RESUMEN
Examination of 20 individuals without any pathological conditions of the cardiovascular system and 8 patients with myocardial hypertrophy has shown that the hypocalciemic hormone of the thyroid gland thyrocalcitonin has a certain negative inotropic effect and does not possess chrono- and dromotropic affects. The mechanism of the cardiac effect of thyrocalcitonin is evidently due to its effect on the metabolism of calcium and its transportation in the myocardial structures.
Asunto(s)
Calcitonina/uso terapéutico , Cardiomegalia/tratamiento farmacológico , Corazón/efectos de los fármacos , Adulto , Anciano , Cardiomegalia/fisiopatología , Ensayos Clínicos como Asunto , Relación Dosis-Respuesta a Droga , Evaluación de Medicamentos , Prueba de Esfuerzo , Femenino , Corazón/fisiología , Frecuencia Cardíaca/efectos de los fármacos , Humanos , Masculino , Persona de Mediana Edad , Contracción Miocárdica/efectos de los fármacos , Factores de TiempoAsunto(s)
Arritmias Cardíacas/tratamiento farmacológico , Calcitonina/uso terapéutico , Arritmias Cardíacas/sangre , Fibrilación Atrial/tratamiento farmacológico , Calcitonina/administración & dosificación , Calcitonina/efectos adversos , Calcio/sangre , Complejos Cardíacos Prematuros/tratamiento farmacológico , Cloro/sangre , Evaluación de Medicamentos , Femenino , Bloqueo Cardíaco/tratamiento farmacológico , Humanos , Inyecciones Intravenosas , Masculino , Ácidos Fosfóricos/sangre , Potasio/sangre , Sodio/sangre , Taquicardia/tratamiento farmacológicoAsunto(s)
Insuficiencia Cardíaca/tratamiento farmacológico , Nifedipino/uso terapéutico , Verapamilo/uso terapéutico , Calcio/sangre , Enfermedad Crónica , Evaluación de Medicamentos , Femenino , Insuficiencia Cardíaca/sangre , Insuficiencia Cardíaca/fisiopatología , Hemodinámica/efectos de los fármacos , Humanos , Masculino , Factores de TiempoRESUMEN
The results of the operative treatment of 277 patients with atrioventricular block and sick sinus syndrome were analysed. The primary implantation of the electrocardiostimulators (ECS) was performed in 211 (73.5%), the repeated one--in 76 (26.5%) patients. The complications of endocardial electrocardiostimulation developed in 58 (17.3%) patients, of them in 39 (14%), the repeated operative intervention was performed. Most frequently, the complications were conditioned by the quality of electrodes and ECG.
Asunto(s)
Estimulación Cardíaca Artificial/efectos adversos , Bloqueo Cardíaco/terapia , Síndrome del Seno Enfermo/terapia , Anciano , Electrodos Implantados , Falla de Equipo , Humanos , Persona de Mediana Edad , Marcapaso Artificial , ReimplantaciónRESUMEN
A study was made of the effect of the thyroid hormone thyrocalcitonin (TCT) on the electrolyte composition of the plasma and erythrocytes. In healthy persons and in the patients with various diseases of the cardiovascular system administration of 1 Unit of TCT per 1 kg of weight led to a significant reduction of the total plasma calcium and its diffusible fraction and also of plasma sodium. A course treatment with the hormone led to the enhancement of the hypocalciemic effect. In dogs administration of 10 Units of TCT per 1 kg of weight produced a more pronounced hypocalciemic effect. The rest of blood electrolytes displayed no significant changes.