RESUMEN
We measured by the immunoenzyme assay serum levels of total IgE and leptin in 17 men and 95 women with non-alcoholic fatty liver diseases (NAFLD) and in 57 men and 25 women with alcoholic liver disease (ALD) in comparison with 454 control men and 74 women without hepatic pathology. It was shown that the total serum IgE level in patients with ALD (229.5 +/- 31.0 IU/l) is on the average twice that in NAFLD and control patients (89.7 +/- 15.0 and 96.2 +/- 16.0 IU/l respectively). The IgE level in patients with NAFLD is related to BMI and waist circumference (WC). Leptin levels in patients with NAFLD andALD are higher than in control and correlate with obesity signs in all three groups. They correlate with the IgE level and reach the maximum value at a concentration of total IgE over 100 IU/l in men with NAFLD and WC >94 and in women with BMI = >30.0 kg/m2 and WC >80 cm. Positive correlation between IgE, leptin level and obesity signs in men and women with NAFLD suggests that leptin may be a link between obesity, hepatosteatosis, and atopic diseases.
Asunto(s)
Hígado Graso Alcohólico/sangre , Inmunoglobulina E/sangre , Leptina/sangre , Enfermedad del Hígado Graso no Alcohólico/sangre , Obesidad/sangre , Adulto , Anciano , Anciano de 80 o más Años , Comorbilidad , Hígado Graso Alcohólico/epidemiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Enfermedad del Hígado Graso no Alcohólico/epidemiología , Obesidad/epidemiologíaRESUMEN
The study covers comparative analysis of silicosis course in males and females engaged into iron industry. Findings are more frequent combination of silicosis and chronic bronchitis in the females, without smoking habit. Some other differences in silicosis course and development were seen dependent on sex.
Asunto(s)
Contaminantes Ocupacionales del Aire/toxicidad , Polvo , Metalurgia , Cuarzo/toxicidad , Silicosis/diagnóstico , Femenino , Humanos , Masculino , Persona de Mediana Edad , Exposición Profesional/efectos adversos , Factores Sexuales , Silicosis/epidemiologíaRESUMEN
The levels of homocysteine (HC) and von Willebrand factor (VWF) as cardiovascular risk factors were studied in patients with Stage II chronic alcoholism. Forty-one men with Stage II chronic alcoholism without clinical signs of somatic and infectious diseases were examined. Their median age was 37 (range 32-40) years; the alcoholization period was 12 (range 8-17) years. Plasma HC and VWF (amount and activity) levels were determined. In 63.4% of chronic alcoholic patients, HC levels was twice as high as in the controls; in 80.6%, both the content and activity of VWF were increased. There was no correlation between the levels of HC and VWF. Vascular endothelial damage concurrent with hyperhomocysteinemia increases a cardiovascular risk in patients with Stage II chronic alcoholism.
Asunto(s)
Alcoholismo/sangre , Homocisteína/sangre , Factor de von Willebrand/metabolismo , Adulto , Alcoholismo/complicaciones , Enfermedades Cardiovasculares/sangre , Enfermedades Cardiovasculares/etiología , Humanos , Masculino , Factores de RiesgoRESUMEN
The studies covered hemostasis changes in workers with occupational fluorosis. The disorders diagnosed could be a risk factor for IHD in aluminium production workers
Asunto(s)
Flúor/envenenamiento , Hemostasis/fisiología , Isquemia Miocárdica/etiología , Enfermedades Profesionales/sangre , Exposición Profesional/efectos adversos , Aluminio , Hemostasis/efectos de los fármacos , Humanos , Metalurgia , Isquemia Miocárdica/sangre , Enfermedades Profesionales/inducido químicamente , Enfermedades Profesionales/complicaciones , Factores de RiesgoRESUMEN
The authors analyzed the causes of death in patients with chronic alcoholism over the period of three years. The findings obtained show that the most frequent causes of mortality include injuries and accidents, suicides and acute alcohol intoxication. It was revealed that with the increasing duration of alcoholism there was a decrease in the proportion of the mortality rate from the mentioned factors whereas the mortality incidence secondary to somatic disease increased. In patients who had suffered alcoholic psychoses, the suicide-associated mortality occurred two times more frequently which is explained by more severe disorders of the social and psychological personality adaptation.
Asunto(s)
Alcoholismo/mortalidad , Adulto , Factores de Edad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores SexualesRESUMEN
The study was made of marker distribution of 17 hereditary polymorphism systems in 493 patients with myocardial infarction (MI) and 422 healthy subjects. The prognostic system for determination of predisposition or resistance to MI development has been designed in accordance with marker occurrence in the patients and healthy subjects basing on Bayer's method. When the sum of the prognostic ratios of all the markers is +5 scores and more there is a high risk of MI, when this sum is -6 scores and less the resistance to its genesis is predicted. The proposed prognostic system makes it possible to predict predisposition to myocardial infarction at an early age and, therefore, to take preventive measures.
Asunto(s)
Infarto del Miocardio/diagnóstico , Adulto , Antígenos de Grupos Sanguíneos/genética , Distribución de Chi-Cuadrado , Susceptibilidad a Enfermedades , Femenino , Marcadores Genéticos , Humanos , Masculino , Persona de Mediana Edad , Infarto del Miocardio/sangre , Infarto del Miocardio/genética , Fenotipo , Probabilidad , Pronóstico , Factores de RiesgoRESUMEN
The course of the postmyocardial infarction period was studied in 452 patients with previously determined genetic markers of 18 genetic polymorphic systems. Clinical and genetic factors related to an unfavourable course of the disease in male and female patients with myocardial infarction were identified. The data obtained enable development of the systems for long-term prognostication of the high risk of an unfavourable course of a 10-year postmyocardial infarction period.
Asunto(s)
Infarto del Miocardio/diagnóstico , Infarto del Miocardio/genética , Anciano , Anciano de 80 o más Años , Femenino , Marcadores Genéticos , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Calidad de Vida , Factores de TiempoRESUMEN
The effectiveness and safety of therapy with nebivolol and its effects on life quality (LQ) were studied in 71 patients with prior myocardial infarction (MI) with an ejection fraction of 40% or more. The follow-up lasted 1 year. The mean daily dose of the drug was 3.66 +/- 0.11 mg. Echocardiography, bicycle ergometry, daily ECG monitoring, survey according to the questionnaires developed by V. P. Zaitsev, a researcher of All-Russian Cardiology Research Center, Russian Academy of Medical Sciences, to the depression scale (DS), the personality scale (PS) and reactive anxiety scale (RAS) by Spilberg-Khanin were performed. The study was conducted on the day of initiation of outpatient treatment, following 3 months and 1 year. After 3 months of therapy, clinical improvement was observed in 83% of the patients and it preserved at the same level till the end of the first year: exercise tolerance and the total volume of work increased significantly (p < 0.001), 97% of the examinees returned to work. Nebivolol produced an antiarrhythmic effect in 66.7% of the patients with high Lown gradation premature beats. Therapy with the agent showed a low mortality rates (1.4%), few number of cardiovascular excesses (4.2%), and good tolerability (7.2%). By the end of the first year, cardiac remodeling improved insignificantly: end-systolic volume, end-diastolic volume, left ventricular myocardial mass decreased by 6.4, 1.4, and 7%, respectively; fraction ejection increased by 2.3% of the baseline values. The parameters of LQ improved: the RAS scores reduced by 18.4%; the number of patients with high PS scores decreased significantly (p < 0.05) due to the increase in the number of patients with its moderate level (p < 0.01) and, what is significant, erectile function did not deteriorate. Thus, nebivolol demonstrated its high effectiveness and safety during prolonged therapy of patients with prior MI, without cardiodepressive activity and favorable impact on their LQ.
Asunto(s)
Antagonistas Adrenérgicos beta/uso terapéutico , Antihipertensivos/uso terapéutico , Benzopiranos/uso terapéutico , Etanolaminas/uso terapéutico , Infarto del Miocardio/tratamiento farmacológico , Antagonistas Adrenérgicos beta/administración & dosificación , Adulto , Antihipertensivos/administración & dosificación , Benzopiranos/administración & dosificación , Electrocardiografía , Etanolaminas/administración & dosificación , Prueba de Esfuerzo , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Nebivolol , Calidad de Vida , Encuestas y Cuestionarios , Factores de Tiempo , Resultado del TratamientoRESUMEN
The incidence of ischemic heart disease (IHD) and risk factors of its genesis have been studied in 380 miners of a control group non-exposed to industrial vibration. Constitution type and a number of phenotypic signs have been determined for all examined workers with hemostatic indices defined in 60 miners before and after the performance of vibrational load test. High incidence of IHD, arterial hypertension and hyperholesterolemia have been detected in the miners working with vibration instruments and hemostatic disorders predisposing to ischemic heart disease have been revealed. In the miners of vibrodangerous occupations suffering from ischemic heart disease, hypersthenic constitution type determined by Rees-Eysenc index less than 92.2 and the height below 170 cm was found to occur more frequently.
Asunto(s)
Minería , Isquemia Miocárdica/etiología , Enfermedades Profesionales/etiología , Vibración/efectos adversos , Adulto , Anciano , Áreas de Influencia de Salud , Humanos , Masculino , Persona de Mediana Edad , Isquemia Miocárdica/epidemiología , Enfermedades Profesionales/epidemiología , Federación de Rusia/epidemiologíaRESUMEN
Platelet hemostasis was studied in 23 patients with chronic alcoholism (CA) stage II at rest and under muscular exercise. At rest, the patients had elevated spontaneous aggregation of platelets and more active start of adrenaline and ristomycin aggregation. Exercise stimulated spontaneous platelet aggregation, enhances adrenaline and ristomycin aggregation. According to adrenalin test 32% of the examinees had platelet dysfunction. According to ristomycin aggregation, vascular endothelium was impaired in 95.7%of the patients. Thus, it is evident that CA stage II patients develop disorder of platelet hemostasis and vascular endothelium. Such patients are at high risk of thrombogenesis.
Asunto(s)
Alcoholismo/sangre , Ejercicio Físico/fisiología , Hemostasis/fisiología , Agregación Plaquetaria/fisiología , Descanso/fisiología , Adulto , Antibacterianos , Enfermedad Crónica , Epinefrina , Prueba de Esfuerzo , Humanos , Masculino , Ristocetina , Índice de Severidad de la Enfermedad , VasoconstrictoresRESUMEN
Studies covered incidence of coronary heart disease, its risk factors and features of constitutional types among Kouzbass coal miners suffering from anthracosilicosis and chronic dust bronchitis. Findings are reliably higher incidence of coronary heart disease among coal miners having lung diseases caused by dust. Coronary heart disease among the miners with anthracosilicosis is favored by arterial hypertension, overweight and hypersthenic constitutional type, that among those with dust bronchitis is favored only by overweight.
Asunto(s)
Minas de Carbón , Polvo , Enfermedades Pulmonares/etiología , Isquemia Miocárdica/epidemiología , Enfermedades Profesionales/epidemiología , Trastornos Somatomorfos/epidemiología , Adulto , Anciano , Áreas de Influencia de Salud , Enfermedad Crónica , Femenino , Humanos , Enfermedades Pulmonares/epidemiología , Masculino , Persona de Mediana Edad , Isquemia Miocárdica/etiología , Factores de Riesgo , Federación de Rusia/epidemiologíaRESUMEN
Occurrence of coronary heart disease and its risk factors are studied in individuals working with vibration instruments--in drift miners, miners of breakage face--and in 390 reference group miners who never faced occupational vibration. Findings are higher incidence of coronary heart disease, arterial hypertension and hypercholesterole mia in the miners working with vibration instruments. The main group miners suffering from coronary heart disease demonstrated more frequent hypersthenic constitutional type.
Asunto(s)
Constitución Corporal , Minas de Carbón , Isquemia Miocárdica/etiología , Enfermedades Profesionales/etiología , Vibración/efectos adversos , Humanos , Isquemia Miocárdica/diagnóstico , Isquemia Miocárdica/epidemiología , Enfermedades Profesionales/diagnóstico , Enfermedades Profesionales/epidemiologíaRESUMEN
Examination of 15 systems of hereditary polymorphism including HLA system was conducted in 284 patients suffering from silicosis and 431 healthy subjects. The results provided genetic factors showing propensity to and resistance against silicosis. The data served as a base for silicosis risk groups formation among the staffers at occupational risk of silicosis, for occupational selection during placement to enterprises with silicosis danger.
Asunto(s)
Silicosis/genética , Susceptibilidad a Enfermedades , Antígenos HLA , Humanos , Inmunidad Innata , Fenotipo , Polimorfismo Genético , Factores de Riesgo , Silicosis/etiologíaRESUMEN
Chronic bronchitis frequently accompanies silicosis in metallurgy workers. Association of the two diseases significantly lowers life quality and disables the patients. Prophylactic measures for the diseases are elimination of the etiologic factors and detection of genetic markers for propensity and insusceptibility to silicosis and chronic bronchitis. Phenotypes of Lewis a-b- system, of Hp2-1 haptoglobin and of group-specific component Gc2-2 could be risk factors for chronic bronchitis in silicosis patients. Those of Lewis a-b+ system, of Hp2-2 haptoglobin and group-specific component Gc1-2 are resistant to chronic bronchitis on silicosis background.