1.
J Org Chem
; 74(24): 9546-9, 2009 Dec 18.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19924876
RESUMEN
The asymmetric total synthesis of (+)-crassalactone D (4), a naturally occurring antitumor agent, has been achieved by employing an oxidative spirocyclization of furan 11 as the key step. Two close analogues, 7-epi-crassalactone D (14) and 5-epi-7-epi-crassalactone D (15), also have been prepared in the course of the synthesis of (+)-crassalactone D.
Asunto(s)
Antineoplásicos Fitogénicos/síntesis química , Furanos/síntesis química , Compuestos de Espiro/síntesis química , Antineoplásicos Fitogénicos/química , Ciclización , Furanos/química , Compuestos de Espiro/química , Estereoisomerismo
2.
Bioorg Med Chem Lett
; 18(9): 2845-9, 2008 May 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-18424044
RESUMEN
Introduction of the phenyl piperidinone and phenyl pyridinone P4 moieties in the anthranilamide scaffold led to potent, selective, and orally bioavailable inhibitors of factor Xa. Anthranilamide 28 displayed comparable efficacy to apixaban in the rabbit arteriovenous-shunt (AV) thrombosis model.