Detalles de la búsqueda
1.
Multifunctional agents against Alzheimer's disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions.
Bioorg Med Chem
; 96: 117535, 2023 12 15.
Artículo
Inglés
| MEDLINE | ID: mdl-37956505
2.
Multitargeting Histamine H3 Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives.
Molecules
; 28(5)2023 Mar 03.
Artículo
Inglés
| MEDLINE | ID: mdl-36903593
3.
Serotonin 5-HT6 Receptor Ligands and Butyrylcholinesterase Inhibitors Displaying Antioxidant Activity-Design, Synthesis and Biological Evaluation of Multifunctional Agents against Alzheimer's Disease.
Int J Mol Sci
; 23(16)2022 Aug 21.
Artículo
Inglés
| MEDLINE | ID: mdl-36012707
4.
Benzophenone Derivatives with Histamine H3 Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease.
Molecules
; 28(1)2022 Dec 28.
Artículo
Inglés
| MEDLINE | ID: mdl-36615435
5.
Cyanobiphenyls: Novel H3 receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer's disease.
Bioorg Chem
; 114: 105129, 2021 09.
Artículo
Inglés
| MEDLINE | ID: mdl-34217977
6.
Biphenylalkoxyamine Derivatives-Histamine H3 Receptor Ligands with Butyrylcholinesterase Inhibitory Activity.
Molecules
; 26(12)2021 Jun 11.
Artículo
Inglés
| MEDLINE | ID: mdl-34208297
7.
Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease.
J Enzyme Inhib Med Chem
; 35(1): 1944-1952, 2020 Dec.
Artículo
Inglés
| MEDLINE | ID: mdl-33092411
8.
Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives-Anticancer and Cholinesterase-Inhibiting Activity.
Molecules
; 25(11)2020 Jun 03.
Artículo
Inglés
| MEDLINE | ID: mdl-32503288
9.
Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives.
Bioorg Chem
; 90: 103084, 2019 09.
Artículo
Inglés
| MEDLINE | ID: mdl-31271942
10.
Anti-Alzheimer's multitarget-directed ligands with serotonin 5-HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity.
Arch Pharm (Weinheim)
; 352(7): e1900041, 2019 Jul.
Artículo
Inglés
| MEDLINE | ID: mdl-31162703
11.
Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents.
Molecules
; 23(2)2018 Feb 07.
Artículo
Inglés
| MEDLINE | ID: mdl-29414887
12.
Lipophilic properties of anti-Alzheimer's agents determined by micellar electrokinetic chromatography and reversed-phase thin-layer chromatography.
Electrophoresis
; 38(9-10): 1268-1275, 2017 05.
Artículo
Inglés
| MEDLINE | ID: mdl-28169440
13.
Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta.
Molecules
; 21(4): 410, 2016 Mar 26.
Artículo
Inglés
| MEDLINE | ID: mdl-27023510
14.
Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease.
Molecules
; 21(5)2016 May 14.
Artículo
Inglés
| MEDLINE | ID: mdl-27187348
15.
4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H3 Receptors and Cholinesterases.
ACS Chem Neurosci
; 15(6): 1206-1218, 2024 Mar 20.
Artículo
Inglés
| MEDLINE | ID: mdl-38440987
16.
Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies.
Eur J Med Chem
; 249: 115135, 2023 Mar 05.
Artículo
Inglés
| MEDLINE | ID: mdl-36696766
17.
Guanidines: Synthesis of Novel Histamine H3R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect.
Pharmaceuticals (Basel)
; 16(5)2023 Apr 30.
Artículo
Inglés
| MEDLINE | ID: mdl-37242458
18.
Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, ß-secretase, and amyloid ß aggregation as potential treatment of Alzheimer's disease.
Eur J Med Chem
; 261: 115832, 2023 Dec 05.
Artículo
Inglés
| MEDLINE | ID: mdl-37837674
19.
Discovery of multifunctional anti-Alzheimer's agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters.
Eur J Med Chem
; 218: 113397, 2021 Jun 05.
Artículo
Inglés
| MEDLINE | ID: mdl-33838585
20.
Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with ß-amyloid anti-aggregation properties.
Eur J Med Chem
; 225: 113792, 2021 Dec 05.
Artículo
Inglés
| MEDLINE | ID: mdl-34530376