1.
J Pharm Sci
; 68(4): 519-20, 1979 Apr.
Artículo
en Inglés
| MEDLINE
| ID: mdl-438986
RESUMEN
Substituted isatins and substituted acetophenones were condensed to give analogs of 3-hydroxy-3-phenacyloxindole. These alcohols were dehydrated, and the alkene was reduced. None of the products had the level of anticonvulsant activity exhibited by the parent compound.
Asunto(s)
Indoles/síntesis química , Animales , Anticonvulsivantes/síntesis química , Electrochoque , Indoles/farmacología , Oxindoles , Pentilenotetrazol/antagonistas & inhibidores , Fenilacetatos/síntesis química , Fenilacetatos/farmacología
2.
J Pharm Sci
; 69(10): 1235-7, 1980 Oct.
Artículo
en Inglés
| MEDLINE
| ID: mdl-6158569
RESUMEN
Substituted isatins were condensed with acetone and other ketones to give analogs of 3-hydroxy-3-acetonyloxindole. Some of these alcohols were dehydrated. Several compounds with anticonvulsant activity were obtained.