1.
Arch Pharm (Weinheim)
; 345(4): 294-301, 2012 Apr.
Artículo
en Inglés
| MEDLINE
| ID: mdl-22147525
RESUMEN
The synthesis of a series of novel α-aminosubstituted phosphonates was accomplished by the reaction of various substituted aldehydes with an amine amlodipine (3-ethyl 5-methyl (±)2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridene-3,5-dicarboxylate) followed by diethylphosphite/dibutylphosphite in ethanol using SnCl(2).2H(2)O as a Lewis acid catalyst, under conventional and ultrasonic irradiation. Their structures were established by analytical and spectral data. The title compounds showed good antibacterial, antifungal and antiviral activity depending on the nature of the bioactive groups at the α-carbon.