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IEEE/ACM Trans Comput Biol Bioinform ; 18(6): 2136-2143, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-31722482

RESUMEN

Maximum parsimony reconciliation is a fundamental technique for studying the evolutionary histories of pairs of entities such as genes and species, parasites and hosts, and species and their biogeographical habitats. In these contexts, reconciliation is generally performed using the duplication-transfer-loss (DTL) model in a maximum parsimony framework. While efficient maximum parsimony reconciliation algorithms are known for the DTL model, the number of such reconciliations can grow exponentially with the sizes of the two phylogenetic trees. Choosing a maximum parsimony reconciliation arbitrarily may lead to conclusions that are not supported, and may even be contradicted, by other equally optimal reconciliations. This paper addresses the fundamental problem of how well a single reconciliation can represent the entire space of optimal reconciliations.


Asunto(s)
Biología Computacional/métodos , Evolución Molecular , Duplicación de Gen/genética , Modelos Genéticos , Filogenia , Algoritmos
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