Single-incision Laparoscopic Intragastric Surgery for a Pancreatic Pseudocyst.

Single-incision Laparoscopic Surgery is an emerging laparoscopic technique that aims for a minimal invasive approach. Several cases and series have been reported in literature for a wide variety of pathologies, such as appendectomy, cholecystectomy, bariatric procedures and colonic surgery. We report the case of an intragastric cystogastrostomy performed by SILS in a patient with a symptomatic pseudocyst of the pancreas. With this case we would like to demonstrate the feasibility and safety of the procedure.

Surgical management of gastrointestinal stromal tumours: a single centre experience during the past 17 years.

BACKGROUND: Gastrointestinal stromal tumour (GIST) is a rare tumour that can arise anywhere within the gastrointestinal tract. OBJECTIVES: Our objective was to present our experience managing this rare tumour of the gastrointestinal tract. We reviewed the clinico-pathological and morphological features, our experience with surgical treatment, and the outcome GIST in our centre. PATIENTS AND METHODS: The current retrospective analysis included 64 patients with GIST observed between February 1995 and September 2012. RESULTS: There were 39 males and 25 females. The mean age was 63.2 (range 36-83). The GISTs were located in the stomach in the majority of patients (60 patients, 94.0%). The tumour was asymptomatic in 14 (21.9%) patients. The tumour size varied from 0.4 to 25 cm with a mean size of 7.9 cm. Five patients showed peritoneal or liver metastasis at diagnosis. All patients had surgery. Five patients had a R2 resection and in one patient the resection-free margin was uncertain. In our cohort we had 5 patients with metastasis at diagnosis who received adjuvant imatinib. Four patients developed metastasis in the follow-up period. Three patients died due to GIST, three other patients died due to other disease. CONCLUSIONS: Gastric GIST were more common than GIST at other locations. Surgical treatment was the main therapeutic option. Tyosine kinase receptor inhibitors was used as a first line treatment in patients with metastatic GISTs or in patients with recurrence of the disease.

Laparoscopic resection of gastric gastrointestinal stromal tumors (GIST) is safe and effective, irrespective of tumor size.

BACKGROUND: Feasibility and long-term safety of laparoscopic removal of gastric gastrointestinal stromal tumors (GISTs) of the stomach is well established for lesions smaller than 2 cm. Our specific aim was to explore whether laparoscopic treatment is equally applicable for gastric GISTs larger than 2 cm. METHODS: Between 1997 and 2010, 31 consecutive patients presenting with a primary gastric GIST were scheduled for laparoscopic resection, irrespective of tumor size. Prerequisites for laparoscopic approach were the absence of metastases and the presence of a well-defined tumor on CT scanning without involvement of adjacent organs, the esophagogastric junction, or the pylorus of the stomach. Data were retrieved retrospectively from a prospectively collected database, including information on patient demographics, surgical procedure, complications, hospital stay, and recurrence. Diagnosis of GIST was based on microscopic analysis, including immunohistochemistry with a panel of antibodies: CD117, CD34, DOG1, S100, desmin, and smooth muscle actin. RESULTS: All 31 laparoscopic resections were carried out successfully. The most common symptoms were melena, anemia, and abdominal pain. In one case we performed a laparoscopic approach for a GIST with acute bleeding. Tumor size was smaller than 2 cm in 5 patients and larger than 2 cm in 26 patients. The median tumor size was 4.4 cm (range = 0.4-11.0 cm). Median blood loss was identical in both groups (20 ml), but duration of operation (60 vs. 103 min) and duration of hospital stay (6 vs. 8 days) were lower when tumor size was less than 2 cm. Only one patient (with tumor size <2 cm) experienced a postoperative hemorrhage. After a median follow-up of 52 months, there were no recurrences or metastases. CONCLUSION: The low morbidity rates and the long-term disease-free interval of 100% observed in our cohort indicate that laparoscopic resection is safe and effective in treating gastric GISTs, even for tumors larger than 2 cm.

Laparoscopic repair of diaphragmatic Morgagni hernia.

A novel case of laparoscopic repair of a diaphragmatic hernia through the foramen of Morgagni in a 5-year-old boy is reported. The patient had a prompt and complete recovery, with no evidence of recurrence noted at 1 year after surgery. Laparoscopic repair is considered to be a suitable and safe procedure for the treatment of Morgagni hernia.

GIST of stomach: an update on surgery.

Gastrointestinal stromal tumors (GISTs) are rare tumors and represent approximately 0.1-3% of all gastrointestinal cancers. They can occur anywhere in the gastrointestinal tract, but the stomach is the most affected area (60-70%). Traditionally, gastric GIST resection has been carried out by means of open surgery, but more recently, less invasive methods have been described. The fact that routine lymphadenectomy are not associated with an improved oncologic outcome (as adult GIST do not metastasize to lymph nodes) advocates in favor of laparoscopic treatment of GISTs. The laparoscopic approach mimics the open approach and allows full-thickness resection of the stomach wall containing the tumor with negative margins. Compared to open resection, laparoscopic resection of gastric GIST is associated with a shorter operation time, a shorter hospital stay, and a lower recurrence rate. For the treatment of gastric GISTs located at less reachable sites laparoscopic resection cannot be applied easily and single incision laparoscopic surgery (SILS) can offer an advantage in these cases. It allows direct visualization of the lesion and better control of the surgical margin. This new technique may also provide evolution towards the use of SILS device for other intragastric procedures. Since the discovery of highly active targeted therapies, resulting in a drastic improvement of the long-term outcome of GIST, this disease has a better prognosis than before 2000.

Removal of Eroded Gastric Bands Using a Transgastric SILS Device.

Background. Laparoscopic adjustable gastric banding (LAGB) is a popular method for the treatment of morbid obesity. One of the most feared complications is gastric band erosion which occurs with a reported incidence of 0.3 to 14%. Intragastric migrated bands are best managed by endoscopic removal. Recent case studies reported successful endoscopic removal of intragastric migrated bands, but it is not always possible. We report our first experience with a transgastric removal of eroded bands using a Single Incision Laparoscopic Surgery (SILS) device. Methods. A patient who underwent gastric banding in the past (2007) presented with symptoms of epigastric pain and weight gain. Preoperative gastroscopy revealed stomach wall erosion with the gastric band partially (2/3) migrated into the gastric lumen. Attempts to remove the band by endoscopy were not successful. A laparoscopy was performed and multiple adhesions with evidence of inflammation was seen in the upper abdomen around the band. A SILS port was inserted through a 2 cm incision in the left hypochondrium with the internal ring of the port placed into the stomach through a small anterior gastrotomy. The band was cut in the stomach and removed. The anterior gastrotomy was closed. We had a perfect intragastric view of the gastric banding. Results. There were no intra- or postoperative complications. The patient was discharged on the fifth postoperative day on a gastric adapted diet. Conclusion. Removal of a gastric band after gastric erosion by SILS is feasible, safe, and effective. This is the first reported case of transgastric removal of eroded bands using an SILS device.

Gastrointestinal stromal tumor of the stomach: progresses in diagnosis and treatment.

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal smooth muscle neoplasms that can arise anywhere within the gastrointestinal tract. Approximately 60-70% are located in the stomach. Once considered variants of smooth muscle tumors, they are now understood as originating from the interstitial cells of Cajal or their stem cell precursors. The majority of GISTs (approximately 95%) express the CD117 antigen (KIT), a proto-oncogene product ; 85-95% of these neoplasms have mutations in the c-KIT gene; only 5-7% has mutations in platelet-derived-growth factor a (PDGFRa). GISTs can be asymptomatic and incidentally found during examination for other pathologies or at autopsy. The most common symptoms of gastric GIST are abdominal pain and bleeding. Diagnostic work up consists of endoscopy with ultrasonography and cross-sectional imaging studies (computed tomography and/or magnetic resonance imaging). Surgery remains the first-line treatment for localized gastric GISTs. Both open and laparoscopic operations have been shown to reduce recurrence rates and improve long-term survival. The use of small-molecule selective tyrosine kinase receptor inhibitors has revolutionized the treatment of advanced GISTs.

Dysphagia after colon interposition graft for esophageal carcinoma.

Colon interposition is an established technique for esophageal reconstruction. We describe the case of primary adenocarcinoma arising in a colonic interposition graft that was performed after total esophagectomy for recurrence adenocarcinoma derived from the Barrett esophagus.

Intussusception of the small intestine caused by a primary melanoma?

Although the gastrointestinal tract is a fairly frequent site of melanoma metastases, reports of small bowel intussusception caused by melanoma are very rare. We report the case of a 77-year-old man who was admitted to our hospital with epigastric pain, melena and anaemia. After clinical examination, laboratory evaluation and radiological work-up the diagnosis of a jejunal intussusception was made. Exploratory laparoscopy revealed a large tumour arising from the jejunum, approximately 20 cm distal to the angle of Treitz. Small bowel resection with an end-to-end anastomosis was performed. Histological examination showed an intestinal melanoma. There are different theories concerning the origin of malignant melanoma in the small bowel. Although the small and large intestines normally contain no melanocytes, these cells have occasionally been found in the alimentary and respiratory tracts and even in lymph nodes, which supports the theory of a primary origin of melanoma at these sites. Since this was a solitary intestinal lesion and there was no history of cutaneous melanoma, we conclude that this could be an example of a very rare primary melanoma of the small intestine.