RESUMEN
Postural stability can be threatened by the low-frequency motions in transport that are usually quantified by their root-mean-square (r.m.s.) acceleration. This study investigated how the stability of walking people depends on the waveform of 1- and 2-Hz mediolateral oscillations of the surface on which they walk. Walking on a treadmill, 20 subjects were perturbed by random oscillations of the treadmill with one-third octave bandwidths: different waveforms with the same r.m.s. acceleration and different waveforms with the same peak acceleration. Stability was measured subjectively and objectively by the velocity of the center of pressure in the mediolateral direction. Subjective and objective measures of walking instability increased with increasing r.m.s. acceleration of oscillations having the same peak acceleration. These same measures of instability were also affected by the peak acceleration when the r.m.s. magnitude of the oscillations was constant, especially with 1-Hz oscillations. It is concluded that r.m.s. measures of acceleration are insufficient to predict the postural stability of walking passengers exposed to mediolateral oscillations and that peaks in the oscillations should also be taken into account.
Asunto(s)
Equilibrio Postural , Caminata/fisiología , Aceleración , Adulto , Fenómenos Biomecánicos , Prueba de Esfuerzo , Humanos , Masculino , Movimiento (Física)RESUMEN
BACKGROUND: Thermotactile thresholds and vibrotactile thresholds are measured to assist the diagnosis of the sensorineural component of the hand-arm vibration syndrome (HAVS). OBJECTIVES: This study investigates whether thermotactile and vibrotactile thresholds distinguish between fingers with and without numbness and tingling. METHODS: In 60 males reporting symptoms of the hand-arm vibration syndrome, thermotactile thresholds for detecting hot and cold temperatures and vibrotactile thresholds at 31.5 and 125 Hz were measured on the index and little fingers of both hands. RESULTS: In fingers reported to suffer numbness or tingling, hot thresholds increased, cold thresholds decreased, and vibrotactile thresholds at both 31.5 and 125 Hz increased. With sensorineural symptoms on all three phalanges (i.e. numbness or tingling scores of 6), both thermotactile thresholds and both vibrotactile thresholds had sensitivities greater than 80% and specificities around 90%, with areas under the receiver operating characteristic curves around 0.9. There were correlations between all four thresholds, but cold thresholds had greater sensitivity and greater specificity on fingers with numbness or tingling on only the distal phalanx (i.e. numbness or tingling scores of 1) suggesting cold thresholds provide better indications of early sensorineural disorder. CONCLUSIONS: Thermotactile thresholds and vibrotactile thresholds can provide useful indications of sensorineural function in patients reporting symptoms of the sensorineural component of HAVS.
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Síndrome por Vibración de la Mano y el Brazo/diagnóstico , Mecanorreceptores/patología , Umbral Sensorial/fisiología , Termorreceptores/fisiopatología , Adulto , Anciano , Dedos/fisiopatología , Síndrome por Vibración de la Mano y el Brazo/fisiopatología , Humanos , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/diagnóstico , Temperatura , VibraciónRESUMEN
Standards assume vibration discomfort depends on the frequency and direction of whole-body vibration, with the same weightings for frequency and direction at all magnitudes. This study determined equivalent comfort contours from 1.0 to 10 Hz in each of three directions (fore-and-aft, lateral, vertical) at magnitudes in the range 0.1 to 3.5 ms-2 r.m.s. Twenty-four subjects sat on a rigid flat seat with and without a beanbag, altering the pressure distribution on the seat but not the transmission of vibration. The rate of growth of vibration discomfort with increasing magnitude of vibration differed between the directions of vibration and varied with the frequency of vibration. The frequency-dependence and direction-dependence of discomfort, therefore, depended on the magnitude of vibration. The beanbag did not affect the frequency-dependence or direction-dependence of vibration discomfort. It is concluded that different weightings for the frequency and direction of vibration are required for low and high magnitude vibration. Practitioner summary: When evaluating whole-body vibration to predict vibration discomfort, the weightings appropriate to different frequencies and different directions of vibration should depend on the magnitude of vibration. This is overlooked in all current methods of evaluating the severity of whole-body vibration.
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Ergonomía , Vibración/efectos adversos , Adulto , Femenino , Humanos , Masculino , Adulto JovenRESUMEN
This study investigated effects of applied force on the apparent mass of the hand, the dynamic stiffness of glove materials and the transmission of vibration through gloves to the hand. For 10 subjects, 3 glove materials and 3 contact forces, apparent masses and glove transmissibilities were measured at the palm and at a finger at frequencies in the range 5-300 Hz. The dynamic stiffnesses of the materials were also measured. With increasing force, the dynamic stiffnesses of the materials increased, the apparent mass at the palm increased at frequencies greater than the resonance and the apparent mass at the finger increased at low frequencies. The effects of force on transmissibilities therefore differed between materials and depended on vibration frequency, but changes in apparent mass and dynamic stiffness had predictable effects on material transmissibility. Depending on the glove material, the transmission of vibration through a glove can be increased or decreased when increasing the applied force. Practitioner summary: Increasing the contact force (i.e. push force or grip force) can increase or decrease the transmission of vibration through a glove. The vibration transmissibilities of gloves should be assessed with a range of contact forces to understand their likely influence on the exposure of the hand and fingers to vibration.
Asunto(s)
Guantes Protectores , Mano/fisiología , Vibración , Adulto , Fenómenos Biomecánicos , Femenino , Dedos , Geles , Fuerza de la Mano , Humanos , Masculino , Ensayo de Materiales/métodos , Fenómenos Mecánicos , Adulto JovenRESUMEN
The frequency content of a mechanical shock is not confined to its fundamental frequency, so it was hypothesised that the frequency-dependence of discomfort caused by shocks with defined fundamental frequencies will differ from the frequency-dependence of sinusoidal vibration. Subjects experienced vertical vibration and vertical shocks with fundamental frequencies from 0.5 to 16 Hz and magnitudes from ±0.7 to ±9.5 ms-2. The rate of growth of discomfort with increasing magnitude of motion decreased with increasing frequency of both motions, so the frequency-dependence of discomfort varied with the magnitudes of both motions and no single frequency weighting will be ideal for all magnitudes. At the frequencies of sinusoidal vibration producing greatest discomfort (4-16 Hz), shocks produced less discomfort than vibration with same peak acceleration or unweighted vibration dose value. Frequency-weighted vibration dose values provided the best predictions of the discomfort caused by different frequencies and magnitudes of vibration and shock. Practitioner Summary: Human responses to vibration and shock vary according to the frequency content of the motion. The ideal frequency weighting depends on the magnitude of the motion. Standardised frequency-weighted vibration dose values estimate discomfort caused by vibration and shock but for motions containing very low frequencies the filtering is not optimum.
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Aceleración/efectos adversos , Movimiento (Física) , Postura/fisiología , Vibración/efectos adversos , Adulto , Fenómenos Biomecánicos , Humanos , Masculino , Adulto JovenRESUMEN
PURPOSE: This study investigates the effects of room temperature on two standard tests used to assist the diagnosis of vibration-induced white finger (VWF): finger rewarming times and finger systolic blood pressures. METHODS: Twelve healthy males and twelve healthy females participated in four sessions to obtain either finger skin temperatures (FSTs) during cooling and rewarming of the hand or finger systolic blood pressures (FSBPs) after local cooling of the fingers to 15 and 10 °C. The measures were obtained with the room temperature at either 20 or 28 °C. RESULTS: There were lower baseline finger skin temperatures, longer finger rewarming times, and lower finger systolic blood pressures with the room temperature at 20 than 28 °C. However, percentage reductions in FSBP at 15 and 10 °C relative to 30 °C (i.e. %FSBP) did not differ between the two room temperatures. Females had lower baseline FSTs, longer rewarming times, and lower FSBPs than males, but %FSBPs were similar in males and females. CONCLUSIONS: Finger rewarming times after cold provocation are heavily influenced by room temperature and gender. For evaluating peripheral circulatory function using finger rewarming times, the room temperature must be strictly controlled, and a different diagnostic criterion is required for females. The calculation of percentage changes in finger systolic blood pressure at 15 and 10 °C relative to 30 °C reduces effects of both room temperature and gender, and the test may be used in conditions where the ±1 °C tolerance on room temperature required by the current standard cannot be achieved.
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Frío , Dedos/fisiología , Síndrome por Vibración de la Mano y el Brazo/diagnóstico , Recalentamiento , Temperatura Cutánea/fisiología , Adulto , Presión Sanguínea , Femenino , Humanos , Masculino , Enfermedades Profesionales/diagnóstico , Pletismografía , Factores Sexuales , Temperatura , Adulto JovenRESUMEN
The biodynamic response of the seated human body has been investigated with 20 males exposed to upward and downward shocks at 13 fundamental frequencies (1-16 Hz) and 18 magnitudes (up to ±8.3 ms-2). For 1- and 2- degree-of-freedom models, the stiffness and damping coefficients were obtained by fitting seat acceleration waveforms predicted from the measured force to the measured seat acceleration waveform. Stiffness and damping coefficients were also obtained in the frequency domain with random vibration. The optimum stiffness and damping coefficients varied with the magnitude and the frequency of shocks. With both upward and downward shocks, the resonance frequency of the models decreased from 6.3 to 4 Hz as the vibration dose values of the shocks increased from 0.05 to 2.0 ms-1.75. The stiffness and damping obtained from responses to shocks were correlated with, and similar to, the stiffness and damping obtained with random vibration. Practitioner Summary: When modelling the dynamic response of the seated human body to vertical acceleration less than 1 g, the relation between force and acceleration can be well represented by a single degree-of-freedom model although the optimum stiffness and damping depend on the magnitude and frequency of sinusoidal, random or shock motion.
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Aceleración , Movimiento (Física) , Postura , Vibración , Adulto , Fenómenos Biomecánicos , Humanos , Masculino , Adulto JovenRESUMEN
For three samples of material (12.5, 25.0 and 37.5 mm diameter) from each of three gloves, the dynamic stiffnesses and the vibration transmissibilities of the materials (to both the palm of the hand and the thenar eminence) were measured at frequencies from 10 to 300 Hz. Additional measurements showed the apparent masses of the hand at the palm and the thenar eminence were independent of contact area at frequencies less than about 40 Hz, but increased with increasing area at higher frequencies. The stiffness and damping of the glove materials increased with increasing area. These changes caused material transmissibilities to the hand to increase with increasing area. It is concluded that the size of the area of contact has a large influence on the transmission of vibration through a glove to the hand. The area of contact should be well-defined and controlled when evaluating the transmission of vibration through gloves. Practitioner Summary: The transmission of vibration through gloves depends on both the dynamic stiffness of glove material and the dynamic response of the hand. Both of these depend on the size of the contact area between a glove material and the hand, which should be taken into account when assessing glove transmissibility.
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Guantes Protectores , Mano , Ensayo de Materiales , Vibración , Adulto , Impedancia Eléctrica , Humanos , Masculino , Adulto JovenRESUMEN
The frequency dependence of discomfort caused by vertical mechanical shocks has been investigated with 20 seated males exposed to upward and downward shocks at 13 fundamental frequencies (1-16 Hz) and 18 magnitudes (±0.12 to ±8.3 ms-2). The rate of growth of discomfort with increasing shock magnitude depended on the fundamental frequency of the shocks, so the frequency dependence of equivalent comfort contours (for both vertical acceleration and vertical force measured at the seat) varied with shock magnitude. The rate of growth of discomfort was similar for acceleration and force, upward and downward shocks, and lower and higher magnitude shocks. The frequency dependence of discomfort from shocks differs from that of sinusoidal vibrations having the same fundamental frequencies. This arises in part from the frequency content of the shock. Frequency weighting Wb in BS 6841:1987 and ISO 2631-1:1997 provided reasonable estimates of the discomfort caused by the shocks investigated in this study. Practitioner Summary: No single frequency weighting can accurately predict the discomfort caused by mechanical shocks over wide ranges of shock magnitude, but vibration dose values with frequency weighting Wb provide reasonable estimates of discomfort caused by shocks similar to those investigated in this study with peak accelerations well below 1 g.
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Aceleración , Postura , Vibración , Adulto , Fenómenos Biomecánicos , Humanos , Masculino , Adulto JovenRESUMEN
AIMS/HYPOTHESIS: The effect of n-3 fatty acid treatment on temperature perception as a sensory nerve function modality is uncertain. In patients with non-alcoholic fatty liver disease (NAFLD) both with and without type 2 diabetes, we: (1) tested whether 15-18 months' treatment with 4 g/day of docosahexaenoic plus eicosapentaenoic acid (DHA+EPA) improved hot (HPT) and cold (CPT) temperature perception thresholds and (2) explored factors associated with HPT and CPT, in a randomised, double-blind, placebo-controlled trial. METHODS: The effect of treatment (n = 44) on HPT, CPT and temperature perception index (TPI: difference between HPT and CPT) was measured at the big toe in 90 individuals without neuropathy (type 2 diabetes; n = 30). Participants were randomised 1:1, using sequential numbering, by personnel independent from the trial team. All participants and all members of the research team were blinded to group assignment. Data were collected in the Southampton National Institute for Health Research Biomedical Research Centre. Treatment effects and the independence of associations were testing by regression modelling. RESULTS: Mean ± SD age was 50.9 ± 10.6 years. In men (n = 53) and women (n = 37), HPTs (°C) were 46.1 ± 5.1 and 43.1 ± 6.4 (p = 0.02), CPTs (°C) were 22.7 ± 3.4 and 24.5 ± 3.6 (p = 0.07) and TPIs (°C) were 23.4 ± 7.4 and 18.7 ± 9.5 (p = 0.008), respectively. In univariate analyses, total body fat percentage (measured by dual-energy x-ray absorptiometry [DXA]) was associated with HPT (r = -0.36 p = 0.001), CPT (r = 0.35 p = 0.001) and TPI (r = 0.39 p = 0.0001). In multivariable-adjusted regression models, adjusting for age, sex and other potential confounders, only body fat percentage was independently associated with HPT, CPT or TPI (p = 0.006, p = 0.006 and p = 0.002, respectively). DHA+EPA treatment did not modify HPT, CPT or TPI (p = 0.93, p = 0.44 and p = 0.67, respectively). There were no important adverse effects or side effects reported. CONCLUSIONS/INTERPRETATION: Higher body fat percentage is associated with enhanced temperature perception. There was no benefit of treatment with high-dose n-3 fatty acids on the thresholds to detect hot or cold stimuli. TRIAL REGISTRATION: ClinicalTrials.gov NCT00760513 FUNDING: This work was supported by the National Institute for Health Research through the NIHR Southampton Biomedical Research Unit grant and by a Diabetes UK allied health research training fellowship awarded to KMcC (Diabetes UK. BDA 09/0003937).
Asunto(s)
Hígado Graso/fisiopatología , Enfermedad del Hígado Graso no Alcohólico/fisiopatología , Temperatura , Adulto , Sistema Cardiovascular/metabolismo , Diabetes Mellitus Tipo 2/fisiopatología , Ácidos Docosahexaenoicos/farmacología , Método Doble Ciego , Combinación de Medicamentos , Ácido Eicosapentaenoico/farmacología , Hígado Graso/metabolismo , Femenino , Humanos , Resistencia a la Insulina , Masculino , Microcirculación/efectos de los fármacos , Persona de Mediana EdadRESUMEN
BACKGROUND: Vibration-induced white finger (VWF) is the vascular component of the hand-arm vibration syndrome (HAVS). Two tests have been standardised so as to assist the diagnosis of VWF: the measurement of finger rewarming times and the measurement of finger systolic blood pressures (FSBPs). OBJECTIVES: This study investigates whether the two tests distinguish between fingers with and without symptoms of whiteness and compares individual results between the two test methods. METHODS: In 60 men reporting symptoms of the HAVS, the times for their fingers to rewarm by 4°C (after immersion in 15°C water for 5â min) and FSBPs at 30°C, 15°C and 10°C were measured on the same day. RESULTS: There were significant increases in finger rewarming times and significant reductions in FSBPs at both 15°C and 10°C in fingers reported to suffer blanching. The FSBPs had sensitivities and specificities >90%, whereas the finger rewarming test had a sensitivity of 77% and a specificity of 79%. Fingers having longer rewarming times had lower FSBPs at both temperatures. CONCLUSIONS: The findings suggest that, when the test conditions are controlled according to the relevant standard, finger rewarming times and FSBPs can provide useful information for the diagnosis of VWF, although FSBPs are more sensitive and more specific.
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Dedos/irrigación sanguínea , Síndrome por Vibración de la Mano y el Brazo/diagnóstico , Enfermedades Profesionales/diagnóstico , Adulto , Anciano , Presión Sanguínea , Frío , Dedos/fisiopatología , Humanos , Masculino , Persona de Mediana Edad , Pletismografía , Curva ROC , Sensibilidad y Especificidad , Factores de TiempoRESUMEN
PURPOSE: This study investigated whether the reductions in finger blood flow induced by 125-Hz vibration applied to different locations on the hand depend on thresholds for perceiving vibration at these locations. METHODS: Subjects attended three sessions during which vibration was applied to the right index finger, the right thenar eminence, or the left thenar eminence. Absolute thresholds for perceiving vibration at these locations were determined. Finger blood flow in the middle finger of both hands was then measured at 30-s intervals during five successive 5-min periods: (i) pre-exposure, (ii) pre-exposure with 2-N force, (iii) 2-N force with vibration, (iv) post-exposure with 2-N force, (v) recovery. During period (iii), vibration was applied at 15 dB above the absolute threshold for perceiving vibration at the right thenar eminence. RESULTS: Vibration at all three locations reduced finger blood flow on the exposed and unexposed hand, with greater reductions when vibrating the finger. Vibration-induced vasoconstriction was greatest for individuals with low thresholds and locations of excitation with low thresholds. CONCLUSIONS: Differences in vasoconstriction between subjects and between locations are consistent with the Pacinian channel mediating both absolute thresholds and vibration-induced vasoconstriction.
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Dedos/irrigación sanguínea , Vasoconstricción , Vibración/efectos adversos , Adulto , Dedos/fisiopatología , Mano , Síndrome por Vibración de la Mano y el Brazo/etiología , Síndrome por Vibración de la Mano y el Brazo/fisiopatología , Voluntarios Sanos , Humanos , Masculino , Flujo Sanguíneo Regional , Umbral Sensorial , Adulto JovenRESUMEN
It might be assumed that increasing the thickness of a glove would reduce the vibration transmitted to the hand. Three material samples from an anti-vibration glove were stacked to produce three thicknesses: 6.4, 12.8 and 19.2 mm. The dynamic stiffnesses of all three thicknesses, the apparent mass at the palm and the finger and the transmission of vibration to the palm and finger were measured. At frequencies from 20 to 350 Hz, the material reduced vibration at the palm but increased vibration at the finger. Increased thickness reduced vibration at the palm but increased vibration at the finger. The measured transmissibilities could be predicted from the material dynamic stiffness and the apparent mass of the palm and finger. Reducing the dynamic stiffness of glove material may increase or decrease the transmission of vibration, depending on the material, the frequency of vibration and the location of measurement (palm or finger). Practitioner Summary: Transmission of vibration through gloves depends on the dynamic response of the hand and the dynamic stiffness of glove material, which depends on material thickness. Measuring the transmission of vibration through gloves to the palm of the hand gives a misleading indication of the transmission of vibration to the fingers.
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Exposición a Riesgos Ambientales , Guantes Protectores , Ensayo de Materiales/métodos , Vibración/efectos adversos , Fenómenos Biomecánicos , Exposición a Riesgos Ambientales/efectos adversos , Exposición a Riesgos Ambientales/prevención & control , Dedos/fisiología , Guantes Protectores/clasificación , Guantes Protectores/normas , Mano/fisiología , Humanos , Estrés FisiológicoRESUMEN
AIMS/HYPOTHESIS: The effect of n-3 fatty acid treatment on vibration perception thresholds (VPTs) and cutaneous microvascular reactivity is not known. We tested whether: (1) a 15-18 month treatment with high dose (4 g/day) docosahexaenoic (DHA) plus eicosapentaenoic (EPA) acid improved VPT and microvascular reactivity in patients with non-alcoholic fatty liver disease; and (2) there are associations between VPT, microvascular reactivity and metabolic variables. METHODS: In the completed single centre, randomised, parallel group, placebo controlled Wessex Evaluation of fatty Liver and Cardiovascular markers in non-alcoholic fatty liver disease with OMacor thErapy (WELCOME) trial, we tested the effect of DHA+EPA on VPT at 125 Hz (big toe) and the cutaneous hyperaemic response (forearm) to arterial occlusion (ratio of maximum to resting blood flux [MF/RF]). Allocation and dispensing was carried out by an independent research pharmacist; all participants and research team members were blinded to group assignment. RESULTS: In all, 51 and 49 patients were randomised to placebo and DHA+EPA, respectively (mean age 51.4 years). Of these, 32 had type 2 diabetes. Forty-six (placebo) and 47 (DHA+EPA) patients completed the study; there were no important adverse (or unexpected) effects or side effects. In multivariable-adjusted regression models (intention-to-treat analyses), DHA+EPA treatment was associated with an increase in VPT (ß coefficient 1.49 [95% CI 0.04, 2.94], p = 0.04). For VPT, the adjusted mean differences (95% CIs) in the placebo and DHA+EPA treatment groups were -0.725 (-1.71, 0.25) and 0.767 (-0.21, 1.75) m/s(2), respectively. With DHA+EPA treatment, there was no change in MF/RF (ß coefficient 0.07 [95% CI -0.56, 0.70], p = 0.84), the adjusted mean differences (95% CIs) in the placebo and DHA+EPA treatment groups were -0.549 (-1.03, -0.07) and -0.295 (-0.77, 0.18) respectively. VPT was independently associated with age (ß coefficient 0.019 [95% CI 0.010, 0.029], p < 0.0001) and MF/RF (ß coefficient -0.074 [95% CI -0.132, -0.016], p = 0.013), but not with diabetes (p = 0.38). CONCLUSIONS/INTERPRETATION: High dose n-3 fatty acid treatment did not improve measures of microvascular function or vibration perception. Ageing and microvascular reactivity are associated with a measure of peripheral nerve function. TRIAL REGISTRATION: ClinicalTrials.gov NCT00760513. FUNDING: The study was funded by the National Institute for Health Research UK and Diabetes UK.
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Ácidos Grasos Omega-3/farmacología , Microvasos/efectos de los fármacos , Enfermedad del Hígado Graso no Alcohólico/fisiopatología , Percepción del Tacto/efectos de los fármacos , Vibración , Adulto , Anciano , Diabetes Mellitus Tipo 2/complicaciones , Diabetes Mellitus Tipo 2/fisiopatología , Suplementos Dietéticos , Femenino , Humanos , Masculino , Microvasos/fisiopatología , Persona de Mediana Edad , Enfermedad del Hígado Graso no Alcohólico/complicacionesRESUMEN
While there has been significant progress in determining the transcriptional cascade involved in terminal adipocyte differentiation, less is known about early events leading to lineage commitment and cell fate choice. It has been recently discovered that zinc finger protein 423 (Zfp423) is an early actor in adipose determination. Here, we show that a close paralog of Zfp423, Zfp521, acts as a key regulator of adipose commitment and differentiation in vitro and in vivo. Zfp521 exerts its actions by binding to early B cell factor 1 (Ebf1), a transcription factor required for the generation of adipocyte progenitors, and inhibiting the expression of Zfp423. Overexpression of Zfp521 in cells greatly inhibits adipogenic potential, whereas RNAi-mediated knock-down or genetic ablation of Zfp521 enhances differentiation. In addition, Zfp521â»/â» embryos exhibit increased mass of interscapular brown adipose tissue and subcutaneous white adipocytes, a cell autonomous effect. Finally, Ebf1 participates in a negative feedback loop to repress Zfp521 as differentiation proceeds. Because Zfp521 is known to promote bone development, our results suggest that it acts as a critical switch in the commitment decision between the adipogenic and osteogenic lineages.
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Adipocitos/citología , Adipogénesis , Tejido Adiposo/citología , Regulación del Desarrollo de la Expresión Génica , Factores de Transcripción/metabolismo , Células 3T3 , Adipocitos/metabolismo , Tejido Adiposo/metabolismo , Animales , Proteínas de Unión al ADN/genética , Proteínas de Unión al ADN/metabolismo , Embrión de Mamíferos/citología , Embrión de Mamíferos/metabolismo , Desarrollo Embrionario , Técnicas de Silenciamiento del Gen , Células HeLa , Humanos , Inmunoprecipitación , Masculino , Ratones , Ratones Desnudos , Unión Proteica , Mapeo de Interacción de Proteínas , Proteínas Represoras/genética , Proteínas Represoras/metabolismo , Transactivadores/genética , Transactivadores/metabolismo , Factores de Transcripción/genética , Activación TranscripcionalRESUMEN
OBJECTIVES: This study investigated the effect of hand elevation on reductions in finger blood flow (FBF) induced by hand-transmitted vibration. METHODS: Fourteen males attended six sessions on six separate days, with a control sessions and a vibration session (125-Hz vibration at 44 ms(-2) rms) with the right hand supported at each of three elevations: 20 cm below heart level (HL), at HL, and 20 cm above HL. Finger blood flow on the left and right hand was measured every 30 s during each 25-min session comprised of five periods: (1) no force and no vibration (5 min), (2) 2-N force and no vibration (5 min), (3) 2-N force and vibration (5 min), (4) 2-N force and no vibration (5 min), and (5) no force and no vibration (5 min). RESULTS: Without vibration, FBF decreased with increasing elevation of the hand. During vibration of the right hand, FBF reduced on both hands. With elevation of the right hand, the percentage reduction in FBF due to vibration (relative to FBF on the same finger at the same elevation before exposure to vibration) was similar on the middle and little fingers of both hands. After cessation of vibration, there was delayed return of FBF with all three hand heights. CONCLUSIONS: Vibration of one hand reduces FBF on both exposed and unexposed hands, with the reduction dependent on the elevation of the hand. The mechanisms responsible for vibration-induced reductions in FBF seem to reduce blood flow as a percentage of the blood flow without vibration. Tasks requiring the elevation of the hands will be associated with lower FBF, and the FBF will be reduced further if there is exposure to hand-transmitted vibration.
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Dedos/irrigación sanguínea , Vibración/efectos adversos , Adulto , Mano/irrigación sanguínea , Síndrome por Vibración de la Mano y el Brazo/fisiopatología , Voluntarios Sanos , Humanos , Masculino , Flujo Sanguíneo Regional/fisiología , Adulto JovenRESUMEN
At work or in leisure activities, many people are exposed to vibration or mechanical shocks associated with risks of injury or disease. This paper identifies information that can be used to decide whether there may be a risk from exposure to hand-transmitted vibration or whole-body vibration and shock, and suggests actions that can control the risks. The complex and time-varying nature of human exposures to vibration and shock, the complexity of the different disorders and uncertainty as to the mechanisms of injury and the factors influencing injury have prevented the definition of dose-response relationships well proven by scientific study. It is necessary to wave a flag indicating when there is a need to control risks from exposure to vibration and shock while scientific enquiry provides understanding needed to weave a better flag. It is concluded that quantifying exposure severity is often neither necessary nor sufficient to either identify risks or implement measures that control the risks. PRACTITIONER SUMMARY: The identification of risks associated with exposure to vibration and mechanical shock cannot, and need not, rely solely on the quantification of exposure severity. Qualitative methods can provide a sufficient indication of the need for control measures, which should not be restricted to reducing standardised measures of exposure severity.
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Exposición a Riesgos Ambientales/efectos adversos , Fenómenos Mecánicos , Enfermedades Musculoesqueléticas/etiología , Administración de la Seguridad/métodos , Vibración/efectos adversos , Exposición a Riesgos Ambientales/análisis , Humanos , Medición de Riesgo/métodos , Factores de RiesgoRESUMEN
While walking on a treadmill, 20 subjects experienced lateral oscillations: frequencies from 0.5 to 2 Hz and velocities from 0.05 to 0.16 m s(- 1) rms. Postural stability was indicated by ratings of 'discomfort or difficulty in walking', the movement of the centre of pressure beneath the feet and lateral forces applied to a hand support. Hand support improved postural stability with all frequencies and all velocities of oscillatory motion: the lateral velocity of the centre of pressure reduced by 30-50% when using support throughout motion, by 20-30% when instructed to use the support only when required and by 15% during normal walking without oscillation. Improvements in stability, and the forces applied to the hand support, were independent of support height when used continuously throughout motion. When support was used only when required, subjects preferred to hold it 118-134 cm above the surface supporting the feet.
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Movimiento (Física) , Equilibrio Postural/fisiología , Caminata/fisiología , Aceleración , Adulto , Fenómenos Biomecánicos , Pie , Mano , Voluntarios Sanos , Humanos , Masculino , Movimiento , Presión , Equipo DeportivoRESUMEN
Few studies have investigated discomfort caused by multi-axis vibration and none has explored methods of predicting the discomfort of standing people from simultaneous fore-and-aft, lateral and vertical vibration of a floor. Using the method of magnitude estimation, 16 subjects estimated their discomfort caused by dual-axis and tri-axial motions (octave-bands centred on either 1 or 4 Hz with various magnitudes in the fore-and-aft, lateral and vertical directions) and the discomfort caused by single-axis motions. The method of predicting discomfort assumed in current standards (square-root of the sums of squares of the three components weighted according to their individual contributions to discomfort) provided reasonable predictions of the discomfort caused by multi-axis vibration. Improved predictions can be obtained for specific stimuli, but no single simple method will provide accurate predictions for all stimuli because the rate of growth of discomfort with increasing magnitude of vibration depends on the frequency and direction of vibration.
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Postura , Vibración , Aceleración , Adulto , Humanos , Masculino , Adulto JovenRESUMEN
The transmissibility of seat depends on the dynamics of both the seat and the human body, and shows how the amplification and attenuation of vibration varies with the frequency of vibration. A systematic methodology was developed for finite element (FE) modelling of the dynamic interaction between a seat and the human body and predicting the transmissibility of a seat. A seat model was developed to improve computational efficiency before models of the seat pan and backrest were calibrated separately using load-deflection and dynamic stiffness measurements, joined to form the complete seat model, and integrated with the model of a manikin for further calibration. The calibrated seat model was combined with a human body model to predict the transmissibility of the seat. By combining a calibrated seat model with a calibrated human body model, and defining appropriate contacts between the two models, the vibration transmissibility with a seat-occupant system can be predicted. PRACTITIONER SUMMARY: FE models are capable of reflecting complex dynamic characteristics of a seatbody system. A methodology for using FE methods to model a seatbody system to predict seat transmissibility has been demonstrated. The method can be developed to explore how seating dynamics interact with human biodynamics.