[Vulvar squamous cell carcinoma in young women with HPV negative]. / Carcinoma epidermoide de vulva en mujer joven con VPH negative.

BACKGROUND: The vulvar cancer is the fourth more frequent neoplasia after the endometrial, cervix and ovarian cancer. Normally, it has been related to old women of ages from 70 to 80 years old. Rarely, it has been detected cases in adult or young women. However, its incidence has been increased in the last years and in more early years. It is for this change in the incidence and its appearance in early years why a possible etiology has been looked for, opening different hypothesis that go from that related to the HPV to those that study an inflammatory chronic process as the basis for the carcinogenesis. CLINICAL CASE: In this article, it has been presented the case of a woman who is 34 years old with negative VPH that made her debut with epidermoid carcinoma of the vulva moderately different and on purpose of the case, we do a revision of the literature existent. CONCLUSIONS: Vulvar cancer diagnosed in young women as in older, but with different trends, risk factors and natural history. The case reported here escapes the theories studied so far so needed new lines of inquiry to investigate this form of presentation young woman, without HPV infection.

Linfangioleiomiomatosis / Lymphangioleiomyomatosis

Resumen. La linfangioleiomiomatosis (LAM) es una enfermedad poco frecuente caracterizada por una proliferación anormal de células del músculo liso, fundamentalmente a nivel pulmonar. Afecta generalmente a mujeres en edad fértil. La forma de presentación clínica más frecuente es la disnea de esfuerzo. En relación a las pruebas de imagen cabe destacar la inespecificidad de la radiografía simple de tórax, en parte debido a la aparición tardía de alteraciones en la misma. La tomografia computarizada (TC) torácica muestra, de una manera característica, imágenes quísticas de pared fina distribuidas uniformemente por todo el parénquima pulmonar. La biopsia pulmonar constituye el método diagnóstico definitivo. Presentamos los casos de 6 pacientes diagnosticadas de LAM en el área 1 de Madrid (AU)

Abstract. Lymphangioleiomyomatosis (LAM) is a rare disease characterized by abnormal smooth muscle cell proliferation throughout the bronchioles, basically in the lung. It generally affects child-bearing aged women. Its most frequent clinical presentation form is exertional dyspnea. In relationship with the imaging test, the non-specificity of the simple chest x-ray, partially due to the later appearance of its alterations, stands out. The thoracic CT scan (CT) characteristically shows cystic images of the thin cystic wall uniformly distributed throughout the pulmonary parenchyma. The lung biopsy is a definitive diagnostic method. We present the cases of 6 patients diagnosed of LAM in area 1 of Madrid (AU)