. Methods: This research was carried out on 276 adolescents between the ages of 14-17 who studied at the highschool level in İnegöl between November 2018 and May 2019and who voluntarily agreed to participate in the research. Athreestage questionnaire was applied to the participants, andtheir anthropometric measurements were taken. A dietaryfiber knowledge level scale (KADF) was used to determine thelevel of diet fiber knowledge. Three days of dietary recordwas taken to determine the nutritional status. Results: The mean percentage of the adolescents abouttheir level of knowledge about dietary fiber sources (SDF) is41.0 ± 16.1 (min: 0-max: 100), while the mean percentageof their knowledge about the effects of dietary fiber on health(DFPH) is 63.5 ± 18.1 (min: 0-max: 100). The average of thetotal score percentage was determined as 52.2 ± 12.3 (min:18.8-max: 100). Although participants have a high level ofknowledge about the health effects of dietary fiber, theirawareness of dietary fiber sources is low. The percentage ofDFPH scores of female and male adolescents studying in science high school is significantly higher compared to individuals studying in college. There was no statistically significantdifference between dietary fiber information levels of adolescents and daily diet, energy, nutrient consumption, and vitamin mineral intake (p> 0.05). There was no statistically significant difference in dietary fiber information levels and dailydietary fiber consumption of adolescents (p> 0.05). Conclusion: This is since the level of knowledge is a necessary but not sufficient factor in food selection. As a result,more studies are needed to examine the relationship between dietary fiber knowledge level and dietary fiber intakein adolescents.(AU)

Este estudio tiene como objetivo determinar la relación entre el nivel de conocimiento de la fibra dietética, el estado nutricional y la fibra dietética en adolescentes. Esta investigación se llevó a cabo en 276 adolescentes de 14 a 17 años que estudiaron el nivel secundario en İnegöl entre noviembre de 2018 y mayo de 2019 y que voluntariamente aceptaron participar en la investigación. Se utilizó una escala de nivel de conocimiento de fibra dietética (KADF) para determinar el nivel de conocimiento de fibra dietética. Se tomó registro de tres días de consumo de alimentos para determinar el estado nutricional. El porcentaje medio de los adolescentes sobre su nivel de conocimiento sobre las fuentes de fibra dietética (SDF) es de 41,0 ± 16,1 (min: 0-max: 100), mientras que el porcentaje medio de su conocimiento sobre los efectos de la fibra dietética en la salud (DFPH) es 63,5 ± 18,1 (mín: 0-máx: 100). El promedio del porcentaje de puntuación total se determinó como 52,2 ± 12,3 (mín: 18,8-máx: 100). El porcentaje de puntajes DFPH de adolescentes mujeres y hombres que estudian en la escuela secundaria de ciencias es significativamente mayor en comparación con las personas que estudian en la universidad. No hubo diferencia estadísticamente significativa entre los niveles de información de fibra dietética de los adolescentes y la dieta diaria, la energía, el consumo de nutrientes y la ingesta de vitaminas y minerales (p> 0,05). No hubo diferencia estadísticamente significativa en los niveles de información de fibra dietética y el consumo diario de fibra dietética de los adolescentes (p> 0,05). Como resultado, se necesitan más estudios para examinar la relación entre el nivel de conocimiento de fibra dietética y la ingesta de fibra dietética en adolescentes.(AU)

Reliability and Validation of the Children’s Eating AttitudesTest among 10- to 14-Year-Old School Children in Turkey / Confiabilidad y Validación de la Prueba de Actitudes Alimentarias de los Niños entre Escolares de 10 a 14 Años en Turquía

Introduction: Eating disorders (ED) onset occurs com-monly during adolescence and this is a very critical period oflife in the context of developmental perspectives because ad-equate nutrition is necessary for optimal growth and devel-opment. Nutritional disorders can be harmful and cause ex-treme and potentially permanent physical and psychologicalconsequences. Therefore, defining the eating disorder in itsearly stages is important. Objective: The goal of this study was to translate theChildren’s Eating Attitude Test (CHEAT) into Turkish and es-tablish its validity and reliability among Turkish schoolchil-dren. Methods: The study was conducted on students from twoprivate and two public primary schools. After delivering invi-tations to suitable classes, informed consents that had beenwritten by participants and parents were collected. Results: The research comprised 352 children betweenthe ages of 10 and 14, including 222 females and 130 boys.Minimum factor loading is 0.597 and total percentage of ex-plained variance is 58.04 The CFA supported these findings,since the 15-item scale had a greater goodness-of-fit and ex-ploratory component analysis generated four factors. Conclusion: Analysis of data showed that the ChEAT scaleis a valid and reliable measurement tool available in Turkey. Itis thought that the ChEAT scale will contribute to studies oneating disorders in children aged between 10-14 years.(AU)