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1.
Arthroscopy ; 38(6): 1930-1932, 2022 06.
Artículo en Inglés | MEDLINE | ID: mdl-35660186

RESUMEN

Treatment of radial tears of the lateral meniscus is challenging. Previous studies after repairing radial tears showed low healing rates. Various suture techniques are now being developed, and biomechanical and clinical studies using these new techniques are underway. Amid development, the all-inside double vertical cross-suture technique seemed to be effective. However, limited evaluations after meniscal repair might not fully reveal whether the repaired meniscus can maintain its function. Because the best single method that can completely evaluate meniscal healing and its function after repair is still lacking, we should introduce various assessments and consider them in a comprehensive way.


Asunto(s)
Traumatismos de la Rodilla , Laceraciones , Lesiones de Menisco Tibial , Fenómenos Biomecánicos , Humanos , Traumatismos de la Rodilla/cirugía , Laceraciones/cirugía , Meniscos Tibiales/cirugía , Rotura/cirugía , Técnicas de Sutura , Suturas , Lesiones de Menisco Tibial/cirugía
2.
J Orthop Sci ; 27(4): 804-809, 2022 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-34030939

RESUMEN

BACKGROUND: A meniscal repair is often performed on radial/flap or longitudinal tears of the lateral meniscus (LM) combined with anterior cruciate ligament reconstruction (ACLR). However, it is unknown if meniscal extrusion changes over time after repair. This study evaluated whether meniscal extrusion of the LM is maintained after repair or progresses with time using magnetic resonance imaging (MRI). METHODS: Among 574 patients who underwent primary anatomic ACLR, 123 patients followed up for more than 2 years were retrospectively analyzed. Forty patients with concomitant radial/flap tears of the LM (group R), 43 with longitudinal LM tears (group L), and 40 with intact LM (group C, matched-control group) were included. Clinical findings (pain, range of motion, swelling, and anterior laxity), lateral joint space on radiograph, and meniscal extrusion on MRI were assessed. Lateral/posterior meniscal extrusions were examined preoperatively, within 3 weeks after surgery, and at the final follow-up, and the absolute values and relative values (the preoperative values as baseline) were assessed respectively. RESULTS: There were no significant differences in the clinical and roentgenographic findings among the groups. No difference was observed in the relative values within 3 weeks after surgery among three groups, although the absolute values were larger in the repaired groups than in group C. At the final follow-up, however, the lateral extrusion in group L had progressed significantly, compared with that in group C (P = 0.033), while no significant difference was detected in the lateral extrusion between groups R and C (P = 0.177). The posterior extrusion in groups R and L had progressed significantly compared with that in group C (P < 0.001). CONCLUSIONS: LM extrusion could not be improved even immediately after meniscal repair, and it progressed laterally and posteriorly for more than 2 years after surgery.


Asunto(s)
Lesiones del Ligamento Cruzado Anterior , Reconstrucción del Ligamento Cruzado Anterior , Lesiones del Ligamento Cruzado Anterior/complicaciones , Lesiones del Ligamento Cruzado Anterior/diagnóstico por imagen , Lesiones del Ligamento Cruzado Anterior/cirugía , Reconstrucción del Ligamento Cruzado Anterior/métodos , Estudios de Seguimiento , Humanos , Meniscos Tibiales/diagnóstico por imagen , Meniscos Tibiales/cirugía , Estudios Retrospectivos
3.
Knee Surg Sports Traumatol Arthrosc ; 29(11): 3782-3792, 2021 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-33452577

RESUMEN

PURPOSE: The purpose of this study was to evaluate the change in cross-sectional area (CSA) of bone-patellar tendon-bone (BTB) autografts up to 5 years after the anatomic rectangular tunnel (ART) anterior cruciate ligament reconstruction (ACLR). The changing pattern in CSA might be a potential indicator of the graft remodeling process. METHODS: Ninety-six (62 males, 34 females, mean age 27.0 years) patients were enrolled in this study with a total of 220 MRI scans after ART BTB ACLR to evaluate the CSA of the ACL autografts. The patients with first time unilateral ACLR that consented to undergo MRI evaluations at postoperative periods were included in this study. Intraoperatively, the CSA of the graft was measured directly using a custom-made area micrometer at the midpoint of the graft. Postoperatively, using an oblique axial slice MRI that was perpendicular to the long axis of the graft, the CSA of the graft was measured with digital radiology viewing program "SYNAPSE" at the midpoint of the graft. The postoperative MRI scans were classified into seven groups according to the period from ACLR to MRI evaluation: Group 0-2 months (m.), Group 3-6 m., Group 7-12 m., Group 1-2 years (y.), Group 2-3 y., Group 3-4 y., and Group 4 y.-. The percent increase of the CSA was calculated by dividing the postoperative CSA by the intraoperative CSA. RESULTS: The postoperative CSA was significantly larger than the intraoperative CSA in each group, with the exception of Group 0-2 m. The mean percent increase of the CSA in Group 0-2 m., 3-6 m., 7-12 m., 1-2 y., 2-3 y., 3-4 y., 4 y.- was 101.8 ± 18.2, 188.9 ± 27.4, 190.9 ± 43.7, 183.3 ± 28.9, 175.2 ± 27.9, 163.9 ± 19.8, 164.5 ± 25.4% respectively. The percent increase in Group 3-6 m., 7-12 m., 1-2 y., 2-3 y., 3-4 y., and 4 y.- was significantly greater than that in Group 0-2 m. CONCLUSIONS: The CSA of the BTB autografts after the ART BTB ACLR increases rapidly by 3-6 months after ACLR, reached a maximum value of 190% at around 1 year, decreases gradually after that, and reaches a plateau at around 3 years. The current study might help clinicians to estimate an individual BTB autograft's remodeling stages when considering returning patients to sports. LEVEL OF EVIDENCE: IV.


Asunto(s)
Lesiones del Ligamento Cruzado Anterior , Reconstrucción del Ligamento Cruzado Anterior , Ligamento Rotuliano , Adulto , Lesiones del Ligamento Cruzado Anterior/cirugía , Autoinjertos , Plastía con Hueso-Tendón Rotuliano-Hueso , Femenino , Humanos , Masculino , Rótula , Trasplante Autólogo
4.
Int J Mol Sci ; 22(1)2020 Dec 30.
Artículo en Inglés | MEDLINE | ID: mdl-33396695

RESUMEN

Synovial mesenchymal stem cell (SMSC) is the promising cell source of cartilage regeneration but has several issues to overcome such as limited cell proliferation and heterogeneity of cartilage regeneration ability. Previous reports demonstrated that basic fibroblast growth factor (bFGF) can promote proliferation and cartilage differentiation potential of MSCs in vitro, although no reports show its beneficial effect in vivo. The purpose of this study is to investigate the promoting effect of bFGF on cartilage regeneration using human SMSC in vivo. SMSCs were cultured with or without bFGF in a growth medium, and 2 × 105 cells were aggregated to form a synovial pellet. Synovial pellets were implanted into osteochondral defects induced in the femoral trochlea of severe combined immunodeficient mice, and histological evaluation was performed after eight weeks. The presence of implanted SMSCs was confirmed by the observation of human vimentin immunostaining-positive cells. Interestingly, broad lacunae structures and cartilage substrate stained by Safranin-O were observed only in the bFGF (+) group. The bFGF (+) group had significantly higher O'Driscoll scores in the cartilage repair than the bFGF (-) group. The addition of bFGF to SMSC growth culture may be a useful treatment option to promote cartilage regeneration in vivo.


Asunto(s)
Cartílago Articular/fisiología , Condrogénesis , Factor 2 de Crecimiento de Fibroblastos/metabolismo , Cápsula Articular/citología , Células Madre Mesenquimatosas/metabolismo , Regeneración , Animales , Biomarcadores , Diferenciación Celular , Proliferación Celular , Células Cultivadas , Modelos Animales de Enfermedad , Factor 2 de Crecimiento de Fibroblastos/farmacología , Expresión Génica , Humanos , Trasplante de Células Madre Mesenquimatosas , Células Madre Mesenquimatosas/citología , Células Madre Mesenquimatosas/efectos de los fármacos , Ratones , Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos/genética , Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos/metabolismo , Esferoides Celulares
5.
Circ J ; 82(2): 555-560, 2018 01 25.
Artículo en Inglés | MEDLINE | ID: mdl-29070745

RESUMEN

BACKGROUND: This study aimed to determine the incidence, characteristics and management of venous thromboembolism (VTE) in Japan during 2011.Methods and Results:A retrospective study assessed responses to a questionnaire regarding treating newly diagnosed VTE at all admitting hospitals throughout Japan during 2011. More individuals were diagnosed with VTE than ever before, with 16,096 cases of diagnosed pulmonary embolism (PE) and 24,538 cases of diagnosed deep vein thrombosis (DVT). Almost half (47.2%) of the PE patients had a relatively mild condition with no right ventricular overload. Similarly, almost half (43.8%) of the DVT patients had a relatively mild condition with isolated calf thrombus. Most of PE patients were treated by anticoagulation, and fewer were treated using thrombolytic agent or inferior vena cava (IVC) filter. CONCLUSIONS: The present study showed a remarkable increase in the incidence of VTE in Japan during 2011. Relatively mild conditions such as non-massive PE and isolated calf DVT were frequently diagnosed. Among PE patients, thrombolytic therapy or IVC filter implantation decreased compared with previous surveys. The appropriate management of isolated calf DVT requires further investigation.


Asunto(s)
Tromboembolia Venosa/epidemiología , Anticoagulantes/uso terapéutico , Manejo de la Enfermedad , Humanos , Incidencia , Japón/epidemiología , Pierna/patología , Embolia Pulmonar/terapia , Encuestas y Cuestionarios , Terapia Trombolítica , Filtros de Vena Cava , Tromboembolia Venosa/terapia
6.
Knee Surg Sports Traumatol Arthrosc ; 25(2): 390-396, 2017 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-28012004

RESUMEN

PURPOSE: The purpose of this study was to investigate the morphology of the discoid lateral meniscus sequentially following a partial meniscectomy with repair using magnetic resonance imaging (MRI). METHODS: Nine patients with a symptomatic discoid lateral meniscus with a peripheral tear were enrolled in this study, and a partial meniscectomy with repair was performed arthroscopically. An MRI examination was performed 2 weeks after surgery (before weight bearing was permitted) and again 6 months after surgery (when sporting activities could resume). The width, height and distance of the discoid lateral meniscus were measured. The distance was defined as the distance between the edges of the discoid lateral meniscus and the tibia. RESULTS: The width of the anterior, middle and posterior segments significantly decreased from 2 weeks to 6 months after surgery. The height of the middle and posterior segments significantly increased from 2 weeks to 6 months after surgery, whereas the height of the anterior segment did not significantly change. The distance of the anterior, middle and posterior segments significantly decreased from 2 weeks to 6 months after surgery. CONCLUSION: The discoid lateral meniscus exhibited deformation and extrusion from 2 weeks to 6 months after a partial meniscectomy with repair. Therefore, the function of load transmission might not be maintained appropriately after surgery. LEVEL OF EVIDENCE: IV.


Asunto(s)
Meniscos Tibiales/cirugía , Anomalías Musculoesqueléticas/cirugía , Complicaciones Posoperatorias/diagnóstico por imagen , Adolescente , Adulto , Artroscopía/métodos , Niño , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Meniscos Tibiales/anomalías , Meniscos Tibiales/diagnóstico por imagen , Anomalías Musculoesqueléticas/diagnóstico por imagen , Volver al Deporte , Tibia/diagnóstico por imagen , Resultado del Tratamiento , Soporte de Peso , Adulto Joven
7.
Knee Surg Sports Traumatol Arthrosc ; 25(4): 1219-1226, 2017 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-26585909

RESUMEN

PURPOSE: The purpose was to evaluate the cross-sectional area changes in hamstring tendon autografts up to 5 years after the anatomic triple-bundle anterior cruciate ligament (ACL) reconstruction. METHODS: A total of 178 MRI scans from 139 patients (35 males, 104 females, mean age 30.4 years) with the anatomic triple-bundle ACL reconstructions were obtained to evaluate the cross-sectional area of the ACL grafts. They were classified into seven groups according to the period from reconstruction to MRI evaluation: Group -2 months (m.), Group 3-6 m., Group 7-12 m, Group 1-2 years (y.), Group 2-3 y., Group 3-4 y., and Group 4 y.-. Intra-operatively, the cross-sectional area of the graft was measured directly using a custom-made area micrometre. Post-operatively, the cross-sectional area of the grafts' mid-substance was measured with oblique axial MRI slices perpendicular to the long axis of the grafts using a digital radiology viewing program. The percent increase in the cross-sectional area was calculated by dividing the post-operative cross-sectional area by the intra-operative cross-sectional area. RESULTS: The mean percent increase in the cross-sectional area in Groups -2 m., 3-6 m., 7-12 m., 1-2 y., 2-3 y., 3-4 y., and 4 y.- was 105.7 ± 14.0, 134.9 ± 20.0, 137.3 ± 27.8, 129.4 ± 22.2, 124.1 ± 20.4, 117.8 ± 16.9, and 117.1 ± 17.2 %, respectively. The percent increase in Groups 3-6 m., 7-12 m., and 1-2 y. was significantly greater than in Group -2 m., while that in Group 4 y.- was significantly less than in Group 7-12 m. CONCLUSIONS: The cross-sectional area of the hamstring tendon autografts after the anatomic triple-bundle ACL reconstruction increases over time up to 1 year post-operatively, decreases gradually thereafter, and reaches plateau at around 3 years. LEVEL OF EVIDENCE: Retrospective case series, Level IV.


Asunto(s)
Reconstrucción del Ligamento Cruzado Anterior/métodos , Autoinjertos/anatomía & histología , Tendones Isquiotibiales/trasplante , Adulto , Ligamento Cruzado Anterior/cirugía , Autoinjertos/diagnóstico por imagen , Femenino , Tendones Isquiotibiales/anatomía & histología , Tendones Isquiotibiales/diagnóstico por imagen , Humanos , Imagen por Resonancia Magnética , Masculino , Periodo Posoperatorio , Estudios Retrospectivos , Trasplante Autólogo
8.
J Orthop Traumatol ; 17(2): 181-5, 2016 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-26362782

RESUMEN

Drop foot is typically caused by neurologic disease such as lumbar disc herniation, but we report two rare cases of deep peroneal nerve palsy with isolated lateral compartment syndrome secondary to peroneus longus tears. Both patients developed mild pain in the lower legs while playing sport, and were aware of drop foot. As compartment pressures were elevated, fasciotomy was performed immediately, and the tendon of the peroneus longus was completely detached from its proximal origin. The patients were able to return their original sports after 3 months, and clinical examination revealed no hypesthesia or muscle weakness in the deep peroneal nerve area at the time of last follow-up. The common peroneal nerve pierced the deep fascia and lay over the fibular neck, which formed the floor of a short tunnel (the so-called fibular tunnel), then passed the lateral compartment just behind the peroneus longus. The characteristic anatomical situation between the fibular tunnel and peroneus longus might have caused deep peroneal nerve palsy in these two cases after hematoma adjacent to the fibular tunnel increased lateral compartment pressure.


Asunto(s)
Traumatismos en Atletas/complicaciones , Traumatismos en Atletas/cirugía , Síndromes Compartimentales/etiología , Síndromes Compartimentales/cirugía , Trastornos Neurológicos de la Marcha/etiología , Trastornos Neurológicos de la Marcha/cirugía , Nervio Peroneo/lesiones , Traumatismos de los Tendones/etiología , Traumatismos de los Tendones/cirugía , Adolescente , Béisbol/lesiones , Humanos , Imagen por Resonancia Magnética , Masculino , Parálisis/etiología , Parálisis/cirugía , Rotura , Fútbol/lesiones , Adulto Joven
10.
J Orthop Sci ; 19(1): 77-84, 2014 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-24077759

RESUMEN

BACKGROUND: The 2008 American Academy of Orthopedic Surgeons recommended that surgeons assess the relative risks of venous thromboembolism and bleeding in patients undergoing total knee arthroplasty (TKA). In this situation, a quantitative index is required for deciding whether to administer preventive anticoagulant therapy for deep venous thrombosis (DVT). In this study, we investigated the risk factors for DVT after TKA. METHODS: We included 102 patients (122 knees) who underwent primary TKA for osteoarthritis of the knee between October 2007 and March 2010. DVT was evaluated using lower limb venous ultrasonography. Cutoff values for individual risk factors were determined using a receiver-operating characteristic analysis, and the patients were grouped according to the cutoff values; the odds ratios (95% CI) were also investigated. The Wilcoxon signed-rank test and χ² test were also used. RESULTS: DVT was positive in 25 knees (20.5%). Three risk factors for DVT after TKA were identified: age 76 years or older, preoperative maximum soleus vein (MAX-SV) diameter of 6.0 mm or greater, and preoperative D-dimer value of 1.1 µg/dl or higher. The incidence of DVT was significantly higher in the group with two or more risk factors than in the group with one or no risk factors (p = 0.0001). CONCLUSIONS: Development of postoperative DVT correlated significantly with the presence of the following risk factors: age 76 years or older, preoperative MAX-SV diameter of 6.0 mm or greater, and a preoperative D-dimer value of 1.1 µg/dl or higher. Considering the risk-benefit ratio, avoiding preventive anticoagulant therapy following TKA can be an option for patients with osteoarthritis with one or no risk factors.


Asunto(s)
Anticoagulantes/administración & dosificación , Artroplastia de Reemplazo de Rodilla , Toma de Decisiones , Productos de Degradación de Fibrina-Fibrinógeno/metabolismo , Osteoartritis de la Rodilla/cirugía , Complicaciones Posoperatorias/prevención & control , Trombosis de la Vena/prevención & control , Anciano , Femenino , Estudios de Seguimiento , Humanos , Incidencia , Japón/epidemiología , Masculino , Osteoartritis de la Rodilla/sangre , Complicaciones Posoperatorias/sangre , Complicaciones Posoperatorias/epidemiología , Cuidados Preoperatorios , Estudios Retrospectivos , Medición de Riesgo , Factores de Riesgo , Trombosis de la Vena/sangre , Trombosis de la Vena/epidemiología
11.
Knee Surg Sports Traumatol Arthrosc ; 21(3): 736-9, 2013 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-22684428

RESUMEN

PURPOSE: To compare magnetic resonance (MR) signal intensity in the medial meniscus at the time of displacement and after its reduction in patients with a displaced bucket-handle tear of the meniscus associated with anterior cruciate ligament (ACL) injury. METHODS: Nine chronic ACL-deficient patients (3 male, 6 female, mean age 29 years) with locking due to a displaced fragment of the medial meniscus following a bucket-handle tear were involved in this study. In all patients, the following two-stage surgeries were planned as follows: first operation, arthroscopic reduction of the meniscus; second operation, meniscal repair and ACL reconstruction after immobilization for 1-2 weeks. Magnetic resonance imaging (MRI) evaluation using coronal T2*-weighted images was performed when the knee was locked and after the meniscus was reduced. Signal intensity before and after meniscal reduction was compared in the same patients. RESULTS: In 8 of the 9 patients, the displaced fragment exhibited high signal intensity in 1 patient and mildly high in 7 patients. After its reduction, the signal intensity changed to low in all 8 patients. CONCLUSIONS: A high-intensity signal in the displaced fragment of the medial meniscus may change to low after its reduction to its original position. Therefore, at the time of decision-making regarding meniscus repair for a displaced meniscus in a locked knee, surgeons should give priority to arthroscopic findings rather than to signal intensity on MRI. LEVEL OF EVIDENCE: Diagnostic study, Level III.


Asunto(s)
Lesiones del Ligamento Cruzado Anterior , Traumatismos de la Rodilla/diagnóstico , Imagen por Resonancia Magnética , Lesiones de Menisco Tibial , Adulto , Artroscopía , Femenino , Humanos , Traumatismos de la Rodilla/cirugía , Masculino , Meniscos Tibiales/cirugía , Procedimientos de Cirugía Plástica
13.
Int Orthop ; 37(3): 441-5, 2013 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-23371424

RESUMEN

PURPOSE: Tranexamic acid (TXA) reduces blood loss in patients undergoing total knee arthroplasty (TKA). However, few studies have reported the optimum timing and dosage for administration of TXA. The purpose of this study was to evaluate the effect of repeat-dose TXA on blood loss during TKA and the necessity of autologous blood donation or postoperative autotransfusion. METHODS: We enrolled 78 patients with primary osteoarthritis undergoing cemented TKAs. Consecutive patients were divided into three groups, as follows: control group (n = 31), single-TXA group (n = 21) in whom TXA (1,000 mg) was intravenously administered 10 min before deflation of the tourniquet, and twice-TXA group (n = 26) in whom TXA (1,000 mg) was intravenously administered 10 min before deflation of the tourniquet and 3 h after the operation. We measured the volume of drained blood after the operation. Haemoglobin (Hb) levels were measured at days 1, 4 and 7 postoperation. Venous thromboembolic events (VTE) were screened using compression ultrasonography at enrollment and 1 and 7 days after operation. RESULTS: The mean volume of drained blood after the operation was lower in the twice-TXA group than in the single-TXA (p < 0.001) and control (p < 0.0001) groups. No significant differences were observed in the incidence of VTE between these groups. CONCLUSION: Administration of TXA twice reduced postoperative blood loss after TKA, and TXA was not associated with the risk of deep-vein thrombosis (DVT) or pulmonary embolism (PE). Further, administration of TXA twice may eliminate the need for blood transfusion during TKA.


Asunto(s)
Antifibrinolíticos/administración & dosificación , Artroplastia de Reemplazo de Rodilla , Pérdida de Sangre Quirúrgica/prevención & control , Osteoartritis de la Rodilla/cirugía , Ácido Tranexámico/administración & dosificación , Anciano , Transfusión Sanguínea , Femenino , Humanos , Masculino
14.
Mod Rheumatol ; 23(3): 450-5, 2013 May.
Artículo en Inglés | MEDLINE | ID: mdl-22692649

RESUMEN

OBJECTIVES: We aimed to evaluate the clinical efficacy of monotherapy with alendronate and combined therapy with alendronate and menatetrenone (vitamin K2 [VitK2]) in postmenopausal rheumatoid arthritis (RA) patients with osteoporosis or osteopenia. METHODS: Sixty-two postmenopausal RA patients with untreated osteoporosis or osteopenia (lumbar spine bone density ≤80 % of young adult mean [YAM]) were enrolled: 39 had abnormal serum undercarboxylated osteocalcin (ucOC) levels (>4.5 ng/mL) and received combined therapy with alendronate (35 mg/week) and VitK2 (45 mg/day) (ALN + K group); 23 had normal ucOC levels (≤4.5 ng/mL) and received alendronate monotherapy (35 mg/week) (ALN group). The clinical results for the 57 patients in both groups were evaluated after 1-year treatment. RESULTS: The mean baseline/follow-up (FU) lumbar spine bone density (%YAM) values were 73.0/76.8 % (P < 0.01) in the ALN + K group and 77.0/80.3 % (P < 0.01) in the ALN group; a significant increase was shown in both groups. Mean proximal femoral bone density values at baseline/FU were 71.4/73.8 (P < 0.01) in the ALN + K group and 71.4/71.6 % (not significant; NS) in the ALN group; a significant increase was shown in the ALN + K group only. Serum ucOC levels were normalized in the ALN + K group at FU. At FU, bone metabolism markers [bone-specific alkaline phosphatase (BAP) and N-terminal cross-linked telopeptides of type I collagen] were decreased in both groups. One patient in the ALN + K group and three in the ALN group suffered new fractures. CONCLUSIONS: Combined therapy with alendronate and VitK2 decreases bone metabolism marker levels and serum ucOC levels, and increases lumbar spine and femoral neck bone density in postmenopausal RA patients with abnormal ucOC levels and osteoporosis or osteopenia.


Asunto(s)
Alendronato/uso terapéutico , Artritis Reumatoide/tratamiento farmacológico , Conservadores de la Densidad Ósea/uso terapéutico , Densidad Ósea/efectos de los fármacos , Osteoporosis Posmenopáusica/tratamiento farmacológico , Vitamina K 2/análogos & derivados , Anciano , Artritis Reumatoide/complicaciones , Conservadores de la Densidad Ósea/administración & dosificación , Quimioterapia Combinada , Femenino , Humanos , Persona de Mediana Edad , Osteoporosis Posmenopáusica/complicaciones , Posmenopausia , Estudios Prospectivos , Resultado del Tratamiento , Vitamina K 2/uso terapéutico
15.
Mod Rheumatol ; 23(3): 529-37, 2013 May.
Artículo en Inglés | MEDLINE | ID: mdl-22752535

RESUMEN

OBJECTIVES: Adalimumab, a fully human anti-tumor necrosis factor monoclonal antibody, was retrospectively evaluated for its effect on musculoskeletal manifestations and health-related quality of life in patients with psoriatic arthritis (PsA) during daily clinical practice. METHODS: Patients who initiated adalimumab therapy after March 2010 were followed for at least 24 weeks with the clinical outcome measures. Eleven patients, all men with a mean age of 45.4 years, had mean psoriasis durations of 16.2 and 8.4 years at baseline. RESULTS: After 24 weeks, 72.7, 63.6, and 45.5 % of the patients met the ACR 20, 50, and 70 response criteria, respectively, while 81.8 % achieved the PsA response criteria. Disease Activity Score using the 28-joint count and CRP declined from 3.2 ± 1.2 at baseline to 1.3 ± 0.4 at week 24 (P < 0.01). The Bath Ankylosing Spondylitis Disease Activity Index and Bath Ankylosing Spondylitis Functional Index scores also decreased significantly (both P values were <0.01). After 24 weeks, three out of eight dimensions of the Medical Outcomes Study 36-Item Short Form Health Survey and Physical Component Summary were significantly improved (all P values were <0.05). CONCLUSIONS: Adalimumab exerted its effect as early as week 4, and it was sustained until the end of the 24-week observation period in the PsA patients.


Asunto(s)
Anticuerpos Monoclonales Humanizados/uso terapéutico , Antirreumáticos/uso terapéutico , Artritis Psoriásica/tratamiento farmacológico , Espondilitis Anquilosante/tratamiento farmacológico , Adalimumab , Adulto , Artritis Psoriásica/psicología , Evaluación de la Discapacidad , Estado de Salud , Humanos , Masculino , Persona de Mediana Edad , Calidad de Vida , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Resultado del Tratamiento
16.
J Spinal Disord Tech ; 25(7): E199-203, 2012 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-22262025

RESUMEN

STUDY DESIGN: : A retrospective investigation. OBJECTIVE: : To clarify at which age and at what point in the postoperative period neurological deterioration occurs in patients with cervical spondylotic myelopathy. SUMMARY OF BACKGROUND DATA: : Inferior surgical outcomes tend to be seen with increasing age, however, the age threshold and the postoperative period associated with deterioration have not been established. METHODS: : Of 273 patients who underwent laminoplasty, 75 were enrolled in our study who met the criteria of having cervical spondylotic myelopathy, being monitored for a minimum of 2 years after surgery, and experiencing no morbidities within 2 years after surgery. Participants were classified into 4 age groups: group A, 54 years or below (n=12); group B, 55-64 years (n=22); group C, 65-74 years (n=24); and group D, 75 years or above (n=17). Preoperative physical status scores, using the American Society of Anesthesiologists (ASA) classification system, and neurological recovery, indicated by Japanese Orthopaedic Association (JOA) scores, were compared and surgical complications were reviewed. RESULTS: : The ASA physical status score was significantly lower in group A (1.4±0.5) than in group C (2.0±0.5) or group D (2.2±0.4) (P<0.0083). No difference was seen between the preoperative and 1-year postoperative JOA scores between the groups. However, the JOA score at ≥2 years after surgery was significantly lower in group D (12.9±2.0) than in group A (15.2±1.4; P<0.0083). Major complications of cardiopulmonary disorders were documented only in patients in groups C and D with A higher ASA scores. CONCLUSIONS: : Inferior surgical outcomes were seen in patients 75 years of age or above at 2 years after surgery compared with patients of 54 years or below of age. These clinical features could be reasonably explained by the patients' preexisting physical status related to age.


Asunto(s)
Vértebras Cervicales/cirugía , Descompresión Quirúrgica/efectos adversos , Espondilosis/cirugía , Factores de Edad , Anciano , Anciano de 80 o más Años , Envejecimiento , Femenino , Humanos , Masculino , Persona de Mediana Edad , Periodo Posoperatorio , Estudios Retrospectivos , Resultado del Tratamiento
17.
Mod Rheumatol ; 22(3): 353-62, 2012 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-21904784

RESUMEN

We prospectively evaluated the effects of celecoxib (CEL) on the gastrointestinal (GI) tract of rheumatoid arthritis (RA) patients with endoscopically identified GI mucosal injury after therapeutic switching from the long-term use of traditional nonsteroidal anti-inflammatory drugs (NSAIDs). Upper GI endoscopy was performed on RA patients who had been treated with NSAIDs for ≥3 months. GI mucosal injury was evaluated according to the modified LANZA score. Patients with mucosal injury without ulcers were switched from NSAIDs to CEL, while those with ulcers were switched to CEL with famotidine after ulcer healing. At week 16 of treatment, GI mucosal injury was endoscopically revaluated. An efficacy analysis was performed before therapeutic switching and at 8 and 16 weeks post-switching. Endoscopic analysis revealed GI mucosal injury, including six ulcers, in 45 of the 82 patients (54.9%). Sixteen weeks after switching to CEL, LANZA scores were significantly improved [2.1 ± 0.8 (pre-switching) vs. 1.6 ± 1.3, P = 0.0073] in patients with LANZA scores of 1, 2, or 3 (n = 35). The Disease Activity Score using 28 joint counts (DAS28) [erythrocyte sedimentation rate item score (ESR4) (P = 0.0257) and C-reactive protein item score (CRP4) (P = 0.0031)] was also significantly improved by week 16. Based on these results, we conclude that preexisting NSAID-induced upper GI injury is improved following therapeutic switching to CEL without any reduction in analgesic efficacy.


Asunto(s)
Artritis Reumatoide/tratamiento farmacológico , Inhibidores de la Ciclooxigenasa 2/uso terapéutico , Tracto Gastrointestinal/efectos de los fármacos , Pirazoles/uso terapéutico , Úlcera Gástrica/tratamiento farmacológico , Sulfonamidas/uso terapéutico , Anciano , Antiinflamatorios no Esteroideos/efectos adversos , Antiinflamatorios no Esteroideos/uso terapéutico , Celecoxib , Esquema de Medicación , Sustitución de Medicamentos , Endoscopía Gastrointestinal , Mucosa Gástrica/efectos de los fármacos , Humanos , Persona de Mediana Edad , Estudios Prospectivos , Pirazoles/farmacología , Úlcera Gástrica/inducido químicamente , Sulfonamidas/farmacología
18.
JBJS Case Connect ; 12(3)2022 07 01.
Artículo en Inglés | MEDLINE | ID: mdl-36040073

RESUMEN

CASE: A 17-year-old male patient suffered a radial lateral meniscus tear and underwent an arthroscopic all-inside suture repair. After 7 months, the patient experienced catching. Magnetic resonance imaging and computed tomography revealed an intra-articular loose body without calcification, which was removed surgically. The excised specimen was histopathologically confirmed to be a necrotic meniscus fragment with a suture knot. In addition, cartilage damage because of suspected impingement by a residual suture knot was observed. After removing the loose body and knot, the patient's symptoms were relieved, and he returned to sports. CONCLUSION: Suture knot-related complications should be considered while performing meniscal repairs.


Asunto(s)
Traumatismos de la Rodilla , Menisco , Lesiones de Menisco Tibial , Adolescente , Artroscopía/efectos adversos , Artroscopía/métodos , Humanos , Traumatismos de la Rodilla/diagnóstico por imagen , Traumatismos de la Rodilla/cirugía , Masculino , Menisco/cirugía , Técnicas de Sutura , Suturas/efectos adversos , Lesiones de Menisco Tibial/diagnóstico por imagen , Lesiones de Menisco Tibial/etiología , Lesiones de Menisco Tibial/cirugía
19.
Knee Surg Sports Traumatol Arthrosc ; 19(5): 826-8, 2011 May.
Artículo en Inglés | MEDLINE | ID: mdl-21127836

RESUMEN

We report a rare case of longitudinal tear of the anterior segment of the medial meniscus in association with the anteromedial meniscofemoral ligament (AMMFL) in an anterior cruciate ligament-injured knee. The tear was repaired, and the anterior horn was transferred to the tibia using the pull-out technique after excising the AMMFL. Repeat arthroscopy performed 7 months postoperatively revealed that the medial meniscus had completely healed and the anterior horn was firmly fixed to the tibia. Two years after the surgery, the patient could play basketball without any symptom. A posteroanterior flexion weight-bearing radiograph did not show any narrowing of the medial joint space. Considering the excellent healing observed in this case, preservation of the meniscus should be considered despite an association between a torn meniscus and an anomalous insertion.


Asunto(s)
Ligamento Cruzado Anterior/cirugía , Artroscopía/métodos , Baloncesto/lesiones , Traumatismos de la Rodilla/cirugía , Ligamentos Articulares/cirugía , Meniscos Tibiales/cirugía , Adolescente , Lesiones del Ligamento Cruzado Anterior , Femenino , Humanos , Ligamentos Articulares/lesiones , Lesiones de Menisco Tibial , Soporte de Peso
20.
JBJS Case Connect ; 11(3)2021 07 15.
Artículo en Inglés | MEDLINE | ID: mdl-34264869

RESUMEN

CASE: We describe a rare case of posterior root avulsion fracture of the medial meniscus in an 11-year-old boy. Previous reports have demonstrated delayed diagnosis, but in this case, multiplanar computed tomography (CT) combined with magnetic resonance imaging (MRI) enabled early diagnosis and treatment. Gradual ossification was observed after arthroscopic suture fixation, and meniscal extrusion did not progress. He returned to sports without any symptoms and showed no degenerative changes at 2.5 years postoperatively. CONCLUSION: This is the first case report of early diagnosis and time-course analysis of a rare avulsion fracture, emphasizing the usefulness of CT combined with MRI.


Asunto(s)
Fracturas por Avulsión , Lesiones de Menisco Tibial , Niño , Fracturas por Avulsión/diagnóstico por imagen , Fracturas por Avulsión/patología , Fracturas por Avulsión/cirugía , Humanos , Imagen por Resonancia Magnética/métodos , Masculino , Meniscos Tibiales/diagnóstico por imagen , Meniscos Tibiales/patología , Meniscos Tibiales/cirugía , Lesiones de Menisco Tibial/diagnóstico por imagen , Lesiones de Menisco Tibial/patología , Lesiones de Menisco Tibial/cirugía
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