Skeletal Tuberculosis in Pediatric Population for 15 Years; Twenty Cases from Southern Turkey.

BACKGROUND: Skeletal tuberculosis is rarely seen among extrapulmonary tuberculosis, especially in childhood because the diagnosis may be delayed for years due to diagnostic difficulties. In this study, it was aimed to evaluate the clinical characteristics, methods used in diagnosis, treatment specifics, and prognosis of patients diagnosed with bone joint tuberculosis in childhood. MATERIALS AND METHODS: Twenty patients diagnosed with skeletal tuberculosis in our hospital between Jan 1, 2006, and Jan 1, 2021, were evaluated retrospectively. RESULTS: The age of the patients ranged from seven to 191 months. 70% of the patients presented with complaints of pain, 50% with swelling, and 20% with limping. The duration of the complaints was 3.82 ± 4 months on average. While 65% of the patients had isolated skeletal TB, 30% were accompanied with pulmonary tuberculosis. Tuberculin skin test (TST) was positive in 13 (65%) patients. Seven (35%) of the patients were diagnosed with proven TB. The most frequent involvement was seen in knee bones (25%), followed by vertebra (15%), foot (15%), and wrist (15%) bones. In the radiological findings, 65% of the patients had mass, 45% destruction, 35% enhancement/edema, 5% calcification/sclerosis, 5% cyst, and 35% soft tissue abscess. In the follow-up, 50% of the patients recovered without sequelae. CONCLUSION: Skeletal tuberculosis can easily be missed in childhood due to its slow insidious course, non-specific symptoms, and bone findings, resulting in delayed diagnosis and may lead to sequelae which affect lifelong quality of life. We should keep the possibility of skeletal tuberculosis in mind when we see the patients with limping or localized lesions accompanied with pain or swelling.

Sonographic measurements of Inferior Vena Cava, Aorta, anda IVC/aorta ratio in healthy children.

Background: Assessment of intravascular volume status is important in pediatric patients admitted to the emergency departments and pediatric intensive care units. Inferior vena cava (IVC) diameter and collapsibility index are used to evaluate the intravascular volume status in adults. The normal range of IVC diameter is available for adults and the normal range considered for adults is between 1.7 to 2.1 cm, but such normative data is limited for children of all ages. Aims: Our aim in this study was to obtain the IVC and the aorta diameter reference values and the mean vena cava collapsibility index in healthy and normovolemic children. Subjects and Methods: Vena cava inferior and aorta images in B mode were obtained. IVC diameter in the inspiratory and the largest IVC diameter in the expiratory were recorded, and the vena cava collapsibility index was calculated. Results: Ultrasonographic measurements were performed in total on 1938 children. A significant positive correlation was found between IVC and aorta diameters with age. The collapsibility index was found as 37.2% (SD 11.8) in the overall study population. In addition, the reference values for the IVC and aorta diameters obtained from the measurements were also acquired. Conclusions: We believe that our IVC and aorta diameter measurements obtained from a large number of participants may be used as reference values in emergency departments and intensive care units.

Evaluation of pediatric patients with COVID-19 in a Turkish university hospital.

Background: Although COVID-19 has a milder course in pediatric patients than in adults, it can have a severe and fatal course in children with an underlying disease (UD). Aims: In this study, we aimed to evaluate the demographic, clinical, laboratory, and radiological characteristics, treatment methods, and prognosis of pediatric patients diagnosed with COVID-19. Patients and Methods: The files of patients aged 0-18 years diagnosed with COVID-19 were retrospectively evaluated. Clinically and radiologically suspicious cases were accepted as confirmed cases if SARS-CoV-2 PCR positivity was found in nasopharyngeal swab samples. The severity of the disease was defined as asymptomatic, mild, moderate, and severe according to clinical, laboratory, and radiological features. Results: A total of 322 pediatric patients, 51.2% male and 48.8% female, were included in the study. The median age of the patients was 12.08 years (1 month-18 years). Of the 322 patients, 81 (25.1%) were asymptomatic. Disease severity was as follows: 218 were (67.7%) mild, 14 were (4.3%) moderate, and 9 (2.7%) were severe. 35.7% of the patients were hospitalized. Six percent were admitted to the intensive care unit, and three (0.93%) patients died. The mortality rate in patients with the UD was 3.3%. Conclusion: In our study, we determined that the disease had a more severe course in patients with initial procalcitonin, D-dimer, troponin increase, and thrombocytopenia. Although COVID-19 has a mild course in children, this is unfortunately not true for children with an UD.

Evaluation of Device-associated Nosocomial Infections in a Paediatric Intensive Care Unit.

OBJECTIVE: The aim of this study was to evaluate the rate of device-associated healthcare-associated infections (DA-HAI) in a paediatric intensive care unit (PICU). In addition, the identities of the responsible micro-organisms and of their antibiotic sensitivities were determined. SUBJECTS AND METHODS: Patients who had been treated and followed-up in a PICU for more than 48 hours between January 2008 and December 2013 were included in the study. Device-associated nosocomial infections were defined by the Centers for Disease Control (CDC) criteria. RESULTS: Nosocomial infections were detected in 244 of the 7376 patients over the six-year period. A diagnosis of DA-HAI was made in 75 (30.7%) of these infections. The rates of device utilization were 26% for mechanical ventilators, 6% for central venous catheters and 0.9% for urethral catheters. The rate of device-associated infections was 30.7%, and their frequency was 1.9/1000 patient-days. The device-associated nosocomial infection rates for mechanic ventilators, central and urethral catheters were 5.6, 1.62 and 3.77 per 1000 patient-days, respectively. Of these infections, Pseudomonas aeruginosa was the most frequent pathogen. Patients who developed hospital infections had longer durations of ICU hospitalizations and more often had to use mechanical ventilators and central and urinary catheters. CONCLUSIONS: The duration of hospitalization and the use of mechanical ventilators and central and urinary catheters were related to the increases in nosocomial infections. Therefore, target-oriented active surveillance should be regularly performed, and the superfluous employment of invasive devices should be avoided.