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1.
Gynecol Endocrinol ; 35(4): 314-319, 2019 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-30626251

RESUMEN

In this single-center matched-cohort study, women who underwent IVF/ICSI with donor oocytes between 2007 and 2014 (n = 259) were compared to women undergoing autologous cycles during the same time period (n = 515). The matching (1:2) took into consideration the women's age, type of treatment (IVF/ICSI), and year of embryo transfer. All women were healthy and below 40 years of age at the time of IVF/ICSI, and the treatments were performed using a strict policy of single embryo transfer. Multiple logistic regression analysis, adjusted for body mass index (BMI), smoking, and parity, showed a four times increased risk of gestational hypertensive disorders (adjusted odds ratio, AOR 4.25; 95% confidence interval (CI), 2.61-6.92) and pre-eclampsia (AOR 3.99; 95% CI 2.27-7.00) in pregnancies achieved with donor oocytes. There was also a higher rate of cesarean section in women who gave birth after oocyte donation (AOR 1.69; 95% CI 1.22-2.35) and a higher risk of postpartum hemorrhage >1000 mL (AOR 1.59; 95% CI, 1.11-2.27). After further adjustment for preeclampsia in the logistic regression analysis, no additional increased perinatal risks were found. The incidence of preterm delivery, low weight at birth, need of neonatal intensive care, Apgar scores, and incidence of perinatal death were also similar between the groups.


Asunto(s)
Peso al Nacer , Cesárea/estadística & datos numéricos , Complicaciones del Trabajo de Parto/epidemiología , Donación de Oocito/efectos adversos , Preeclampsia/epidemiología , Adulto , Puntaje de Apgar , Femenino , Humanos , Recién Nacido , Complicaciones del Trabajo de Parto/etiología , Preeclampsia/etiología , Embarazo , Estudios Prospectivos , Transferencia de un Solo Embrión , Suecia/epidemiología , Adulto Joven
2.
J Womens Health (Larchmt) ; 27(7): 939-945, 2018 07.
Artículo en Inglés | MEDLINE | ID: mdl-29715049

RESUMEN

BACKGROUND: Egg donation is a common fertility treatment in female cancer survivors with reproductive wish and iatrogenic ovarian failure. We examined whether women previously treated for cancer have a higher risk of pregnancy complications after egg donation treatments when compared to women without cancer history. METHODS: In this prospective cohort treated during 2003-2015 at a single center, 31 women with previous history of cancer achieved 25 deliveries and 212 women without cancer history achieved 244 deliveries. All egg donor treatments were performed with a strict policy of single embryo transfer to reduce pregnancy and perinatal complications. Data were analyzed using logistic regression with adjustment for relevant confounders, to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for perinatal and obstetric outcomes. Women without previous history of cancer were used as the reference group in the regression models. RESULTS: Women with a history of cancer presented with a significantly increased risk of pregnancy complications, including preterm birth (aOR 5.54, 95% CI 2.01-15.31) and preeclampsia (aOR 2.79, 95% CI 1.07-7.34), compared to women without cancer history. CONCLUSIONS: The findings of this study suggest that the risks of preterm birth and preeclampsia in women with prior cancers who become pregnant by egg donor treatment significantly exceed those of women without cancer history undergoing similar treatments. As pregnancies using donor eggs are already acknowledged of higher risk for hypertensive pathologies, this study alerts toward characterization of specific increased risks in women who are cancer survivors to provide adapted pregnancy monitoring.


Asunto(s)
Supervivientes de Cáncer , Fertilización In Vitro , Neoplasias , Donación de Oocito , Evaluación de Resultado en la Atención de Salud/estadística & datos numéricos , Sistema de Registros , Técnicas Reproductivas Asistidas/estadística & datos numéricos , Adulto , Femenino , Humanos , Recién Nacido , Nacimiento Vivo/epidemiología , Neoplasias/epidemiología , Preeclampsia/epidemiología , Embarazo , Complicaciones del Embarazo/epidemiología , Resultado del Embarazo , Nacimiento Prematuro/epidemiología , Estudios Prospectivos
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