Asunto(s)
Talasemia , Adulto , Anemia Hipocrómica/etiología , Anemia Sideroblástica/etiología , Población Negra , Sangre , Transfusión Sanguínea , Recuento de Eritrocitos , Eritrocitos/citología , Eritrocitos Anormales , Femenino , Hematócrito , Hemoglobina C/análisis , Hemoglobina Falciforme/análisis , Hemoglobinas , Hemoglobinas Anormales/análisis , Heterocigoto , Humanos , Recién Nacido , Linaje , Embarazo , Complicaciones Hematológicas del Embarazo , Talasemia/genética , Talasemia/terapia , Cordón Umbilical , Estados UnidosRESUMEN
The presence of teardrop-shaped red cells in peripheral blood has traditionally been felt to reflect altered marrow architecture, namely myelofibrosis. We evaluated two patients with splenomegaly, moderately severe hemolytic anemia due to warm-reactive IgG anti-red cell autoantibody, and bone marrow erythroid hyperplasia without myelofibrosis. A striking predominance of teardrop-shaped red cells was noted upon examination of their blood films. Removal of a spleen containing extramedullary hematopoiesis in one and resolution of splenomegaly in the other were accompanied by disappearance of these cells. Our observations support a role for the spleen and for extramedullary hematopoiesis in the pathogenesis of this distinctive red cell morphologic abnormality.