Super-Selective Intra-arterial Thrombolytic Therapy for Peripheral Facial Paralysis After Postauricular Hyaluronic Acid Injection for the Esthetic Correction of Lying Ears.

BACKGROUND: Hyaluronic acid (HA) injection in the auricular base is one of the most popular and non-surgical cosmetic procedures for correcting lying ears and optimizing the facial profile because of its minimal invasiveness, immediate effect and safety (Li et al. in Aesthet Surg J 44: 746-75, 2024). But we have recently discovered that this treatment may lead to a new and rare complication called peripheral facial paralysis that has never been reported before. Until now, the etiology, clinical traits, treatment strategies, outcomes and possible reversibility have not been characterized. METHODS: In the present study, we enrolled 4 patients with peripheral facial paralysis after subcutaneous postauricular HA filler injection. Preoperative digital subtraction angiography revealed a vascular embolism. Then, the patients underwent super-selective facial arterial thrombolytic therapy via hyaluronidase and papaverine injections. Simultaneously, general symptomatic treatment and nutritional therapy were performed. RESULTS: The patients were relieved of their clinical symptoms and the significant improvement was observed in terms of motor function in her left facial areas after treatment. The auricular skin necrosis of all patients was restored to near normal appearance. CONCLUSION: Our results indicate that super-selective facial arterial thrombolytic therapy is feasible for patients with peripheral facial paralysis induced by HA embolism. It was also beneficial in the recovery from skin necrosis. The therapy was shown to be worthy of clinical application. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Metal-Organic Framework-Derived Fe-Doped Co1.11 Te2 Embedded in Nitrogen-Doped Carbon Nanotube for Water Splitting.

A rational design is reported of Fe-doped cobalt telluride nanoparticles encapsulated in nitrogen-doped carbon nanotube frameworks (Fe-Co1.11 Te2 @NCNTF) by tellurization of Fe-etched ZIF-67 under a mixed H2 /Ar atmosphere. Fe-doping was able to effectively modulate the electronic structure of Co1.11 Te2 , increase the reaction activity, and further improve the electrochemical performance. The optimized electrocatalyst exhibited superior hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) performances in an alkaline electrolyte with low overpotentials of 107 and 297 mV with a current density of 10 mA cm-2 , in contrast to the undoped Co1.11 Te2 @NCNTF (165 and 360 mV, respectively). The overall water splitting performance only required a voltage of 1.61 V to drive a current density of 10 mA cm-2 . Density function theory (DFT) calculations indicated that the Fe-doping not only afforded abundant exposed active sites but also decreased the hydrogen binding free energy. This work provided a feasible way to study non-precious-metal catalysts for an efficient overall water splitting.