Detalles de la búsqueda
1.
Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death.
Diabetologia
; 66(8): 1544-1556, 2023 08.
Artículo
Inglés
| MEDLINE | ID: mdl-36988639
2.
The T1D-associated lncRNA Lnc13 modulates human pancreatic ß cell inflammation by allele-specific stabilization of STAT1 mRNA.
Proc Natl Acad Sci U S A
; 117(16): 9022-9031, 2020 04 21.
Artículo
Inglés
| MEDLINE | ID: mdl-32284404
3.
IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells.
Diabetologia
; 61(3): 636-640, 2018 03.
Artículo
Inglés
| MEDLINE | ID: mdl-29305625
4.
GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim.
PLoS Genet
; 9(5): e1003532, 2013 May.
Artículo
Inglés
| MEDLINE | ID: mdl-23737756
5.
The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.
PLoS Genet
; 8(3): e1002552, 2012.
Artículo
Inglés
| MEDLINE | ID: mdl-22412385
6.
Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.
PLoS Pathog
; 7(9): e1002267, 2011 Sep.
Artículo
Inglés
| MEDLINE | ID: mdl-21977009
7.
Interferon-α promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic ß-cells.
bioRxiv
; 2023 Sep 17.
Artículo
Inglés
| MEDLINE | ID: mdl-37745505
8.
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation.
J Biol Chem
; 286(2): 929-41, 2011 Jan 14.
Artículo
Inglés
| MEDLINE | ID: mdl-20980260
9.
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA.
Hum Mol Genet
; 19(1): 135-46, 2010 Jan 01.
Artículo
Inglés
| MEDLINE | ID: mdl-19825843
10.
Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic ß Cells.
Noncoding RNA
; 8(5)2022 Oct 12.
Artículo
Inglés
| MEDLINE | ID: mdl-36287121
11.
A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes.
Front Immunol
; 12: 748679, 2021.
Artículo
Inglés
| MEDLINE | ID: mdl-34721418
12.
CD8+ T Cells Variably Recognize Native Versus Citrullinated GRP78 Epitopes in Type 1 Diabetes.
Diabetes
; 70(12): 2879-2891, 2021 12.
Artículo
Inglés
| MEDLINE | ID: mdl-34561224
13.
Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes.
Front Endocrinol (Lausanne)
; 11: 568446, 2020.
Artículo
Inglés
| MEDLINE | ID: mdl-33042023
14.
SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic ß-Cells and in the Human Pancreas Microvasculature.
Front Endocrinol (Lausanne)
; 11: 596898, 2020.
Artículo
Inglés
| MEDLINE | ID: mdl-33281748
15.
Peptides Derived From Insulin Granule Proteins Are Targeted by CD8+ T Cells Across MHC Class I Restrictions in Humans and NOD Mice.
Diabetes
; 69(12): 2678-2690, 2020 12.
Artículo
Inglés
| MEDLINE | ID: mdl-32928873
16.
Persistent or Transient Human ß Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.
Cell Rep
; 33(9): 108466, 2020 12 01.
Artículo
Inglés
| MEDLINE | ID: mdl-33264613
17.
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells.
Nat Commun
; 11(1): 2584, 2020 05 22.
Artículo
Inglés
| MEDLINE | ID: mdl-32444635
18.
Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic ß Cells.
J Innate Immun
; 11(4): 375-390, 2019.
Artículo
Inglés
| MEDLINE | ID: mdl-30799417
19.
The impact of proinflammatory cytokines on the ß-cell regulatory landscape provides insights into the genetics of type 1 diabetes.
Nat Genet
; 51(11): 1588-1595, 2019 11.
Artículo
Inglés
| MEDLINE | ID: mdl-31676868
20.
PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction.
EBioMedicine
; 36: 367-375, 2018 Oct.
Artículo
Inglés
| MEDLINE | ID: mdl-30269996