Detalles de la búsqueda
1.
Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase.
Chemistry
; 28(40): e202200678, 2022 Jul 15.
Artículo
Inglés
| MEDLINE | ID: mdl-35420233
2.
In Situ Assembly of Choline Acetyltransferase Ligands by a Hydrothiolation Reaction Reveals Key Determinants for Inhibitor Design.
Angew Chem Int Ed Engl
; 60(2): 813-819, 2021 01 11.
Artículo
Inglés
| MEDLINE | ID: mdl-33079431
3.
Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6.
Proc Natl Acad Sci U S A
; 113(20): 5514-9, 2016 May 17.
Artículo
Inglés
| MEDLINE | ID: mdl-27140636
4.
An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet.
Molecules
; 22(9)2017 Aug 30.
Artículo
Inglés
| MEDLINE | ID: mdl-28867801
5.
The Nature of Activated Non-classical Hydrogen Bonds: A Case Study on Acetylcholinesterase-Ligand Complexes.
Chemistry
; 22(8): 2672-81, 2016 Feb 18.
Artículo
Inglés
| MEDLINE | ID: mdl-26751405
6.
Benefits of statistical molecular design, covariance analysis, and reference models in QSAR: a case study on acetylcholinesterase.
J Comput Aided Mol Des
; 29(3): 199-215, 2015 Mar.
Artículo
Inglés
| MEDLINE | ID: mdl-25351962
7.
Effects of Anticholinesterases on Catalysis and Induced Conformational Change of the Peripheral Anionic Site of Murine Acetylcholinesterase.
Pestic Biochem Physiol
; 106(3): 79-84, 2013 Jul 01.
Artículo
Inglés
| MEDLINE | ID: mdl-24003261
8.
Structure-Activity Relationships Reveal Beneficial Selectivity Profiles of Inhibitors Targeting Acetylcholinesterase of Disease-Transmitting Mosquitoes.
J Med Chem
; 66(9): 6333-6353, 2023 05 11.
Artículo
Inglés
| MEDLINE | ID: mdl-37094110
9.
Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures.
ACS Med Chem Lett
; 13(3): 499-506, 2022 Mar 10.
Artículo
Inglés
| MEDLINE | ID: mdl-35300078
10.
Physical Mechanisms Governing Substituent Effects on Arene-Arene Interactions in a Protein Milieu.
J Phys Chem B
; 124(30): 6529-6539, 2020 07 30.
Artículo
Inglés
| MEDLINE | ID: mdl-32610016
11.
Solution structure of poly(ethylene) glycol-conjugated hemoglobin revealed by small-angle X-ray scattering: implications for a new oxygen therapeutic.
Biophys J
; 94(1): 173-81, 2008 Jan 01.
Artículo
Inglés
| MEDLINE | ID: mdl-17827244
12.
Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation.
J Am Chem Soc
; 130(47): 16011-20, 2008 Nov 26.
Artículo
Inglés
| MEDLINE | ID: mdl-18975951
13.
Influence of Enantiomeric Inhibitors on the Dynamics of Acetylcholinesterase Measured by Elastic Incoherent Neutron Scattering.
J Phys Chem B
; 122(36): 8516-8525, 2018 09 13.
Artículo
Inglés
| MEDLINE | ID: mdl-30110543
14.
Noncovalent Inhibitors of Mosquito Acetylcholinesterase 1 with Resistance-Breaking Potency.
J Med Chem
; 61(23): 10545-10557, 2018 12 13.
Artículo
Inglés
| MEDLINE | ID: mdl-30339371
15.
Similar but different: thermodynamic and structural characterization of a pair of enantiomers binding to acetylcholinesterase.
Angew Chem Int Ed Engl
; 51(51): 12716-20, 2012 Dec 14.
Artículo
Inglés
| MEDLINE | ID: mdl-23161758
16.
N-Aryl-N'-ethyleneaminothioureas effectively inhibit acetylcholinesterase 1 from disease-transmitting mosquitoes.
Eur J Med Chem
; 134: 415-427, 2017 Jul 07.
Artículo
Inglés
| MEDLINE | ID: mdl-28433681
17.
Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates.
Biochem Pharmacol
; 72(5): 597-607, 2006 Aug 28.
Artículo
Inglés
| MEDLINE | ID: mdl-16876764
18.
Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting Mosquitoes.
J Med Chem
; 59(20): 9409-9421, 2016 Oct 27.
Artículo
Inglés
| MEDLINE | ID: mdl-27598521
19.
Acetylcholinesterases from the Disease Vectors Aedes aegypti and Anopheles gambiae: Functional Characterization and Comparisons with Vertebrate Orthologues.
PLoS One
; 10(10): e0138598, 2015.
Artículo
Inglés
| MEDLINE | ID: mdl-26447952
20.
Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity.
Biochem Pharmacol
; 85(9): 1389-97, 2013 May 01.
Artículo
Inglés
| MEDLINE | ID: mdl-23376121