[A dosage regimen of M-receptor blocker after TURP for severe BPH with predominant urine storage symptoms].

OBJECTIVE: To study the dosage regimen of oral M-receptor blocker following transurethral resection of the prostate (TURP) for severe benign prostate hyperplasia (BPH) with predominant urine storage period symptoms (USPSs) and its clinical effect. METHODS: Severe BPH patients with predominant USPSs received oral tolterodine (2 mg q12d or 4 mg qd) 6 hours after TURP for 4 weeks. The medication continued for another 2 weeks in case of recurrence of USPSs or until the 12th week in case of repeated recurrence. Before and at 1, 4, 8 and 12 weeks after TURP, we analyzed the International Prostate Symptoms Score (IPSS), quality of life (QoL) score, maximum urinary flow rate (Qmax), and postvoid residual volume (PVR) of the patients. RESULTS: Complete clinical data were collected from 106 cases, of which 33 achieved successful drug withdrawal with no aggravation of USPSs at 4 weeks after TURP, 51 at 6－8 weeks, 13 at 10－12 weeks, and 9 needed medication after 12 weeks. Before and at 1, 4, 8 and 12 weeks after TURP, the total IPSSs were 25.33 ± 3.45, 19.33 ± 3.62, 11.56 ± 2.45, 8.38 ± 2.0 and 7.74 ± 1.87, those in the urine storage period were 11.97 ± 1.53, 10.76 ± 1.82, 6.16 ± 1.22, 4.08 ± 1.19 and 3.91 ± 1.15, those at urine voiding were 9.80 ± 1.60, 5.59 ± 1.45, 3.40 ± 0.92, 2.85 ± 0.71, and 2.61 ± 0.67, and the QoL scores were 4.70 ± 0.78, 3.92 ± 0.75, 2.55 ± 0.74, 1.83 ± 0.72 and 1.66 ± 0.75, respectively, with statistically significant differences between the baseline and the scores at 1 and 4 weeks (P <0.01) but not at 8 or 12 weeks (P >0.05). Qmax and PVR were improved progressively and significantly at 1 and 4 weeks (P <0.01) but not at 8 or 12 weeks (P >0.05). CONCLUSIONS: Four to eight weeks of oral administration of M-receptor blocker may be an effective dosage regimen for severe BPH with predominant USPSs after TURP.

[Advances in diagnosis and treatment of renal cell carcinoma with inferior vena cava tumor thrombus].

The diagnosis,surgical treatment,and comprehensive treatment of renal cell carcinoma with inferior vena cava tumor thrombus have advanced rapidly in recent years. Both the survival and quality of life of the patients have remarkably improved. Further advance in basic research may provide new direction of management of renal cell carcinoma.

Expression of ICAM-1, HLA-DR, and CD80 on peripheral circulating CD1 alpha DCs induced in vivo by IFN-alpha in patients with chronic hepatitis B.

AIM: To explore the effects of interferon-alpha (IFN-alpha) application on peripheral circulating CD1alpha dendritic cells (DCs)in patients with chronic hepatitis B, and the expression of HLA-DR, CD80, and ICAM-1 on CD1alpha DCs in order to explore the mechanism of immune modulation of IFN-alpha. METHODS: By flow cytometry technique, changes of CD1alpha DCs were monitored in 22 patients with chronic hepatitis B treated with IFN-alpha and in 16 such patients not treated with IFN-alpha within three months. Meanwhile, the expression of HLA-DR, CD80, and ICAM-1 on CD1alpha DCs was detected. RESULTS: In the group of IFN-alpha treatment, the percentage of CD1alpha DCs in peripheral blood mononuclear cells was increased after three months of therapy. In patients who became negative for HBV-DNA after IFN-alpha treatment, the increase of DCs was more prominent, while in control, these changes were not observed. Increased expression of HLA-DR, CD80,and ICAM-1 on CD1alpha DCs was also observed. CONCLUSION: CD1alpha DCs can be induced by IFN-alpha in vivo, and the immune related molecules such as HLA-DR, CD80,and ICAM-1 are up-regulated to some degree. This might be an important immune related mechanism of IFN-alpha treatment for chronic hepatitis B.

[Delivery and release of sediment PAHs during resuspension].

The resuspension of sediment after being disturbed is simulated by particle entrainment simulator (PES). The conclusions came out as follows. Sediment nature like granulometric composition and sediment PAHs richness markedly affected the release of PAHs. During the resuspension experiment, the total suspended solids (TSS) content of the overlying water showed significant correlation with particulate PAHs. The influence of the shear stress on the release of PAHs was reflected on two aspects. On one hand, its increase was accompanied with the increase of particulate PAHs. On the other hand, the PAHs enrichment effect of TSS decreased with the increase in the shear stress, since the stronger shear stress could draw more coarse particles with fewer PAHs into overlying water. The total PAHs in the overlying water continued to raise before stabilization at 120 min or 240 min. The particulate PAHs and dissolved PAHs answered each other very well. The release behavior among PAHs of different weight varied significantly. Due to the hydrophobic property of heavy weight PAHs, PAHs detected in overlying water were mostly 3-ring or 4-ring.

The effect of continuous Zn (II) exposure on the organic degradation capability and soluble microbial products (SMP) of activated sludge.

This study describes the change of organic degradation capability and soluble microbial products (SMP) generated in activated sludge under continuous exposure to Zn (II) in a sequencing batch reactor (SBR). In 338 days of operation, the added Zn (II) concentrations were gradually increased from 50 to 100, 200, 400 to 600 and 800 mg/L. Results showed that after adaptation, the activated sludge could endure 400mg/L Zn (II) without showing evident reduction in organic degradation ability (92±1% of chemical oxygen demand (COD) removal in stable state). However, when 600 and 800 mg/L Zn (II) were applied, the effluent water quality significantly deteriorated. Meanwhile, under increasing Zn (II) concentrations, the SMP content in the activated sludge, together with its main biochemical constituents, first increased slightly below 400mg/L of Zn (II), then rose sharply under 600 and 800 mg/L Zn (II). Furthermore, a close correlation was found between SMP content and effluent soluble COD in both the Experimental Reactor and Control Reactor. In addition, the Zn (II) concentrations in the effluent and SMP extraction liquid were further analyzed and discussed to reveal the role that SMP constituents played in defense and resistance to the toxicity of Zn (II).

Phosphorus loads from different urban storm runoff sources in southern China: a case study in Wenzhou City.

Storm runoff from six types of underlying surface area during five rainfall events in two urban study areas of Wenzhou City, China was investigated to measure phosphorus (P) concentrations and discharge rates. The average event mean concentrations (EMCs) of total phosphorus (TP), total dissolved phosphorus (TDP), and particulate phosphorus (PP) ranged from 0.02 to 2.5 mg · L(-1), 0.01 to 0.48 mg · L(-1), and 0.02 to 2.43 mg · L(-1), respectively. PP was generally the dominant component of TP in storm runoff, while the major form of P varied over time, especially in roof runoff, where TDP made up the largest portion in the latter stages of runoff events. Both TP and PP concentrations were positively correlated with pH, total suspended solids (TSS), and biochemical oxygen demand (BOD)/chemical oxygen demand (COD) concentrations (p<0.01), while TDP was positively correlated with BOD/COD only (p<0.01). In addition, the EMCs of TP and PP were negatively correlated with maximum rainfall intensity (p<0.05), while the EMCs of TDP positively correlated with the antecedent dry weather period (p<0.05). The annual TP emission fluxes from the two study areas were 367.33 and 237.85 kg, respectively. Underlying surface type determined the TP and PP loadings in storm runoff, but regional environmental conditions affected the export of TDP more significantly. Our results indicate that the removal of particles from storm runoff could be an effective measure to attenuate P loadings to receiving water bodies.

[Distribution and ecological risk assessment of polycyclic aromatic hydrocarbons in agricultural soil of the Chongming Island in Shanghai].

The concentration and ecological risk of Polycyclic aromatic hydrocarbons (PAHs) were investigated in thirty-three surface soil samples collected from cultivated land in Chongming Island in July 2008. Those samples were extracted using an accelerated solvent extractor (ASE) and determined by GC-MS. Results showed that the concentrations of PAHs ranged between 24.92-1014.61 ng x g(-1) (dry weight), with a mean value of 192.83 ng x g(-1). The sixteen priority PAHs with exception of Indeno(1, 2, 3-cd) pyrene (IcdP) and Dibenzo(a, h)anthracene (DahA) were all detected in all the samples. The dominant compounds were 2-3 ring and 4 ring PAHs, which accounted for 42.6% and 42.2%, respectively, while the 5-6 ring PAHs accounted for 15.7%. PAHs in soil were mainly derived from the fossil oil and the combustion of wood and coal, as determined by the concentration ratio method. The non-industrial combustion and automobile exhaust emissions in Chongming Island may be two of the important sources of PAHs in farmland soil. The analysis of ecological risk showed that the agricultural soil of Chongming Island had low ecological risk.

Safety and effectiveness of percutaneous embolization for late failed renal allograft in patients with graft intolerance syndrome / 中国医学科学院学报

<p><b>OBJECTIVE</b>To investigate the clinical safety and effectiveness of percutaneous embolization in treating the late failed renal allograft in patients with graft intolerance syndrome (GIS).</p><p><b>METHODS</b>Transcatheter embolization of renal graft artery was performed in 18 patients with late graft dysfunction and GIS. The subsequent complications, postoperative symptom remission rate, and prognosis were assessed.</p><p><b>RESULTS</b>GIS was relieved in 15 patients (83.3%), of which 6 patients (33.3%) had severer fever and pain in the area of renal graft after embolization, which lasted for a mean of 3.5 days (range: 2-5 days). GIS persisted for more than 2 weeks in 3 patients (16.7%), who ultimately underwent surgical removal of grafts. No severe embolism-associated complications were noted.</p><p><b>CONCLUSION</b>Percutaneous embolization can effectively avoid surgical graft removal in patients with late renal allograft failure, and therefore can be used as a safe and effective treatment for the late failed renal allograft combined with GIS.</p>