RESUMEN
In tests conducted on 220 rats with transplantable sarcoma M-1 and intact animals acute toxicity, antineoplastic effect and the action on the blood system of tomizine, a new neoplastic drug of the group of the folic acid antagonists, were studied. Investigation involved a single intraperitoneal injection of the drug in DL50/30 and MTD. The compound is shown to exert an inhibiting action on the development of sarcoma M-1 and lengthens the survival of the tumour-stricken animals, without producing any pronounced myelotoxic effect. The disclosed shifts on the level of the periphedal blood and marrow were short-lived and concerned mainly the erythroid germ cells.
Asunto(s)
Anemia Aplásica/inducido químicamente , Antagonistas del Ácido Fólico/toxicidad , Sarcoma Experimental/tratamiento farmacológico , Tiazinas/toxicidad , Anemia Aplásica/patología , Animales , Médula Ósea/patología , Antagonistas del Ácido Fólico/efectos adversos , Ratas , Factores de TiempoRESUMEN
The autoradiographic method was used to study proliferative activity of cells of a myeloid and erythroid compartments of the bone marrow of intact and irradiated (a single exposure of 10 Gy) rats. The proliferative activity and differentiation rate of cells decreased at early times after irradiation. It was shown that giant neutrophils had heavy tracer nuclei, were formed from myeloblasts, being at the most active phase of the S stage at the time of irradiation, and had a very low differentiation rate.
Asunto(s)
Células Madre Hematopoyéticas/efectos de la radiación , Traumatismos Experimentales por Radiación/patología , Enfermedad Aguda , Animales , Autorradiografía , Diferenciación Celular/efectos de la radiación , División Celular/efectos de la radiación , Células Madre Hematopoyéticas/patología , Masculino , RatasRESUMEN
Experiments on 110 white noninbred tumor-free rats were made to explore the myelotoxic action of a new antineoplastic drug spirobramine. A single (200 mg/kg) intravenous injection and a course of drug treatment (40 mg/kg 5 times every other day) produced monotypic changes in the peripheral blood and bone marrow hemopoiesis, primarily marked by inhibition of erythroid, eosinophilic and thrombocytic myeloid fibers followed by the development of moderate anemia, thrombocytopenia and aneosinophilia in the peripheral blood. A single injection of spirabramine in an MTD produced more pronounced changes in the blood than injection of the drug in divided doses.