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Purpose@#This study aims to elucidate the longitudinal alterations in frailty and health-related quality of life experienced by elderly patients undergoing surgical treatment for esophageal cancer. Additionally, it seeks to ascertain the impact of preoperative frailty on postoperative health-related quality of life over time. @*Methods@#131 patients were included in the prospective study. Patients' frailty and health-related quality-of-life were assessed utilizing the Tilburg and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 at preoperative, 1 week, 1 month, and 3 months, postoperatively. Statistical analyses were performed using generalized estimating equations, repeated-measures analysis of variance, and linear mixed models (LMMs). @*Results@#Out of 131 patients, 28.2% had frailty before surgery, and the prevalence of frailty consistently higher after surgery compared with baseline (67.9%, 51.9%, and 39.7%). There was no significant change in frailty scores in preoperative frail patients within 3 months following surgery (p = .496, p < .999, p < .999); whereas in preoperative non-frail patients, the frailty scores increased at 1 week (p < .001) and then decreased at 1 month (p = .014), followed by no change at 3 months. In addition, preoperative frail patients had significantly worse global quality-of-life (β = −4.24 (−8.31; −.18), p = .041), physical functioning (β = −9.87 (−14.59; −5.16), p < .001), role functioning (β = −10.04 (−15.76; −4.33), p = .001), and social functioning (β = −8.58 (−15.49; −1.68), p = .015), compared with non-frail patients. @*Conclusions@#A significant proportion of participants exhibited a high prevalence of preoperative frailty. These patients, who were preoperatively frail, exhibited a marked reduction in health-related quality-of-life, a more gradual recovery across various functional domains, and an increased symptom burden during the follow-up period. Therefore, it is crucial to meticulously identify and closely monitor patients with preoperative frailty for any changes in their postoperative physiology, role, and social functioning.
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Objective To explore the clinical significance of peripheral blood lymphocytesubsets detection in multiple myeloma (MM) patients with different immunophenotypes. Methods A total of 40 MM patients in People's Hospital of Xinjiang Uygur Autonomous Region from January 2016 to June 2016 were selected as the research objects, and 20 healthy examinations were treated as the control group. Marrow and blood samples were collected to detect the expressions of antigens and peripheral blood lymphocytesubsets by using flow cytometry. Besides, immunophenotype and the differences of lymphocytesubsets between the two groups were analyzed. Results The expression rates of CD138, CD38, CD56, CD19, CD20, CD45 were 100 %(40/40),100 %(40/40),75 %(30/40),0,20 %(8/40),0 in MM group and 100 %(20/20),100 %(20/20), 0,100 %(20/20), 100 %(20/20),75 %(15/20)in the control group.There were two kinds of immunophenotypes in MM group including CD138+CD38+CD56-CD19- (10 cases) and CD138+CD38+CD56+CD19- (30 cases). The absolute value of CD3+[(924±341)/ml vs. (1 474±270)/ml], CD4+[(410±163)/ml vs. (871±214)/ml], CD4+/CD8+[(1.0±0.3)/ml vs. (1.6±0.5)/ml], CD19+[(72±26)/ml vs. (277±89)/ml] was lower in MM group compared with the control group(P <0.05). There was no statistical difference in the absolute values of peripheral blood lymphocytesubsets for the patients with different immunophenotypes in MM patients (all P > 0.05). Conclusions Flow cytometry could help to type accurately the different immunophenotypes, distinguish the benign and malignant of plasmocytes and assist the diagnosis for the MM patients. Peripheral blood lymphocytesubsets analysis can be used to reflect the immunity of MM patients.