RESUMEN
The authors aimed at studying wave structure of the heart rhythm of patients with II stage hypertension disease without and with physical activity. 72 patients with II stage hypertension disease (47 men and 33 women) have been observed. Investigators used national bicycle ergometer complex called VRR (Kiev, design office "Ergometr"). Indices of spectral analysis of the heart rhythm at rest and recovery period have been calculated. Bicycle ergometer diagnostic was carried out using continuously graduated increase of physical activity. Patients with II stage hypertension disease were found to have at rest the tendency to the increase of slow II grade waves and centralization index but indices of wave structure of heart rhythm at the period of recovery were not changed.
Asunto(s)
Presión Sanguínea/fisiología , Frecuencia Cardíaca/fisiología , Hipertensión/fisiopatología , Prueba de Esfuerzo , Femenino , Humanos , Masculino , Persona de Mediana Edad , Índice de Severidad de la EnfermedadRESUMEN
Sympatho-adrenal activity (SAA) was assessed in 67 male patients with essential hypertension and 20 normal subjects. The patients were divided into 2 groups: those with increased (group 1) and normal (group 2) basal SAA. Hyperreactive and normally reactive patients were identified on the basis of plasma norepinephrine elevation in response to one-hour walking in both groups. Therapy with nifedipine alone for 3 weeks was ineffective in hyperreactive first-group patients. The efficiency of nifedipine treatment for essential hypertension may be dependent on baseline sympatho-adrenal activity and reactivity.
Asunto(s)
Glándulas Suprarrenales/efectos de los fármacos , Hipertensión/tratamiento farmacológico , Nifedipino/uso terapéutico , Sistema Nervioso Simpático/efectos de los fármacos , Glándulas Suprarrenales/fisiopatología , Adulto , Presión Sanguínea/efectos de los fármacos , Evaluación de Medicamentos , Humanos , Hipertensión/fisiopatología , Masculino , Sistema Nervioso Simpático/fisiopatología , Factores de TiempoRESUMEN
A total of 127 patients with bronchial asthma of infectious-allergic genesis and chronic obstructive bronchitis were examined for the central and regional hemodynamics as well as for the blood levels of serotonin and monoamine oxidase. The combination of chronic bronchial obstruction with stable "pulmogenic" arterial hypertension was associated with a significantly decreased cardiac index, a reduction in the pulse blood filling of the brain as well as an increase in the peripheral vascular resistance, the pressure in the pulmonary artery, serotonin levels and monoamine oxidase activity. A multiple modality therapy (hydralazin, talinolol, hydrochlorothiazide) elicited an improvement of the hemodynamic and normalization of the biochemical parameters.
Asunto(s)
Asma/fisiopatología , Bronquitis/fisiopatología , Hipertensión/etiología , Adulto , Enfermedad Crónica , Quimioterapia Combinada , Femenino , Hemodinámica , Humanos , Hidralazina/administración & dosificación , Hidroclorotiazida/administración & dosificación , Hipertensión/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Monoaminooxidasa/sangre , Propanolaminas/administración & dosificación , Serotonina/sangreRESUMEN
The plasma level of atrial natriuretic factor and its relation to intracardiac and systemic hemodynamic parameters were examined in patients with coronary heart, rheumatic and mitral valvular diseases, neurocirculatory dystonia which were complicated by atrial fibrillation. The concentration of atrial natriuretic factor was found to vary with the left ventricular myocardial mass, left atrial contractility, antiarrhythmic therapy intensity and efficacy.
Asunto(s)
Fibrilación Atrial/sangre , Factor Natriurético Atrial/sangre , Ventrículos Cardíacos/patología , Contracción Miocárdica/fisiología , Adulto , Anciano , Fibrilación Atrial/etiología , Fibrilación Atrial/patología , Fibrilación Atrial/fisiopatología , Enfermedades Cardiovasculares/sangre , Enfermedades Cardiovasculares/complicaciones , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
The state of regional hemodynamics (pulmonary, cerebral and peripheral) was studied in patients suffering from chronic obstructive bronchitis with symptomatic "pulmonogenic" hypertension. Pronounced disorders of regional hemodynamics accompanied by pulmonary hypertension, an increase in the tone of the cerebral and peripheral vessels and their lowered blood filling in patients with a stable phase of this type of hypertension, were established. Multimodality therapy including antihypertensive drugs (Cordanum, clonidine, hydrochlorothiazide, hydrolasin) significantly improved regional hemodynamics.
Asunto(s)
Bronquitis/fisiopatología , Hipertensión/fisiopatología , Adolescente , Adulto , Anciano , Antihipertensivos/uso terapéutico , Bronquitis/tratamiento farmacológico , Enfermedad Crónica , Femenino , Hemodinámica/efectos de los fármacos , Humanos , Hidralazina/uso terapéutico , Hipertensión/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Flujo Sanguíneo Regional/efectos de los fármacosRESUMEN
AIM: Assessment of efficiency and safety of enalapril (enap) and its combination with hydrochlorotiaside (enap-N). MATERIALS AND METHODS: 127 patients with mild and moderate blood hypertension entered an open non-comparative multicenter trial. 60 of them received enap (group 1), 67--enap N (group 2). Group 1 patients were given enap for 2 weeks in a dose 10 mg/day. If this dose was not adequate to normalize blood pressure, it was raised to 20-40 mg/day. Patients of group 2 received enap-N one tablet a day for 3 weeks. If the pressure persisted higher than 140/90 mm Hg, the treatment was continued for 3 weeks more in a dose of 2 tablets a day. RESULTS: Blood pressure lowered under 140/90 mm Hg in 40 patients of group 1 (66.7%). Systolic pressure dropped by 10 mm Hg minimum and diastolic by 5 mm minimum in 18 group 1 patients (30%). Enap-N reduced blood pressure under 140-90 mm Hg in 44 of 67 patients (65.7%). Systolic and diastolic pressure dropped, respectively, in 23(34.3%) patients. CONCLUSION: Enap and enap-N tablets were found highly effective and well tolerated. Side effects were caused by lowering of blood pressure.
Asunto(s)
Inhibidores de la Enzima Convertidora de Angiotensina/uso terapéutico , Enalapril/uso terapéutico , Hipertensión/tratamiento farmacológico , Administración Oral , Adolescente , Adulto , Inhibidores de la Enzima Convertidora de Angiotensina/administración & dosificación , Presión Sanguínea/efectos de los fármacos , Diuréticos , Quimioterapia Combinada , Enalapril/administración & dosificación , Estudios de Seguimiento , Humanos , Hidroclorotiazida/administración & dosificación , Hidroclorotiazida/uso terapéutico , Hipertensión/diagnóstico , Hipertensión/fisiopatología , Persona de Mediana Edad , Seguridad , Índice de Severidad de la Enfermedad , Inhibidores de los Simportadores del Cloruro de Sodio/administración & dosificación , Inhibidores de los Simportadores del Cloruro de Sodio/uso terapéutico , Resultado del TratamientoRESUMEN
Echocardioscopy in M- and B-modes with measurement of routine parameters of central hemodynamics and thickness of carotid intimal-medial segment as well as radioimmunoassay of plasma concentrations of atrial natriuretic peptide (ANUP) were performed in 159 patients aged 42-63 years (17 healthy subjects and 142 patients with cardiac failure associated with ischemic heart disease and sinus rhythm, without history of myocardial infarction). The results were indicative of possible use of ANUP as a marker of initial cardiac insufficiency and a corrector of the disease prognosis.
Asunto(s)
Factor Natriurético Atrial/sangre , Atrios Cardíacos/metabolismo , Insuficiencia Cardíaca/sangre , Disfunción Ventricular Izquierda/sangre , Adulto , Factor Natriurético Atrial/metabolismo , Biomarcadores/sangre , Gasto Cardíaco , Arterias Carótidas/diagnóstico por imagen , Ecocardiografía , Atrios Cardíacos/diagnóstico por imagen , Insuficiencia Cardíaca/complicaciones , Insuficiencia Cardíaca/fisiopatología , Humanos , Persona de Mediana Edad , Contracción Miocárdica , Isquemia Miocárdica/sangre , Isquemia Miocárdica/complicaciones , Isquemia Miocárdica/fisiopatología , Pronóstico , Radioinmunoensayo , Disfunción Ventricular Izquierda/complicaciones , Disfunción Ventricular Izquierda/fisiopatologíaRESUMEN
On the basis of findings from examination of 82 patients with ischemic heart disease presenting with exertional angina, functional class II-III, aged 62-86 years, efficacy was studied of an amino acid metabolic complex consisting of glutamic acid and methionine combined with basic antianginal drugs and single basic therapy with nitrates and calcium antagonists. Criteria for efficacy were condition of central cardiohemodynamics and inotropic indices. Glutamic acid and methionine combined with basic agents were found to make for enhancement of contractile function of ischemized myocardium, with the left ventricular local contractility being improved against the background of reduction in postload.
Asunto(s)
Ácido Glutámico/uso terapéutico , Corazón/efectos de los fármacos , Metionina/uso terapéutico , Isquemia Miocárdica/tratamiento farmacológico , Anciano , Anciano de 80 o más Años , Angina de Pecho/tratamiento farmacológico , Angina de Pecho/fisiopatología , Combinación de Medicamentos , Quimioterapia Combinada , Corazón/fisiopatología , Hemodinámica/efectos de los fármacos , Humanos , Persona de Mediana Edad , Isquemia Miocárdica/fisiopatología , Esfuerzo Físico , Factores de TiempoRESUMEN
A study made of the external respiration function and pulmonary hemodynamics in 43 patients with chronic obstructive pulmonary diseases by fluorography and tomography disclosed highly significant signs of impairement of the external respiration function and pulmonary hemodynamics at early stages in the course of these conditions' development. The above findings are confirmed by a series of non-invasive techniques of investigation, such as radiopulmonography, jugular phlebography, tetrapolar pulmonary rheoplethismography.