RESUMEN
Opioids trigger myelin insulation of reward circuit axons in a feedforward loop of addiction.
Asunto(s)
Analgésicos Opioides , Humanos , Analgésicos Opioides/farmacología , Animales , Axones/metabolismo , Axones/fisiología , Vaina de Mielina/metabolismo , Recompensa , Trastornos Relacionados con OpioidesRESUMEN
Targeting a driver of TBK1 kinase activity may slow the growth of kidney tumors.
Asunto(s)
Carcinoma de Células Renales , Neoplasias Renales , Humanos , Proteínas Serina-Treonina Quinasas/genética , Proteínas Serina-Treonina Quinasas/metabolismo , Fosforilación , Neoplasias Renales/genéticaRESUMEN
Blocking complement signaling biases microglia to destroy amyloid aggregates, not neuronal synapses.
Asunto(s)
Enfermedad de Alzheimer , Microglía , Humanos , Neuronas , Transducción de Señal , SinapsisRESUMEN
Astrocyte-secreted neurocan guides the formation of inhibitory circuits in the brain.
Asunto(s)
Sinapsis , Sinapsis/fisiología , Sinapsis/metabolismo , Humanos , Animales , Neuroglía/metabolismo , Neuroglía/fisiología , Neuroglía/citología , Astrocitos/metabolismo , Astrocitos/citología , Astrocitos/fisiología , Neurogénesis/fisiología , Encéfalo/fisiología , Encéfalo/metabolismoRESUMEN
Glia take up and detoxify neurotoxic lipids on a wake-sleep cycle, in turn promoting healthy sleep.
Asunto(s)
Neuroglía , Sueño , Animales , Humanos , Neuroglía/metabolismo , Neuroglía/fisiología , Sueño/fisiología , Vigilia/fisiologíaRESUMEN
YTHDC1 activates the DNA repair kinase ATR to suppress bleomycin-induced lung fibrosis.
Asunto(s)
Fibrosis Pulmonar , Humanos , Reparación del ADNRESUMEN
Highlights from the Science family of journals.
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Highlights from the Science family of journals.
RESUMEN
Highlights from the Science family of journals.
RESUMEN
Highlights from the Science family of journals.
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Highlights from the Science family of journals.
RESUMEN
Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
RESUMEN
Several studies show that there is still much to learn about cell death mechanisms.
Asunto(s)
Aprendizaje , Piroptosis , Muerte CelularRESUMEN
Co-targeting glial cells may block the paradoxical increase in pain caused by repeated opioid use.
Asunto(s)
Analgésicos Opioides , Neuroglía , Humanos , Analgésicos Opioides/efectos adversos , Dolor/inducido químicamenteRESUMEN
EZH2 inhibitors may slow the progression of an aggressive form of adrenocortical cancer.
Asunto(s)
Neoplasias de la Corteza Suprarrenal , Proteína Potenciadora del Homólogo Zeste 2 , Humanos , Proteína Potenciadora del Homólogo Zeste 2/genética , Proteína Potenciadora del Homólogo Zeste 2/metabolismo , Neoplasias de la Corteza Suprarrenal/genética , Inhibidores Enzimáticos/farmacología , Epigénesis GenéticaRESUMEN
A five-signal cue drives the switch to glia production in the developing fetal brain.
RESUMEN
The loss of a secreted factor from astrocytes may underlie neuronal pathology in Fragile X syndrome.
Asunto(s)
Astrocitos , Síndrome del Cromosoma X Frágil , Humanos , Transporte Biológico , Síndrome del Cromosoma X Frágil/genéticaRESUMEN
A high-protein diet may promote deep sleep by gut secretion of a dopamine neuron-stimulating peptide.