1.
Cancer Invest
; 30(7): 537-43, 2012 Aug.
Artículo
en Inglés
| MEDLINE
| ID: mdl-22737970
RESUMEN
Previously, we developed an orthotopic xenograft model of human glioblastoma multiforme (GBM) with high EGFR expression and invasiveness in Balb/c nu/nu nude mice. Now we also developed the same orthotopic xenograft model in transgenic nude mice with green fluorescent protein (GFP) expression. The present orthotopic xenografts labeled by phycoerythrin fluorescing red showed high EGFR expression profile, and invasive behavior under a bright green-red dual-color fluorescence background. A striking advantage in the present human GBM model is that the change of tumor growth can be observed visually instead of sacrificing animals in our further antitumor therapy studies.
Asunto(s)
Modelos Animales de Enfermedad , Genes erbB-1 , Glioblastoma/genética , Glioblastoma/patología , Ratones Transgénicos , Animales , Línea Celular Tumoral , Femenino , Expresión Génica , Glioblastoma/irrigación sanguínea , Proteínas Fluorescentes Verdes/metabolismo , Humanos , Ratones , Ratones Desnudos , Invasividad Neoplásica , Trasplante de Neoplasias , Trasplante Heterólogo
2.
Zhongguo Ying Yong Sheng Li Xue Za Zhi
; 35(4): 304-307, 2019 07 28.
Artículo
en Zh
| MEDLINE
| ID: mdl-31701711