RESUMEN
BACKGROUND: Acute Generalized Exanthematous Pustulosis (AGEP) is a rare dermatologic reaction characterized by an erythematous rash with pustular erosions, fever and leukocytosis. Although most often secondary to antibiotic use, AGEP has also been associated with many drugs. A thorough literature search showed only four previously documented cases of ibuprofen-associated AGEP, and one case of dog bite-associated AGEP. CASE REPORT: We present the case of a 46â¯year old Caucasian female who developed AGEP after self-treating with ibuprofen for a dog bite. CONCLUSION: In the clinical setting this rash is often dramatic and illuminating the causative agent can be a diagnostic challenge. Our case represents a rare cause of AGEP and an important finding for current practitioners.
Asunto(s)
Pustulosis Exantematosa Generalizada Aguda/patología , Analgésicos no Narcóticos/efectos adversos , Analgésicos no Narcóticos/uso terapéutico , Mordeduras y Picaduras/patología , Ibuprofeno/efectos adversos , Dolor/tratamiento farmacológico , Pustulosis Exantematosa Generalizada Aguda/etiología , Pustulosis Exantematosa Generalizada Aguda/inmunología , Analgésicos no Narcóticos/administración & dosificación , Animales , Antibacterianos , Mordeduras y Picaduras/tratamiento farmacológico , Mordeduras y Picaduras/inmunología , Perros , Femenino , Fiebre , Humanos , Ibuprofeno/administración & dosificación , Persona de Mediana Edad , Resultado del TratamientoRESUMEN
BACKGROUND: Relapsing Polychondritis is a rare rheumatologic condition with multisystem involvement. Common presenting symptoms are auricular and nasal chondritis. Common complications include hearing loss and cardiac involvement. An extremely rare complication is neurological involvement. Case report. We present a case of relapsing polychondritis resulting in stroke and discuss the current literature on this condition. CONCLUSION: To our knowledge, only 6 previous documented cases of stroke secondary to relapsing polychondritis exist in the current literature. This case represents a rare but important complication of relapsing polychondritis.
RESUMEN
The treatment of cancer is a rapidly evolving field. As more chemotherapeutic agents become available, reporting the side effects of these agents in clinical practice becomes increasingly important. Nivolumab is one of the chemotherapeutic agents commonly used for treatment of renal cell carcinoma, metastatic melanoma, and metastatic non-small cell lung cancer. While common side effects are known and well documented, encephalitis is documented as an extremely rare side effect. We present the case of an extremely rare side effect to a common chemotherapeutic agent.