Adsorptive and photocatalytic degradation potential of porous polymeric materials for removal of pesticides, pharmaceuticals, and dyes-based emerging contaminants from water.

Life on earth is dependent on clean water, which is crucial for survival. Water supplies are getting contaminated due to the growing human population and its associated industrialization, urbanization, and chemically improved agriculture. Currently, a large number of people struggle to find clean drinking water, a problem that is particularly serious in developing countries. To meet the enormous demand of clean water around the world, there is an urgent need of advanced technologies and materials that are affordable, easy to use, thermally efficient, portable, environmentally benign, and chemically durable. Physical, chemical and biological methods are used to eliminate insoluble materials and soluble pollutants from wastewater. In addition to cost, each treatment carries its limitations in terms of effectiveness, productivity, environmental effect, sludge generation, pre-treatment demands, operating difficulties, and the creation of potentially hazardous byproducts. To overcome the problems of traditional methods, porous polymers have distinguished themselves as practical and efficient materials for the treatment of wastewater because of their distinctive characteristics such as large surface area, chemical versatility, biodegradability, and biocompatibility. This study overviews improvement in manufacturing methods and the sustainable usage of porous polymers for wastewater treatment and explicitly discusses the efficiency of advanced porous polymeric materials for the removal of emerging pollutants viz. pesticides, dyes, and pharmaceuticals whereby adsorption and photocatalytic degradation are considered to be among the most promising methods for their effective removal. Porous polymers are considered excellent adsorbents for the mitigation of these pollutants as they are cost-effective and have greater porosities to facilitate penetration and adhesion of pollutants, thus enhance their adsorption functionality. Appropriately functionalized porous polymers can offer the potential to eliminate hazardous chemicals and making water useful for a variety of purposes thus, numerous types of porous polymers have been selected, discussed and compared especially in terms of their efficiencies against specific pollutants. The study also sheds light on numerous challenges faced by porous polymers in the removal of contaminants, their solutions and some associated toxicity issues.

Synthesis and characterization of Hyaluronic Acid (HA) modified polymeric composite for effective treatment of wound healing by transdermal drug delivery system (TDDS).

The present study aimed to fabricate a novel polymeric spongy composite to enhance skin regeneration composed of Nystatin (antifungal agent) and Silver Nanoparticles (AgNps). Different formulations (F1-F8) were developed & characterized by using various analytical techniques. AgNps synthesized by chemical reduction method showed spherical morphology 2 µm in size showed by SEM and XRD. A fine porous structure of gel embedded with AgNps having an amorphous structure with 10 % crystallinity due to AgNps was found. IR spectra revealed no chemical interaction between polymers and Nystatin. An increase in thermal stability of formulation was observed till 700 â„ƒ analyzed by Differential Scanning Calorimetry. Cytotoxic analysis on L929 mouse skin fibroblast cells showed a decrease in cell viability as Ag concentration increased (inactivating Fibroblast and keratinocytes) while 10 mg composition was found safest concentration (94%). Optimized formulation (F2) presented in-vitro drug release up to 90.59% ± 0.76 at pH 7.4, swelling studies (87.5% ± 0.57), water retention (26.60 ± 0.34), pH (5.31 ± 0.03). In the animal burn model, the group that received CHG/Ag/Nystatin healed the wound significantly (p < 0.05). These results suggested that optimized carrier can be used for other anti-fungal drugs facilitating the early healing of the wound.