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1.

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline.

Montagne, Axel; Nation, Daniel A; Sagare, Abhay P; Barisano, Giuseppe; Sweeney, Melanie D; Chakhoyan, Ararat; Pachicano, Maricarmen; Joe, Elizabeth; Nelson, Amy R; D'Orazio, Lina M; Buennagel, David P; Harrington, Michael G; Benzinger, Tammie L S; Fagan, Anne M; Ringman, John M; Schneider, Lon S; Morris, John C; Reiman, Eric M; Caselli, Richard J; Chui, Helena C; Tcw, Julia; Chen, Yining; Pa, Judy; Conti, Peter S; Law, Meng; Toga, Arthur W; Zlokovic, Berislav V.

Nature ; 581(7806): 71-76, 2020 05.

Artículo Inglés | MEDLINE | ID: mdl-32376954

2.

Change in Cerebrospinal Fluid Tau Microtubule Binding Region Detects Symptom Onset, Cognitive Decline, Tangles, and Atrophy in Dominantly Inherited Alzheimer's Disease.

Horie, Kanta; Li, Yan; Barthélemy, Nicolas R; Gordon, Brian; Hassenstab, Jason; Benzinger, Tammie L S; Fagan, Anne M; Morris, John C; Karch, Celeste M; Xiong, Chengjie; Allegri, Ricardo; Mendez, Patricio Chrem; Ikeuchi, Takeshi; Kasuga, Kensaku; Noble, James; Farlow, Martin; Chhatwal, Jasmeer; Day, Gregory; Schofield, Peter R; Masters, Colin L; Levin, Johannes; Jucker, Mathias; Lee, Jae-Hong; Roh, Jee Hoon; Sato, Chihiro; Sachdev, Pallavi; Koyama, Akihiko; Reyderman, Larisa; Bateman, Randall J; McDade, Eric.

Ann Neurol ; 93(6): 1158-1172, 2023 06.

Artículo Inglés | MEDLINE | ID: mdl-36843330

3.

Proteomic clusters underlie heterogeneity in preclinical Alzheimer's disease progression.

Wisch, Julie K; Butt, Omar H; Gordon, Brian A; Schindler, Suzanne E; Fagan, Anne M; Henson, Rachel L; Yang, Chengran; Boerwinkle, Anna H; Benzinger, Tammie L S; Holtzman, David M; Morris, John C; Cruchaga, Carlos; Ances, Beau M.

Brain ; 146(7): 2944-2956, 2023 07 03.

Artículo Inglés | MEDLINE | ID: mdl-36542469

4.

Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer's disease.

Wheelock, Muriah D; Strain, Jeremy F; Mansfield, Patricia; Tu, Jiaxin Cindy; Tanenbaum, Aaron; Preische, Oliver; Chhatwal, Jasmeer P; Cash, David M; Cruchaga, Carlos; Fagan, Anne M; Fox, Nick C; Graff-Radford, Neill R; Hassenstab, Jason; Jack, Clifford R; Karch, Celeste M; Levin, Johannes; McDade, Eric M; Perrin, Richard J; Schofield, Peter R; Xiong, Chengjie; Morris, John C; Bateman, Randal J; Jucker, Mathias; Benzinger, Tammie L S; Ances, Beau M; Eggebrecht, Adam T; Gordon, Brian A.

Brain ; 146(7): 2928-2943, 2023 07 03.

Artículo Inglés | MEDLINE | ID: mdl-36625756

5.

Amyloid-Related Imaging Abnormalities in the DIAN-TU-001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease.

Joseph-Mathurin, Nelly; Llibre-Guerra, Jorge J; Li, Yan; McCullough, Austin A; Hofmann, Carsten; Wojtowicz, Jakub; Park, Ethan; Wang, Guoqiao; Preboske, Gregory M; Wang, Qing; Gordon, Brian A; Chen, Charles D; Flores, Shaney; Aggarwal, Neelum T; Berman, Sarah B; Bird, Thomas D; Black, Sandra E; Borowski, Bret; Brooks, William S; Chhatwal, Jasmeer P; Clarnette, Roger; Cruchaga, Carlos; Fagan, Anne M; Farlow, Martin; Fox, Nick C; Gauthier, Serge; Hassenstab, Jason; Hobbs, Diana A; Holdridge, Karen C; Honig, Lawrence S; Hornbeck, Russ C; Hsiung, Ging-Yuek R; Jack, Clifford R; Jimenez-Velazquez, Ivonne Z; Jucker, Mathias; Klein, Gregory; Levin, Johannes; Mancini, Michele; Masellis, Mario; McKay, Nicole S; Mummery, Catherine J; Ringman, John M; Shimada, Hiroyuki; Snider, B Joy; Suzuki, Kazushi; Wallon, David; Xiong, Chengjie; Yaari, Roy; McDade, Eric; Perrin, Richard J.

Ann Neurol ; 92(5): 729-744, 2022 11.

Artículo Inglés | MEDLINE | ID: mdl-36151869

6.

Longitudinal head-to-head comparison of ¹¹C-PiB and ¹⁸F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-ß monoclonal antibodies in dominantly inherited Alzheimer's disease.

Chen, Charles D; McCullough, Austin; Gordon, Brian; Joseph-Mathurin, Nelly; Flores, Shaney; McKay, Nicole S; Hobbs, Diana A; Hornbeck, Russ; Fagan, Anne M; Cruchaga, Carlos; Goate, Alison M; Perrin, Richard J; Wang, Guoqiao; Li, Yan; Shi, Xinyu; Xiong, Chengjie; Pontecorvo, Michael J; Klein, Gregory; Su, Yi; Klunk, William E; Jack, Clifford; Koeppe, Robert; Snider, B Joy; Berman, Sarah B; Roberson, Erik D; Brosch, Jared; Surti, Ghulam; Jiménez-Velázquez, Ivonne Z; Galasko, Douglas; Honig, Lawrence S; Brooks, William S; Clarnette, Roger; Wallon, David; Dubois, Bruno; Pariente, Jérémie; Pasquier, Florence; Sanchez-Valle, Raquel; Shcherbinin, Sergey; Higgins, Ixavier; Tunali, Ilke; Masters, Colin L; van Dyck, Christopher H; Masellis, Mario; Hsiung, Robin; Gauthier, Serge; Salloway, Steve; Clifford, David B; Mills, Susan; Supnet-Bell, Charlene; McDade, Eric.

Eur J Nucl Med Mol Imaging ; 50(9): 2669-2682, 2023 07.

Artículo Inglés | MEDLINE | ID: mdl-37017737

7.

Unsupervised high-frequency smartphone-based cognitive assessments are reliable, valid, and feasible in older adults at risk for Alzheimer's disease.

Nicosia, Jessica; Aschenbrenner, Andrew J; Balota, David A; Sliwinski, Martin J; Tahan, Marisol; Adams, Sarah; Stout, Sarah S; Wilks, Hannah; Gordon, Brian A; Benzinger, Tammie L S; Fagan, Anne M; Xiong, Chengjie; Bateman, Randall J; Morris, John C; Hassenstab, Jason.

J Int Neuropsychol Soc ; 29(5): 459-471, 2023 06.

Artículo Inglés | MEDLINE | ID: mdl-36062528

8.

Preclinical Alzheimer's disease biomarkers accurately predict cognitive and neuropathological outcomes.

Long, Justin M; Coble, Dean W; Xiong, Chengjie; Schindler, Suzanne E; Perrin, Richard J; Gordon, Brian A; Benzinger, Tammie L S; Grant, Elizabeth; Fagan, Anne M; Harari, Oscar; Cruchaga, Carlos; Holtzman, David M; Morris, John C.

Brain ; 145(12): 4506-4518, 2022 12 19.

Artículo Inglés | MEDLINE | ID: mdl-35867858

9.

A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment.

Levey, Allan I; Qiu, Deqiang; Zhao, Liping; Hu, William T; Duong, Duc M; Higginbotham, Lenora; Dammer, Eric B; Seyfried, Nicholas T; Wingo, Thomas S; Hales, Chadwick M; Gámez Tansey, Malú; Goldstein, David S; Abrol, Anees; Calhoun, Vince D; Goldstein, Felicia C; Hajjar, Ihab; Fagan, Anne M; Galasko, Doug; Edland, Steven D; Hanfelt, John; Lah, James J; Weinshenker, David.

Brain ; 145(6): 1924-1938, 2022 06 30.

Artículo Inglés | MEDLINE | ID: mdl-34919634

10.

Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan.

Luo, Jingqin; Agboola, Folasade; Grant, Elizabeth; Morris, John C; Masters, Colin L; Albert, Marilyn S; Johnson, Sterling C; McDade, Eric M; Fagan, Anne M; Benzinger, Tammie L S; Hassenstab, Jason; Bateman, Randall J; Perrin, Richard J; Wang, Guoqiao; Li, Yan; Gordon, Brian; Cruchaga, Carlos; Day, Gregory S; Levin, Johannes; Vöglein, Jonathan; Ikeuchi, Takeshi; Suzuki, Kazushi; Allegri, Ricardo F; Xiong, Chengjie.

Brain ; 145(12): 4459-4473, 2022 12 19.

Artículo Inglés | MEDLINE | ID: mdl-35925685

11.

Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology.

Morris, John C; Weiner, Michael; Xiong, Chengjie; Beckett, Laurel; Coble, Dean; Saito, Naomi; Aisen, Paul S; Allegri, Ricardo; Benzinger, Tammie L S; Berman, Sarah B; Cairns, Nigel J; Carrillo, Maria C; Chui, Helena C; Chhatwal, Jasmeer P; Cruchaga, Carlos; Fagan, Anne M; Farlow, Martin; Fox, Nick C; Ghetti, Bernardino; Goate, Alison M; Gordon, Brian A; Graff-Radford, Neill; Day, Gregory S; Hassenstab, Jason; Ikeuchi, Takeshi; Jack, Clifford R; Jagust, William J; Jucker, Mathias; Levin, Johannes; Massoumzadeh, Parinaz; Masters, Colin L; Martins, Ralph; McDade, Eric; Mori, Hiroshi; Noble, James M; Petersen, Ronald C; Ringman, John M; Salloway, Stephen; Saykin, Andrew J; Schofield, Peter R; Shaw, Leslie M; Toga, Arthur W; Trojanowski, John Q; Vöglein, Jonathan; Weninger, Stacie; Bateman, Randall J; Buckles, Virginia D.

Brain ; 145(10): 3594-3607, 2022 10 21.

Artículo Inglés | MEDLINE | ID: mdl-35580594

12.

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.

Shi, Yang; Yamada, Kaoru; Liddelow, Shane Antony; Smith, Scott T; Zhao, Lingzhi; Luo, Wenjie; Tsai, Richard M; Spina, Salvatore; Grinberg, Lea T; Rojas, Julio C; Gallardo, Gilbert; Wang, Kairuo; Roh, Joseph; Robinson, Grace; Finn, Mary Beth; Jiang, Hong; Sullivan, Patrick M; Baufeld, Caroline; Wood, Michael W; Sutphen, Courtney; McCue, Lena; Xiong, Chengjie; Del-Aguila, Jorge L; Morris, John C; Cruchaga, Carlos; Fagan, Anne M; Miller, Bruce L; Boxer, Adam L; Seeley, William W; Butovsky, Oleg; Barres, Ben A; Paul, Steven M; Holtzman, David M.

Nature ; 549(7673): 523-527, 2017 09 28.

Artículo Inglés | MEDLINE | ID: mdl-28959956

13.

Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's disease.

Xiong, Chengjie; McCue, Lena M; Buckles, Virginia; Grant, Elizabeth; Agboola, Folasade; Coble, Dean; Bateman, Randall J; Fagan, Anne M; Benzinger, Tammie L S; Hassenstab, Jason; Schindler, Suzanne E; McDade, Eric; Moulder, Krista; Gordon, Brian A; Cruchaga, Carlos; Day, Gregory S; Ikeuchi, Takeshi; Suzuki, Kazushi; Allegri, Ricardo F; Vöglein, Jonathan; Levin, Johannes; Morris, John C.

Alzheimers Dement ; 19(7): 2923-2932, 2023 07.

Artículo Inglés | MEDLINE | ID: mdl-36640138

14.

Higher systolic blood pressure in early-mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non-carriers. Results from the DIAN study.

Xu, Ying; Aung, Htein Linn; Bateman, Randall J; Brooks, William S; Chhatwal, Jasmeer; Day, Gregory S; Fagan, Anne M; Farlow, Martin R; Gordon, Brian; Kehoe, Patrick G; Levin, Johannes; Mori, Hiroshi; Morris, John C; Wharton, Whitney; Humburg, Peter; Schofield, Peter R; Peters, Ruth.

Alzheimers Dement ; 19(11): 4999-5009, 2023 Nov.

Artículo Inglés | MEDLINE | ID: mdl-37087693

15.

Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aß-PET, neurodegeneration, and cognition.

Chatterjee, Pratishtha; Vermunt, Lisa; Gordon, Brian A; Pedrini, Steve; Boonkamp, Lynn; Armstrong, Nicola J; Xiong, Chengjie; Singh, Abhay K; Li, Yan; Sohrabi, Hamid R; Taddei, Kevin; Molloy, Mark; Benzinger, Tammie L S; Morris, John C; Karch, Celeste; Berman, Sarah; Chhatwal, Jasmeer; Cruchaga, Carlos; Graff-Radford, Neill R; Day, Gregory S; Farlow, Martin; Fox, Nick; Goate, Alison; Hassenstab, Jason; Lee, Jae-Hong; Levin, Johannes; McDade, Eric; Mori, Hiroshi; Perrin, Richard; Sanchez-Valle, Raquel; Schofield, Peter R; Levey, Allan; Jucker, Mathias; Masters, Colin L; Fagan, Anne M; Bateman, Randall J; Martins, Ralph N; Teunissen, Charlotte.

Alzheimers Dement ; 19(7): 2790-2804, 2023 07.

Artículo Inglés | MEDLINE | ID: mdl-36576155

16.

Biomarker clustering in autosomal dominant Alzheimer's disease.

Luckett, Patrick H; Chen, Charlie; Gordon, Brian A; Wisch, Julie; Berman, Sarah B; Chhatwal, Jasmeer P; Cruchaga, Carlos; Fagan, Anne M; Farlow, Martin R; Fox, Nick C; Jucker, Mathias; Levin, Johannes; Masters, Colin L; Mori, Hiroshi; Noble, James M; Salloway, Stephen; Schofield, Peter R; Brickman, Adam M; Brooks, William S; Cash, David M; Fulham, Michael J; Ghetti, Bernardino; Jack, Clifford R; Vöglein, Jonathan; Klunk, William E; Koeppe, Robert; Su, Yi; Weiner, Michael; Wang, Qing; Marcus, Daniel; Koudelis, Deborah; Joseph-Mathurin, Nelly; Cash, Lisa; Hornbeck, Russ; Xiong, Chengjie; Perrin, Richard J; Karch, Celeste M; Hassenstab, Jason; McDade, Eric; Morris, John C; Benzinger, Tammie L S; Bateman, Randall J; Ances, Beau M.

Alzheimers Dement ; 19(1): 274-284, 2023 01.

Artículo Inglés | MEDLINE | ID: mdl-35362200

17.

Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study.

Dage, Jeffrey L; Eloyan, Ani; Thangarajah, Maryanne; Hammers, Dustin B; Fagan, Anne M; Gray, Julia D; Schindler, Suzanne E; Snoddy, Casey; Nudelman, Kelly N H; Faber, Kelley M; Foroud, Tatiana; Aisen, Paul; Griffin, Percy; Grinberg, Lea T; Iaccarino, Leonardo; Kirby, Kala; Kramer, Joel; Koeppe, Robert; Kukull, Walter A; La Joie, Renaud; Mundada, Nidhi S; Murray, Melissa E; Rumbaugh, Malia; Soleimani-Meigooni, David N; Toga, Arthur W; Touroutoglou, Alexandra; Vemuri, Prashanthi; Atri, Alireza; Beckett, Laurel A; Day, Gregory S; Graff-Radford, Neill R; Duara, Ranjan; Honig, Lawrence S; Jones, David T; Masdeu, Joseph C; Mendez, Mario F; Musiek, Erik; Onyike, Chiadi U; Riddle, Meghan; Rogalski, Emily; Salloway, Stephen; Sha, Sharon J; Turner, Raymond S; Wingo, Thomas S; Wolk, David A; Womack, Kyle B; Carrillo, Maria C; Dickerson, Bradford C; Rabinovici, Gil D; Apostolova, Liana G.

Alzheimers Dement ; 19 Suppl 9: S115-S125, 2023 11.

Artículo Inglés | MEDLINE | ID: mdl-37491668

18.

Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease.

Millar, Peter R; Luckett, Patrick H; Gordon, Brian A; Benzinger, Tammie L S; Schindler, Suzanne E; Fagan, Anne M; Cruchaga, Carlos; Bateman, Randall J; Allegri, Ricardo; Jucker, Mathias; Lee, Jae-Hong; Mori, Hiroshi; Salloway, Stephen P; Yakushev, Igor; Morris, John C; Ances, Beau M.

Neuroimage ; 256: 119228, 2022 08 01.

Artículo Inglés | MEDLINE | ID: mdl-35452806

19.

Cerebrospinal fluid neurofilament light chain is a marker of aging and white matter damage.

Meeker, Karin L; Butt, Omar H; Gordon, Brian A; Fagan, Anne M; Schindler, Suzanne E; Morris, John C; Benzinger, Tammie L S; Ances, Beau M.

Neurobiol Dis ; 166: 105662, 2022 05.

Artículo Inglés | MEDLINE | ID: mdl-35167933

20.

CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease.

Strain, Jeremy F; Barthelemy, Nicolas; Horie, Kanta; Gordon, Brian A; Kilgore, Collin; Aschenbrenner, Andrew; Cruchaga, Carlos; Xiong, Chengjie; Joseph-Mathurin, Nelly; Hassenstab, Jason; Fagan, Anne M; Li, Yan; Karch, Celeste M; Perrin, Richard J; Berman, Sarah B; Chhatwal, Jasmeer P; Graff-Radford, Neill R; Mori, Hiroshi; Levin, Johannes; Noble, James M; Allegri, Ricardo; Schofield, Peter R; Marcus, Daniel S; Holtzman, David M; Morris, John C; Benzinger, Tammie L S; McDade, Eric M; Bateman, Randall J; Ances, Beau M.

Neurobiol Dis ; 168: 105714, 2022 06 15.

Artículo Inglés | MEDLINE | ID: mdl-35358703

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