Detalles de la búsqueda
1.
Computational neurosciences and quantitative systems pharmacology: a powerful combination for supporting drug development in neurodegenerative diseases.
J Pharmacokinet Pharmacodyn
; 2023 Jul 28.
Artículo
Inglés
| MEDLINE | ID: mdl-37505397
2.
A quantitative systems pharmacology model for simulating OFF-Time in augmentation trials for Parkinson's disease: application to preladenant.
J Pharmacokinet Pharmacodyn
; 49(6): 593-606, 2022 12.
Artículo
Inglés
| MEDLINE | ID: mdl-36209447
3.
Learning from amyloid trials in Alzheimer's disease. A virtual patient analysis using a quantitative systems pharmacology approach.
Alzheimers Dement
; 16(6): 862-872, 2020 06.
Artículo
Inglés
| MEDLINE | ID: mdl-32255562
4.
Intelligent and effective informatic deconvolution of "Big Data" and its future impact on the quantitative nature of neurodegenerative disease therapy.
Alzheimers Dement
; 14(7): 961-975, 2018 07.
Artículo
Inglés
| MEDLINE | ID: mdl-29551332
5.
Knowledge-driven computational modeling in Alzheimer's disease research: Current state and future trends.
Alzheimers Dement
; 13(11): 1292-1302, 2017 Nov.
Artículo
Inglés
| MEDLINE | ID: mdl-28917669
6.
Big data to smart data in Alzheimer's disease: Real-world examples of advanced modeling and simulation.
Alzheimers Dement
; 12(9): 1022-1030, 2016 09.
Artículo
Inglés
| MEDLINE | ID: mdl-27327540
7.
Big data to smart data in Alzheimer's disease: The brain health modeling initiative to foster actionable knowledge.
Alzheimers Dement
; 12(9): 1014-1021, 2016 09.
Artículo
Inglés
| MEDLINE | ID: mdl-27238630
8.
Quantitative systems pharmacology-based exploration of relevant anti-amyloid therapy challenges in clinical practice.
Alzheimers Dement (N Y)
; 10(2): e12474, 2024.
Artículo
Inglés
| MEDLINE | ID: mdl-38774587
9.
Quantitative systems pharmacology as an extension of PK/PD modeling in CNS research and development.
J Pharmacokinet Pharmacodyn
; 40(3): 257-65, 2013 Jun.
Artículo
Inglés
| MEDLINE | ID: mdl-23338980
10.
Analysis of clinical failure of anti-tau and anti-synuclein antibodies in neurodegeneration using a quantitative systems pharmacology model.
Sci Rep
; 13(1): 14342, 2023 09 01.
Artículo
Inglés
| MEDLINE | ID: mdl-37658103
11.
A combined physiologically-based pharmacokinetic and quantitative systems pharmacology model for modeling amyloid aggregation in Alzheimer's disease.
CPT Pharmacometrics Syst Pharmacol
; 12(4): 444-461, 2023 04.
Artículo
Inglés
| MEDLINE | ID: mdl-36632701
12.
The future of Parkinson's disease research: A new paradigm of human-specific investigation is necessary and possible.
ALTEX
; 39(4): 694-709, 2022.
Artículo
Inglés
| MEDLINE | ID: mdl-35404466
13.
Hallmarks of neurodegenerative disease: A systems pharmacology perspective.
CPT Pharmacometrics Syst Pharmacol
; 11(11): 1399-1429, 2022 11.
Artículo
Inglés
| MEDLINE | ID: mdl-35894182
14.
Toward Predicting Impact of Common Genetic Variants on Schizophrenia Clinical Responses With Antipsychotics: A Quantitative System Pharmacology Study.
Front Neurosci
; 15: 738903, 2021.
Artículo
Inglés
| MEDLINE | ID: mdl-34658776
15.
Computational Approaches for Supporting Combination Therapy in the Post-Aducanumab Era in Alzheimer's Disease.
J Alzheimers Dis Rep
; 5(1): 815-826, 2021.
Artículo
Inglés
| MEDLINE | ID: mdl-34966890
16.
Exploring the relation between BOLD fMRI and cognitive performance using a computer-based quantitative systems pharmacology model: Applications to the COMTVAL158MET genotype and ketamine.
Eur Neuropsychopharmacol
; 50: 12-22, 2021 09.
Artículo
Inglés
| MEDLINE | ID: mdl-33951587
17.
Quantitative systems pharmacology in neuroscience: Novel methodologies and technologies.
CPT Pharmacometrics Syst Pharmacol
; 10(5): 412-419, 2021 05.
Artículo
Inglés
| MEDLINE | ID: mdl-33719204
18.
Simulating the Effects of Common Comedications and Genotypes on Alzheimer's Cognitive Trajectory Using a Quantitative Systems Pharmacology Approach.
J Alzheimers Dis
; 78(1): 413-424, 2020.
Artículo
Inglés
| MEDLINE | ID: mdl-33016912
19.
A modeling informed quantitative approach to salvage clinical trials interrupted due to COVID-19.
Alzheimers Dement (N Y)
; 6(1): e12053, 2020.
Artículo
Inglés
| MEDLINE | ID: mdl-33163611
20.
Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges.
CPT Pharmacometrics Syst Pharmacol
; 9(1): 5-20, 2020 01.
Artículo
Inglés
| MEDLINE | ID: mdl-31674729